Dolutegravir-based and low-dose efavirenz-based regimen for the initial treatment of HIV-1 infection (NAMSAL): week 96 results from a two-group, multicentre, randomised, open label, phase 3 non-inferiority trial in Cameroon

Autor: Alexandra Calmy, Tamara Tovar Sanchez, Charles Kouanfack, Mireille Mpoudi-Etame, Sandrine Leroy, Ségolène Perrineau, Martial Lantche Wandji, Darius Tetsa Tata, Pierette Omgba Bassega, Thérèse Abong Bwenda, Marie Varloteaux, Marcel Tongo, Eitel Mpoudi-Ngolé, Alice Montoyo, Noémie Mercier, Vincent LeMoing, Martine Peeters, Jacques Reynes, Eric Delaporte, A Calmy, T Tovar Sanchez, C Kouanfack, M Mpoudi-Etame, S Leroy, S Perrineau, M Lantche-Wandji, D Tetsa-Tata, P Omgba-Bassega, T Abong-Bwenda, M Varloteaux, M Tongo, E Mpoudi-Ngolé, A Montoyo, N Mercier, V LeMoing, M Peeters, J Reynes, E Delaporte, A Ayouba, A Agholeng, C Butel, A Cournil, S Eymard-Duvernay, B Granouillac, S Izard, A Lacroix, L Serrano, N Vidal, PJ Fouda, R Mougnoutou, J Olinga, V Omgba, SC Tchokonte-Ngandé, B Ymele, CD Epoupa-Mpacko, M Fotso, R Moukoko, T Nké, A Akamba, S Lekelem, SB Tongo-Fotack, S Ngono, M Tanga, E Ebong, G Edoul-Mbesse, L Ciaffi, S Koulla-Shiro, G Manirakiza, ED Mimbé, S Boyer, M Bousmah, G Maradan, ML Nishimwe, B Spire, MP Lê, G Peytavin, A Diallo, I Fournier, C Rekacewicz, C Perez Casas

Publikováno v: The Lancet HIV
The Lancet HIV, 2020, 7 (10), pp.e677-e687. ⟨10.1016/S2352-3018(20)30238-1⟩

International audience; Background: Updated WHO guidelines recommend a dolutegravir-based regimen as the preferred first-line treatment for HIV infection and low-dose efavirenz (400 mg) as an alternative. We aimed to report the non-inferior efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04f3e8044bec57d70cb397c548401b0
https://hal.umontpellier.fr/hal-03337700

CD41 T cell recovery during suppression of HIV replication: an international comparison of the immunological efficacy of antiretroviral therapy in North America, Asia and Africa

Autor: Geng, Elvin H, Neilands, Torsten B, Thièbaut, Rodolphe, Bwana, Mwebesa Bosco, Nash, Denis, Moore, Richard D, Wood, Robin, Zannou, Djimon Marcel, Althoff, Keri N, Lim, Poh Lian, Nachega, Jean B, Easterbrook, Philippa J, Kambugu, Andrew, Little, Francesca, Nakigozi, Gertrude, Nakanjako, Damalie, Kiggundu, Valerian, Ki Li, Patrick Chung, Bangsberg, David R, Fox, Matthew P, Prozesky, HansW, Hunt, Peter W, Davies, Mary-Ann, Reynolds, Steven J, Egger, Matthias, Yiannoutsos, Constantin T, Vittinghoff, Eric V, Deeks, Steven G, Martin, Jeffrey N

Publikováno v: International Journal of Epidemiology
International Journal of Epidemiology, Oxford University Press (OUP), 2015, 44 (1), pp.251-63
International Journal of Epidemiology, 2015, 44 (1), pp.251-63
Geng, Elvin H; Neilands, Torsten B; Thièbaut, Rodolphe; Bwana, Mwebesa Bosco; Nash, Denis; Moore, Richard D; Wood, Robin; Zannou, Djimon Marcel; Althoff, Keri N; Lim, Poh Lian; Nachega, Jean B; Easterbrook, Philippa J; Kambugu, Andrew; Little, Francesca; Nakigozi, Gertrude; Nakanjako, Damalie; Kiggundu, Valerian; Ki Li, Patrick Chung; Bangsberg, David R; Fox, Matthew P; ... (2015). CD41 T cell recovery during suppression of HIV replication: an international comparison of the immunological efficacy of antiretroviral therapy in North America, Asia and Africa. International journal of epidemiology, 44(1), pp. 251-263. Oxford University Press 10.1093/ije/dyu271

