The effect of B-cell depletion therapy on serological evidence of B-cell and plasmablast activation in patients with rheumatoid arthritis over multiple cycles of rituximab treatment

Autor: Guy Serre, J. C. W. Edwards, H.C. Perry, I. de la Torre, Leonor Nogueira, M.C. Dickson, Maria J. Leandro, HM Parsons, Geraldine Cambridge

Publikováno v: Journal of Autoimmunity
Journal of Autoimmunity, Elsevier, 2014, 50, pp.67-76. ⟨10.1016/j.jaut.2013.12.002⟩

International audience; B-cell depletion therapy (BCDT) based on rituximab (RTX) induces clinical remission in a majority of seropositive patients with Rheumatoid arthritis (RA). However, all patients eventually relapse. The aim of this study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62efc3c35bba328f68bef278cbb6ffe0
https://pubmed.ncbi.nlm.nih.gov/24365380

Identification of patients with indolent B cell lymphoma sensitive to rituximab monotherapy

Autor: Christophe Jamin, Pierre Youinou, Solène Querellou, Christian Berthou, Pascal Hutin, Yves Renaudineau, Boutahar Bendaoud, Jacques-Olivier Pers, Divi Cornec, Adrian Tempescul

Publikováno v: Annals of Hematology
Annals of Hematology, Springer Verlag, 2012, 91 (5), pp.715-21. ⟨10.1007/s00277-011-1369-y⟩

International audience; The potential predictive value of tumor bulk, genetic, and immunological variants in patients with low-grade non-Hodgkin's lymphoma to respond to treatment with rituximab (RTX) monotherapy was evaluated. Thus, the value of ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8aa2ed07be7adbb9f82c04b07c2ec5
https://hal.univ-brest.fr/hal-00771121

B-lymphocytes govern the pathogenesis of Sjögren's syndrome

Autor: Jacques-Olivier Pers, Alain Saraux, Pierre Youinou

Publikováno v: 2012, 13 (10), pp.2071-7

International audience; T cells have originally occupied central stage of the debate on the type of lymphocytes governing the pathogenesis of Sjögren's syndrome (SS). However, B cells has since been substituted for T cells, and insights into their f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b26735debc8d8a3e93c200b38f608b
https://hal.univ-brest.fr/hal-00771052

Markers of B-lymphocyte activation are elevated in patients with early rheumatoid arthritis and correlated with disease activity in the ESPOIR cohort

Autor: Bernard Combe, Beatrice Ducot, Xavier Mariette, Corinne Miceli-Richard, Jacques-Eric Gottenberg, Philippe Goupille

Publikováno v: Arthritis Research and Therapy
Arthritis Research and Therapy, BioMed Central, 2009, 11 (4), pp.R114. ⟨10.1186/ar2773⟩
Arthritis Research & Therapy
Arthritis Research and Therapy, 2009, 11 (4), pp.R114. ⟨10.1186/ar2773⟩

International audience; INTRODUCTION: Little is known about systemic B-cell activation in early rheumatoid arthritis (RA). We therefore evaluated the serum levels of markers of B-cell activation in patients included in the ESPOIR early arthritis coho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11bd91c9f7034a7c8c8f387df15d0049
https://www.hal.inserm.fr/inserm-00663622/file/ar2773.pdf

A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

Autor: Jun Li, Sylvain Perruche, Yongzhong Liu, Pin Zhang, Wanjun Chen, Ashok B. Kulkarni

Publikováno v: Nature Immunology
Nature Immunology, Nature Publishing Group, 2008, 9 (6), pp.632-40. ⟨10.1038/ni.1607⟩

International audience; The molecular mechanisms directing the development of 'natural' CD4+CD25+Foxp3+ regulatory T cells (T(reg) cells) in the thymus are not thoroughly understood. We show here that conditional deletion of transforming growth facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1feb047b7c4bd3fca7d7d714eb8ef478
https://pubmed.ncbi.nlm.nih.gov/18438410