S-Trityl-L-cysteine Is a Reversible, Tight Binding Inhibitor of the Human Kinesin Eg5 That Specifically Blocks Mitotic Progression

Autor: Richard H. Wade, Luc Lebeau, Dimitrios A. Skoufias, Robert A. Cross, Yasmina Saoudi, Isabelle Crevel, Salvatore DeBonis, Frank Kozielski, David D. Hackney

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 281 (26), pp.17559-69. ⟨10.1074/jbc.M511735200⟩
Journal of Biological Chemistry, 2006, 281 (26), pp.17559-69. ⟨10.1074/jbc.M511735200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 281 (26), pp.17559-17569. ⟨10.1074/jbc.M511735200⟩
Journal of Biological Chemistry, 2006, 281 (26), pp.17559-17569. ⟨10.1074/jbc.M511735200⟩

International audience; Human Eg5, responsible for the formation of the bipolar mitotic spindle, has been identified recently as one of the targets of S-trityl-L-cysteine, a potent tumor growth inhibitor in the NCI 60 tumor cell line screen. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0790f52cce3de6bd078d82b6d2e5c4cf
https://doi.org/10.1074/jbc.m511735200