BACKGROUND Even among HIV-infected patients who fully suppress plasma HIV RNA replication on antiretroviral therapy, genetic (e.g. CCL3L1 copy number), viral (e.g. tropism) and environmental (e.g. chronic exposure to microbial antigens) factors influ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3545fccd41160f696919d84a0ecd9eac
https://hal.inria.fr/hal-01288872

The effect of efavirenz versus nevirapine-containing regimens on immunologic, virologic and clinical outcomes in a prospective observational study

Autor: Cain, Lauren E., Phillips, Andrew, Lodi, Sara, Sabin, Caroline, Bansi, Loveleen, Justice, Amy, Tate, Janet, Logan, Roger, Robins, James M., Sterne, Jonathan A. C., van Sighem, Ard, de Wolf, Frank, Bucher, Heiner C., Elzi, Luigia, Touloumi, Giota, Vourli, Georgia, Esteve, Anna, Casabona, Jordi, del Amo, Julia, Moreno, Santiago, Seng, Rémonie, Meyer, Laurence, Pérez-Hoyos, Santiago, Muga, Roberto, Abgrall, Sophie, Costagliola, Dominique, Hernán, Miguel A., Ainsworth, J., Anderson, J., Babiker, A., Chadwick, D., Delpech, V., Dunn, D., Gras, L. A. J., Prins, J. M., Boer, K., Bos, J. C., Geerlings, S. E., Godfried, M. H., Kuijpers, T. W., Lange, J. M. A., van der Meer, J. T. M., Nellen, F. J. B., Pajkrt, D., van der Poll, T., Reiss, P., Scherpbier, H. J., van der Valk, M., van Vugt, M., Wit, F. W. M. N.

Publikováno v: Aids, 26, 1691-705
AIDS. Official journal of the international AIDS Society
AIDS. Official journal of the international AIDS Society, 2012, 26 (13), pp.1691-705. ⟨10.1097/QAD.0b013e328354f497⟩
AIDS
AIDS, Lippincott, Williams & Wilkins, 2012, 26 (13), pp.1691-705. ⟨10.1097/QAD.0b013e328354f497⟩
AIDS (London, England), 26(13), 1691-1705. Lippincott Williams and Wilkins
Aids, 26, 13, pp. 1691-705
Aids, 26(13), 1691-705. LIPPINCOTT WILLIAMS & WILKINS

Contains fulltext : 109788.pdf (Publisher’s version ) (Closed access) OBJECTIVE: To compare regimens consisting of either efavirenz or nevirapine and two or more nucleoside reverse transcriptase inhibitors (NRTIs) among HIV-infected, antiretroviral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125a911776263172ad8f39a9524582dd
http://hdl.handle.net/2066/109788

Depolarization-induced release of endocannabinoids by murine dorsal motor nucleus of the vagus nerve neurons differentially regulates inhibitory and excitatory neurotransmission

Autor: André Jean, Bruno Lebrun, Jérôme Trouslard, Julien Roux, Nicolas Wanaverbecq

Publikováno v: Neuropharmacology
Neuropharmacology, 2009, 56 (8), pp.1106-15. ⟨10.1016/j.neuropharm.2009.03.009⟩
Neuropharmacology, Elsevier, 2009, 56 (8), pp.1106-15. ⟨10.1016/j.neuropharm.2009.03.009⟩

International audience; Numerous studies, focused on the hypothalamus, have recently implicated endocannabinoids (EC) as orexigenic factors in the central control of food intake. However, the EC system is also highly expressed in the hindbrain autono

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413864ac0e119003d01823190d898cf0
https://hal.science/hal-00417358

Dual Ca2+ modulation of glycinergic synaptic currents in rodent hypoglossal motoneurons

Autor: Mukhtarov, Marat, Ragozzino, Davide, Bregestovski, Piotr

Publikováno v: The Journal of Physiology
The Journal of Physiology, 2005, 569 (Pt 3), pp.817-31. ⟨10.1113/jphysiol.2005.094862⟩
The Journal of Physiology, Wiley, 2005, 569 (Pt 3), pp.817-31. ⟨10.1113/jphysiol.2005.094862⟩

International audience; Glycinergic synapses are implicated in the coordination of reflex responses, sensory signal processing and pain sensation. Their activity is pre- and postsynaptically regulated, although mechanisms are poorly understood. Using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d49fa76eaf03e4629d52f8730be57a6b
http://hdl.handle.net/11573/48844