Treating leishmaniasis in Amazonia, part 2: Multi-target evaluation of widely used plants to understand medicinal practices

Autor: Emeline Houël, Marine Ginouves, Nadine Azas, Eliane Bourreau, Véronique Eparvier, Sébastien Hutter, Adeline Knittel-Obrecht, Arnaud Jahn-Oyac, Ghislaine Prévot, Pascal Villa, Catherine Vonthron-Sénécheau, Guillaume Odonne

Publikováno v: Journal of Ethnopharmacology
Journal of Ethnopharmacology, 2022, 289, pp.115054. ⟨10.1016/j.jep.2022.115054⟩
Journal Of Ethnopharmacology (0378-8741) (Elsevier BV), 2022-05, Vol. 289, P. 115054 (17p.)

International audience; Ethnopharmacological relevanceLeishmaniasis are widely distributed among tropical and subtropical countries, and remains a crucial health issue in Amazonia. Indigenous groups across Amazonia have developed abundant knowledge a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd157958f1c7cb10db48929e354b91f6
https://amu.hal.science/hal-03678995

Metabolomic approach of the antiprotozoal activity of medicinal Piper species used in Peruvian Amazon

Autor: Wilfredo Ruiz Mesía, Liliana Ruiz-Vásquez, Sandrine Cojean, Bruno Figadère, Pedro Vásquez-Ocmín, Alice Gadea, Anne-Cécile Van Baelen, Sébastien Pomel, Alexandre Maciuk, Lastenia Ruiz Mesía, Guillaume Marti

Publikováno v: Journal of Ethnopharmacology
Journal of Ethnopharmacology, Elsevier, 2021, 264, pp.113262. ⟨10.1016/j.jep.2020.113262⟩
Journal of Ethnopharmacology, 2021, 264, pp.113262. ⟨10.1016/j.jep.2020.113262⟩

International audience; Ethnopharmacological relevance : In the Peruvian Amazon as in the tropical countries of South America, the use of medicinal Piper species (cordoncillos) is common practice, particularly against symptoms of infection by protozo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a812ab05d9207b094a8795f6c16fd647
https://doi.org/10.1016/j.jep.2020.113262

Treatment with synthetic lipophilic tyrosyl ester controls Leishmania major infection by reducing parasite load in BALB/c mice

Autor: Fatma Z. Guerfali, Hanène Attia, Youssef Gargouri, Pablo A. Leon Martinez, Ghada Mkannez, Aymen Bali, Dhafer Laouini, Imen Aissa, Rabiaa M. Sghaier

Publikováno v: Parasitology
Parasitology, Cambridge University Press (CUP), 2016, 143 (12), pp.1615-1620. ⟨10.1017/S0031182016001086⟩

SUMMARYSynthesized lipophilic tyrosyl ester derivatives with increasing lipophilicity were effective against Leishmania (L.) major and Leishmania infantum species in vitro. These findings prompted us to test in vivo leishmanicidal properties of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bc2abccdcddddc96eac44eca020091
https://doi.org/10.1017/s0031182016001086

Presence of Leishmania RNA Virus 1 in Leishmania guyanensis Increases the Risk of First-Line Treatment Failure and Symptomatic Relapse

Autor: Dominique Sainte-Marie, Nicolas Fasel, Pierre Couppié, Ricardo Martin, Frédéric Schütz, Florence Robert-Gangneux, Antoine Bertolotti, Catherine Ronet, Mary-Anne Hartley, Marine Ginouves, Ghislaine Prévot, Francine Pratlong, J. Dufour, Eliane Bourreau, Jean-Pierre Gangneux

Publikováno v: Journal of Infectious Diseases
Journal of Infectious Diseases, 2016, 213 (1), pp.105-111. ⟨10.1093/infdis/jiv355⟩
Journal of Infectious Diseases, Oxford University Press (OUP), 2016, 213 (1), pp.105-111. ⟨10.1093/infdis/jiv355⟩

International audience; Treatment failure and symptomatic relapse are major concerns in American tegumentary leishmaniasis (TL). Such complications are seen frequently in Leishmania guyanensis infections, in which patients respond variously to first-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb972dea50a3b696f8fe15a792e41637
https://univ-rennes.hal.science/hal-01175528

The enemy within: Targeting host–parasite interaction for antileishmanial drug discovery

Autor: Eric Prina, Najma Rachidi, Gerald F. Späth, Suzanne Lamotte

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2017, 11 (6), pp.e0005480. ⟨10.1371/journal.pntd.0005480⟩
PLOS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, 2017, 11 (6), pp.e0005480. ⟨10.1371/journal.pntd.0005480⟩
PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005480 (2017)

International audience; The state of antileishmanial chemotherapy is strongly compromised by the emergence of drug-resistant Leishmania. The evolution of drug-resistant phenotypes has been linked to the parasites’ intrinsic genome instability, with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547b6df90b34fd156ee577c323382b33
https://hal-pasteur.archives-ouvertes.fr/pasteur-01570238/document