Výsledky vyhledávání - "MESH: Arthritis, Rheumatoid / genetics"

Deimination, Intermediate Filaments and Associated Proteins

Autor: Briot, Julie, Simon, Michel, Méchin, Marie-Claire

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 8746, p 8746 (2020)
International Journal of Molecular Sciences, 2020, 21 (22), pp.8746. ⟨10.3390/ijms21228746⟩
International Journal of Molecular Sciences, MDPI, 2020, 21 (22), pp.8746. ⟨10.3390/ijms21228746⟩

International audience; Deimination (or citrullination) is a post-translational modification catalyzed by a calcium-dependent enzyme family of five peptidylarginine deiminases (PADs). Deimination is involved in physiological processes (cell different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dea2c1fa620f63c25246da202a39d52b
https://pubmed.ncbi.nlm.nih.gov/33228136

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Anticitrullinated protein/peptide antibody multiplexing defines an extended group of ACPA-positive rheumatoid arthritis patients with distinct genetic and environmental determinants

Autor: Guy Serre, Karl Skriner, Evan Reed, Johan Rönnelid, Per-Johan Jakobsson, Martin Cornillet, Monika Hansson, Lars Klareskog, Karin Lundberg, Rikard Holmdahl, Linda Mathsson-Alm, Lars Alfredsson

Publikováno v: Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2018, 77 (2), pp.203-211. ⟨10.1136/annrheumdis-2017-211782⟩

IntroductionThe second generation anticycliccitrullinated peptide (anti-CCP2) assay detects the majority but not all anticitrullinated protein/peptide antibodies (ACPA). Anti-CCP2-positive rheumatoid arthritis (RA) is associated with HLA-DRB1* shared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfbaaa7dd9cf501ddb0774df7d806b4
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03371163

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In Black Africans with rheumatoid arthritis, ACPA recognize citrullinated fibrinogen and the derived peptides α36-50Cit38,42 and β60-74Cit60,72,74, like in Caucasians

Autor: Sylvette Bas, Leonor Nogueira, Madeleine Singwe-Ngandeu, Guy Serre, Cem Gabay, Martin Cornillet, Sebastien Viatte

Publikováno v: Clinical Immunology
Clinical Immunology, Elsevier, 2014, 152 (1-2), pp.58-64. ⟨10.1016/j.clim.2014.02.011⟩
Clinical Immunology, Vol. 152, No 1-2 (2014) pp. 58-64

International audience; Well documented in Caucasians and Asians, the diagnostic value of anti-CCP2 antibodies has been confirmed in Black African populations. However, autoantibodies to other citrullinated peptides/proteins and their fine specificit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e015e6a4a675d50b46141093a618b4fb
https://doi.org/10.1016/j.clim.2014.02.011

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The effect of B-cell depletion therapy on serological evidence of B-cell and plasmablast activation in patients with rheumatoid arthritis over multiple cycles of rituximab treatment

Autor: Guy Serre, J. C. W. Edwards, H.C. Perry, I. de la Torre, Leonor Nogueira, M.C. Dickson, Maria J. Leandro, HM Parsons, Geraldine Cambridge

Publikováno v: Journal of Autoimmunity
Journal of Autoimmunity, Elsevier, 2014, 50, pp.67-76. ⟨10.1016/j.jaut.2013.12.002⟩

International audience; B-cell depletion therapy (BCDT) based on rituximab (RTX) induces clinical remission in a majority of seropositive patients with Rheumatoid arthritis (RA). However, all patients eventually relapse. The aim of this study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62efc3c35bba328f68bef278cbb6ffe0
https://pubmed.ncbi.nlm.nih.gov/24365380

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