Výsledky vyhledávání - "MESH: Antibodies, Blocking"

Amplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunity

Autor: Lenore L. Carias, Benoit Witkowski, Saorin Kim, Christopher L. King, Camille Roesch, Nimol Khim, Ivo Mueller, Chetan E. Chitnis, Jean Popovici, Amélie Vantaux

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.953. ⟨10.1038/s41467-020-14574-9⟩
Nature Communications, 2020, 11 (1), pp.953. ⟨10.1038/s41467-020-14574-9⟩

Antigenic variation, the capacity to produce a range of variable antigens, is a well-described strategy of Plasmodium and other parasites to evade host immunity. Here, we show that gene amplification is an additional evasion mechanism used by Plasmod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc00eb99965ad87ce36544f98cc6415
https://doaj.org/article/cf65b319fe4a4e48a9d32fb245c93fef

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Development of neutralizing scFv-Fc against botulinum neurotoxin A light chain from a macaque immune library

Autor: Thomas Schirrmann, Yvonne Liu, Sebastian Miethe, André Frenzel, Christine Rasetti-Escargueil, Philippe Thullier, Arnaud Avril, Dorothea Sesardic, Michael Hust, Thibaut Pelat, Siham Chahboun

Publikováno v: mAbs
mAbs, Taylor & Francis, 2014, 6 (2), pp.446-459. ⟨10.4161/mabs.27773⟩

International audience; Botulinum toxins (BoNTs) are among the most toxic substances on earth, with serotype A toxin being the most toxic substance known. They are responsible for human botulism, a disease characterized by flaccid muscle paralysis th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b79c4b03277782d941f11d6ab9496dc
https://pubmed.ncbi.nlm.nih.gov/24492304

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Cutting Edge: FcγRIII (CD16) and FcγRI (CD64) Are Responsible for Anti-Glycoprotein 75 Monoclonal Antibody TA99 Therapy for Experimental Metastatic B16 Melanoma

Autor: Pierre Bruhns, Andrew J. Murphy, Marcello Albanesi, Laurence Zitvogel, Jeanette H. W. Leusen, Bruno Iannascoli, David A. Mancardi, Macdonald Lynn

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2012, 189 (12), pp.5513-5517. ⟨10.4049/jimmunol.1201511⟩
Journal of Immunology, 2012, 189 (12), pp.5513-5517. ⟨10.4049/jimmunol.1201511⟩

Erratum in J Immunol. 2013 Feb 1;190(3):1381. Daëron, Marc [added].; International audience; mAb therapy for experimental metastatic melanoma relies on activating receptors for the Fc portion of IgG (FcγR). Opposing results on the respective contri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256c4a6a46e500b8db1c34d71a379d57
https://doi.org/10.4049/jimmunol.1201511

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The use of TNF-α blocking agents in rheumatoid arthritis: an update

Autor: Eric, Toussirot, Daniel, Wendling

Publikováno v: Expert Opinion on Pharmacotherapy
Expert Opinion on Pharmacotherapy, Taylor & Francis, 2007, 8 (13), pp.2089-107. ⟨10.1517/14656566.8.13.2089⟩

International audience; TNF-alpha has been found to play a pivotal role in the pathogenic mechanisms of rheumatoid arthritis (RA). Drugs targeting TNF-alpha have been developed to neutralise the deleterious effects of this inflammatory cytokine. Ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0bb2de28cff177530ce65c2133e734
https://doi.org/10.1517/14656566.8.13.2089

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Gene expression profiling identifies sST2 as an effector of ErbB2-driven breast carcinoma cell motility, associated with metastasis

Autor: B. Duthey, François Bertucci, David Jérémie Birnbaum, Thérèse Gargi, Danièle Salaün, Ali Badache, Olivier Tredan, Pascal Finetti, Nathalie Bendriss-Vermare, J. Gillibert-Duplantier, Vanja Sisirak

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2012, 31 (30), pp.3516-24. 〈10.1038/onc.2011.525〉
Oncogene, Nature Publishing Group, 2012, 31 (30), pp.3516-24. ⟨10.1038/onc.2011.525⟩

International audience; Overexpression of the ErbB2 receptor tyrosine kinase in breast cancer contributes to tumor development and is associated with poor prognosis. However, the mechanism by which ErbB2 might contribute to metastasis is not well def

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14acb203a22f05348f6eabb24473f1e8
https://hal.archives-ouvertes.fr/hal-00820060

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Inflammation of choriodecidua induces tumor necrosis factor alpha-mediated apoptosis of human myometrial cells

Autor: Leroy , Marie-Josèphe, Dallot , Emmanuelle, Czerkiewicz , Isabelle, Schmitz , Thomas, Breuiller-Fouché , Michelle

