Small-RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants

Autor: Blaise Li, Martino Ugolini, Damarys Loew, Germano Cecere, Aleksei Samolygo, Céline Didier, Eric Cornes, Meetali Singh, Giorgia Barucci, Piergiuseppe Quarato, Florent Dingli

Publikováno v: Nature cell biology
Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2020, 22 (2), pp.235-245. ⟨10.1038/s41556-020-0462-7⟩
Nature Cell Biology, 2020, 22 (2), pp.235-245. ⟨10.1038/s41556-020-0462-7⟩

International audience; PIWI-interacting RNAs (piRNAs) promote fertility in many animals. However, whether this is due to their conserved role in repressing repetitive elements (REs) remains unclear. Here, we show that the progressive loss of fertili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983b418c96155c11b9d0637d29c2e4f8
https://doi.org/10.1038/s41556-020-0462-7

Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson’s disease

Autor: Victor, Girard, Florence, Jollivet, Oskar, Knittelfelder, Marion, Celle, Jean-Noel, Arsac, Gilles, Chatelain, Daan M, Van den Brink, Thierry, Baron, Andrej, Shevchenko, Ronald P, Kühnlein, Nathalie, Davoust, Bertrand, Mollereau

Publikováno v: PLoS Genetics
PLoS Genetics, 2021, 17 (11), pp.e1009921. ⟨10.1371/journal.pgen.1009921⟩
PLoS Genetics, Vol 17, Iss 11, p e1009921 (2021)

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by alpha-synuclein (αSyn) aggregation and associated with abnormalities in lipid metabolism. The accumulation of lipids in cytoplasmic organelles called lipid droplets (LDs) wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9f1e6dded1ebac0cdf8010832878ee7c
https://hal-anses.archives-ouvertes.fr/anses-04041023

A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila

Autor: Babski, H., Jovanic, Tihana, Surel, C., Yoshikawa, S., Zwart, M., Valmier, J., Thomas, J., Enriquez, J., Carroll, P., Garces, A.

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10, pp.4796. ⟨10.1038/s41467-019-12693-6⟩
Nature Communications, 2019, 10, pp.4796. ⟨10.1038/s41467-019-12693-6⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.4796. ⟨10.1038/s41467-019-12693-6⟩
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

Interneurons (INs) coordinate motoneuron activity to generate appropriate patterns of muscle contractions, providing animals with the ability to adjust their body posture and to move over a range of speeds. In Drosophila larvae several IN subtypes ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::954da7c54c09af216be00b6dfc31a03e
https://hal.archives-ouvertes.fr/hal-02379734/file/s41467-019-12693-6.pdf

Neural stem cell quiescence and stemness are molecularly distinct outputs of the Notch3 signalling cascade in the vertebrate adult brain

Autor: Than-Trong, Emmanuel, Ortica-Gatti, Sara, Mella, Sébastien, Nepal, Chirag, Alunni, Alessandro, Bally-Cuif, Laure

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2018, 145 (10), pp.dev161034. ⟨10.1242/dev.161034⟩
Than-Trong, E, Ortica-Gatti, S, Mella, S, Nepal, C, Alunni, A & Bally-Cuif, L 2018, ' Neural stem cell quiescence and stemness are molecularly distinct outputs of the notch3 signalling cascade in the vertebrate adult brain ', Development (Cambridge), vol. 145, no. 10, dev161034, pp. 1-14 . https://doi.org/10.1242/dev.161034
Development (Cambridge, England), 2018, 145 (10), pp.dev161034. ⟨10.1242/dev.161034⟩

International audience; Neural stem cells (NSCs) in the adult vertebrate brain are found in a quiescent state and can preserve long-lasting progenitor potential (stemness). Whether and how these two properties are linked, and to what extent they can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f0cef0cd1f5eb6a72f40a86ac505e7d9
https://hal.archives-ouvertes.fr/hal-02372773

Variations in basement membrane mechanics are linked to epithelial morphogenesis

Autor: Gaël Runel, Arezki Boudaoud, Muriel Grammont, Pascale Milani, Laurie-Anne Lamire, Julien Chlasta, Leticia Arias, Jean-Luc Duteyrat

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2017, 144 (23), pp.4350-4362. ⟨10.1242/dev.152652⟩
Development (Cambridge, England), 2017, 144 (23), pp.4350-4362. ⟨10.1242/dev.152652⟩

International audience; The regulation of morphogenesis by the basement membrane (BM) may rely on changes in its mechanical properties. To test this, we developed an atomic force microscopy-based method to measure BM mechanical stiffness during two k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8348303168330a277101cb2368713d
https://hal.archives-ouvertes.fr/hal-03023256