Výsledky vyhledávání - "MESH: Antineoplastic Agents/pharmacology"

Evaluation of anti-diabetic and anti-tumoral activities of bioactive compounds from Phoenix dactylifera L's leaf: In vitro and in vivo approach

Autor: Mohamed Bouaziz, Mohamed Makni, Naziha Marrakchi, Bassem Khemakhem, M Chakroun, Hazem Ben Mabrouk, Noureddine Drira, Hanen El Abed, Hafedh Mejdoub

Publikováno v: Biomedicine and Pharmacotherapy
Biomedicine and Pharmacotherapy, Elsevier Masson, 2016, 84, pp.415-422. ⟨10.1016/j.biopha.2016.09.062⟩

International audience; Among various chronic disorders, cancer and diabetes mellitus are the most common disorders. This study was designed to evaluate the effectiveness of hydroalcoholic extract of Phoenix dactylifera L. leaves (HEPdL) in animal mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637af2e2c971453a10bdd415909862d2
https://pubmed.ncbi.nlm.nih.gov/27668542

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Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression

Autor: Ons, Zakraoui, Cezary, Marcinkiewicz, Zohra, Aloui, Houcemeddine, Othman, Renaud, Grépin, Meriam, Haoues, Makram, Essafi, Najet, Srairi-Abid, Ammar, Gasmi, Habib, Karoui, Gilles, Pagès, Khadija, Essafi-Benkhadir

Publikováno v: Molecular Carcinogenesis
Molecular Carcinogenesis, Wiley, 2016, 56, pp.18-35. ⟨10.1002/mc.22470⟩

Lebein, is an heterodimeric disintegrin isolated from Macrovipera lebetina snake venom that was previously characterized as an inhibitor of ADP-induced platelet aggregation. In this study, we investigated the effect of Lebein on the p53-dependent gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0f26039872eae3cfc403bba0d6257ac7
https://hal.archives-ouvertes.fr/hal-01356511

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Proteasome inhibitor-induced apoptosis in acute myeloid leukemia: A correlation with the proteasome status

Autor: Odile Burlet-Schiltz, Bernard Monsarrat, Stéphane Manenti, Marie-Pierre Bousquet-Dubouch, Mariette Matondo, Christian Recher, Sandrine Uttenweiler-Joseph, Bernard Payrastre, Nathalie Gallay

Publikováno v: Leukemia Research
Leukemia Research, Elsevier, 2010, 34 (4), pp.498-506. ⟨10.1016/j.leukres.2009.09.020⟩

International audience; The proteasome plays a critical role in the regulation of many cellular processes, including the cell cycle and tumor growth. The proteasome inhibitor bortezomib has recently been approved for the treatment of relapsed and ref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c9c627ffc922f7fa4dfe1b585c758e
https://doi.org/10.1016/j.leukres.2009.09.020

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Quilamine HQ1-44, an iron chelator vectorized toward tumor cells by the polyamine transport system, inhibits HCT116 tumor growth without adverse effect

Autor: Olivier Loréal, Martine Ropert, François Gaboriau, Sylvie Lepage, Vincent Corcé, Isabelle Cannie, David Deniaud, Stéphanie Renaud

Publikováno v: Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2015, 96 (3), pp.179-189. ⟨10.1016/j.bcp.2015.06.001⟩
Biochemical Pharmacology, 2015, 96 (3), pp.179-189. ⟨10.1016/j.bcp.2015.06.001⟩

International audience; Tumor cell growth requires large iron quantities and the deprivation of this metal induced by synthetic metal chelators is therefore an attractive method for limiting the cancer cell proliferation. The antiproliferative effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca8eaeacdc2a079dd88d9dcdf99544b
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01163245/document

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HER3 as biomarker and therapeutic target in pancreatic cancer: new insights in pertuzumab therapy in preclinical models

Autor: Thomas, Gaëlle, Chardès, Thierry, Gaborit, Nadège, Mollevi, Caroline, Leconet, Wilhem, Robert, Bruno, Kharrat, Abdelhakim, Radosevic-Robin, Nina, Penault-Llorca, Frédérique, Gongora, Céline, Colombo, Pierre-Emmanuel, Lazrek, Yassamine, Bras-Goncalves, Rui, Savina, Ariel, Azria, David, Bazin, Hervé, Pèlegrin, André, Larbouret, Christel

Publikováno v: Oncotarget
Oncotarget, Impact journals, 2014, 5 (16), pp.7138-7148. ⟨10.18632/oncotarget.2231⟩
Oncotarget, 2014, 5 (16), pp.7138-7148. ⟨10.18632/oncotarget.2231⟩
Oncotarget, Impact journals, 2014, 5 (16), pp.7138-48. ⟨10.18632/oncotarget.2231⟩

// Gaelle Thomas 1,2 , Thierry Chardes 1 , Nadege Gaborit 1 , Caroline Mollevi 5 , Wilhem Leconet 1 , Bruno Robert 1 , Nina Radosevic-Robin 3 , Frederique Penault-Llorca 3 , Celine Gongora 1 , Pierre-Emmanuel Colombo 1 , Yassamine Lazrek 1,4 , Rui Br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f04599cb652199243301a9a7701e65
https://hal.uca.fr/hal-02387994

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[Effect of Macrovipera lebetina and Cerastes cerastes venoms on adherence to integrins of cancerous cells (IGR39, HT29-D4 and IGROV1)]

Autor: Marrakchi, N, Sarray, S, Marvaldi, J, EL Ayeb, M, Luis, J

Publikováno v: Archives de l'Institut Pasteur de Tunis
Archives de l'Institut Pasteur de Tunis, 2002, 79 (1-4), pp.3--9

In this work, we provide experimental arguments in favor of the fact that components from Macrovipera lebetina and Cerastes cerastes venoms bind to IGR39 melanoma cells but not to HT29D4 cells that derive from carcinoma adenome. Furthermore, Macrovip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f4f8046bcef43ab7d7c27c40052819e6
https://hal.archives-ouvertes.fr/hal-01975005

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Inhibition of P-glycoprotein: rapid assessment of its implication in blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier

Autor: Fenart, Laurence, Buée-Scherrer, Valérie, Descamps, Laurence, Duhem, Christian, Poullain, Marie-Gwenaëlle, Cecchelli, Roméo, Dehouck, Marie-Pierre

Publikováno v: Pharmaceutical Research
Pharmaceutical Research, American Association of Pharmaceutical Scientists, 1998, 15 (7), pp.993-1000. ⟨10.1023/a:1011913723928⟩
Pharmaceutical Research, 1998, 15 (7), pp.993-1000. ⟨10.1023/a:1011913723928⟩

International audience; Purpose. The objective of this work was to asses, in vitro, the passage of P-glycoprotein dependent drugs across brain capillary endothelial cells, when these drugs are associated with a reversing agents. Methods. An in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2abbda19f20682d1ee2aa3db16289ef9
https://hal-univ-artois.archives-ouvertes.fr/hal-00531737

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