Publikováno v: Biology of Reproduction
Biology of Reproduction, 2007, 76 (5), pp.769-76. ⟨10.1095/biolreprod.106.058057⟩
Biology of Reproduction, Society for the Study of Reproduction, 2007, 76 (5), pp.769-76. ⟨10.1095/biolreprod.106.058057⟩
Biology of Reproduction, Society for the Study of Reproduction, 2007, 76 (5), pp.769-76. 〈10.1095/biolreprod.106.058057〉

The present study investigated the ability of human choriodecidua to induce myometrial cell apoptosis through the secretion of tumor necrosis factor alpha (TNF). The secretion of TNF was evaluated in the culture supernatants of amnion and choriodecid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bae221fbfe8ad195c16607e7d650329c
https://doi.org/10.1095/biolreprod.106.058057

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Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses

Autor: Bruce Beutler, Marta Gut, Sam Kung, Bernard Malissen, Claire Bernat, Simon Heath, Marie Malissen, Eric Vivier, Jordi Estellé, Frédéric Vély, Aude De Gassart, Louis Noël Gastinel, Emilie Narni-Mancinelli, Aurore Fenis, Sophie Ugolini, Baptiste N. Jaeger, Elodie Bertosio, Sajid Mahmood, Ivo Gut

Publikováno v: Science
Science, 2012, 335 (6066), pp.344-8. ⟨10.1126/science.1215621⟩
Science, American Association for the Advancement of Science, 2012, 335 (6066), pp.344-8. ⟨10.1126/science.1215621⟩

Natural Killer Controls Cytolytic natural killer (NK) cells participate in both antimicrobial and antitumor immunity. Their responsiveness is tuned through signals received through a variety of inhibitory and activating receptors expressed on their c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c61a2cefddca2c3e41964c187e29aa
https://pubmed.ncbi.nlm.nih.gov/22267813

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EMMPRIN (CD147) regulation of MMP-9 in bronchial epithelial cells in COPD

Autor: Jouneau, Stephane, Khorasani, Nadia, de Souza, Patricia, Macedo, Patricia, Zhu, Jie, Bhavsar, Pankaj K, Chung, Kian F

Publikováno v: Respirology
Respirology, Wiley, 2011, 16 (4), pp.705-12. ⟨10.1111/j.1440-1843.2011.01960.x⟩
Respirology, 2011, 16 (4), pp.705-12. ⟨10.1111/j.1440-1843.2011.01960.x⟩

International audience; BACKGROUND AND OBJECTIVE: Extracellular matrix metalloproteinase inducer (EMMPRIN or CD147) induces the production of matrix metalloproteinases (MMP) such as MMP-9, which plays an important role in COPD. We determined its cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::811c024f82237d47792e193a902f629d
https://hal.archives-ouvertes.fr/hal-00873269

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Constant tcr triggering suggests that the tcr expressed on intestinal intraepithelial gamma delta t cells is functional in vivo

Autor: Bernard Malissen, Frano H. Malinarich, Rodrigo Quera, Elena Grabski, Susanne Schmitz, Jan D. Haas, Immo Prinz, Reinhold Förster, Enzo Candia, Marcela A. Hermoso, Tim Worbs, Vijaykumar Chennupati

Publikováno v: EUROPEAN JOURNAL OF IMMUNOLOGY
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
European Journal of Immunology
European Journal of Immunology, 2010, 40 (12), pp.3378-88. ⟨10.1002/eji.201040727⟩
European Journal of Immunology, Wiley-VCH Verlag, 2010, 40 (12), pp.3378-88. ⟨10.1002/eji.201040727⟩

International audience; Intestinal intraepithelial lymphocytes carrying the γδ TCR (γδ iIEL) are involved in the maintenance of epithelial integrity. γδ iIEL have an activated phenotype, characterized by CD69 expression and increased cell size

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecea30ea175c575c277b9fa0e8af1012

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Immune Activation Driven by CTLA-4 Blockade Augments Viral Replication at Mucosal Sites in Simian Immunodeficiency Virus Infection

Autor: David Venzon, Jean-Michel Heraud, Richard A. Koup, Zhong-Min Ma, Elzbieta Tryniszewska, Constantinos Petrovas, Dietmar Fuchs, Christopher J. Miller, Genoveffa Franchini, Gene M. Shearer, Monica Vaccari, Valentina Cecchinato, Adriano Boasso, Wen-Po Tsai, Israel Lowy

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2008, 180 (8), pp.5439-5447. ⟨10.4049/jimmunol.180.8.5439⟩
Scopus-Elsevier

The importance of chronic immune activation in progression to AIDS has been inferred by correlative studies in HIV-infected individuals and in nonhuman primate models of SIV infection. Using the SIVmac251 macaque model, we directly address the impact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb882206503cedafab0a812866fa232d
https://hal-pasteur.archives-ouvertes.fr/pasteur-03380767

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