Zobrazeno 1 - 10 of 29 pro vyhledávání: '"MESH: Amyloid beta-Protein Precursor"'
1
Specific Mutations in the Cholesterol-Binding Site of APP Alter Its Processing and Favor the Production of Shorter, Less Toxic Aβ Peptides
Autor: Linda Hanbouch, Béatrice Schaack, Amal Kasri, Gaëlle Fontaine, Eleni Gkanatsiou, Gunnar Brinkmalm, Elena Camporesi, Erik Portelius, Kaj Blennow, Gilles Mourier, Nicolas Gilles, Mark J. Millan, Catherine Marquer, Henrik Zetterberg, Lydie Boussicault, Marie-Claude Potier
Publikováno v: Molecular Neurobiology
Molecular Neurobiology, 2022, 59 (11), pp.7056-7073. ⟨10.1007/s12035-022-03025-9⟩
Excess brain cholesterol is strongly implicated in the pathogenesis of Alzheimer disease (AD). Here we evaluated how the presence of a cholesterol-binding site (CBS) in the transmembrane and juxtamembrane regions of the amyloid precursor protein (APP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f7066ea0428397b2d6e60f8515d31d
https://hal.science/hal-03808051
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2
A shared disease-associated oligodendrocyte signature among multiple CNS pathologies
Autor: Kenigsbuch, Mor, Bost, Pierre, Halevi, Shahar, Chang, Yuzhou, Chen, Shuo, Ma, Qin, Hajbi, Renana, Schwikowski, Benno, Bodenmiller, Bernd, Fu, Hongjun, Schwartz, Michal, Amit, Ido
Publikováno v: Nature Neuroscience, 25 (7)
Nat Neurosci
Nature Neuroscience
Nature Neuroscience, 2022, 25 (7), pp.876-886. ⟨10.1038/s41593-022-01104-7⟩
Alzheimer’s disease (AD) is a complex neurodegenerative disease, perturbing neuronal and non-neuronal cell populations. In this study, using single-cell transcriptomics, we mapped all non-immune, non-neuronal cell populations in wild-type and AD mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4990374e050ef17c30921b049575e0
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3
Causative Mutations and Genetic Risk Factors in Sporadic Early Onset Alzheimer’s Disease Before 51 Years
Autor: Aline Zarea, Eloi Magnin, Stéphane Epelbaum, Claire Paquet, Valérie Chauviré, Florence Pasquier, Anne Boland, Marie Sarazin, David Wallon, Bruno Salomon, Dominique Campion, Olivier Godefroy, Olivier Martinaud, Mathilde Sauvée, Sophie Auriacombe, Cecilia Marelli, Frédérique Etcharry-Bouyx, Gaël Nicolas, Jean-François Deleuze, Anne-Claire Richard, Vincent de la Sayette, Audrey Gabelle, Thérèse Rivasseau Jonveaux, Stéphane Rousseau, Jérémie Pariente, Mathieu Ceccaldi, Maïté Formaglio, Anne Rovelet-Lecrux, Didier Hannequin, Adeline Rollin-Sillaire, Bernard Croisile, Isabelle Le Ber, Morgane Lacour, Olivier Quenez, Olivier Rouaud, Muriel Quillard-Muraine, Claire Boutoleau-Bretonnière
Publikováno v: Journal of Alzheimer's Disease
Journal of Alzheimer's Disease, IOS Press, 2019, 71 (1), pp.227-243. ⟨10.3233/JAD-190193⟩
Journal of Alzheimer's Disease, 2019, 71 (1), pp.227-243. ⟨10.3233/JAD-190193⟩
International audience; Background:Pathogenic variants in the autosomal dominant genes PSEN1, PSEN2, or APP, APOE4 alleles, and rare variants within TREM2, SORL1, and ABCA7 contribute to early-onset Alzheimer’s disease (EOAD). However, sporadic EOA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79fd1ec366fdec9dc8bd5fd95bcb114
https://hal-normandie-univ.archives-ouvertes.fr/hal-02332506
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4
APP‐dependent glial cell line‐derived neurotrophic factor gene expression drives neuromuscular junction formation
Autor: Stanga, Serena, Zanou, Nadège, Audouard, Emilie, Tasiaux, Bernadette, Contino, Sabrina, Vandermeulen, Gaëlle, René, Frédérique, Loeffler, Jean-Philippe, Clotman, Frédéric, Gailly, Philippe, Dewachter, Ilse, Octave, Jean-Noël, Kienlen-Campard, Pascal, Loeffler, Jean‐philippe, Dewachter, Use, Octave, Jean‐noël, Kienlen‐campard, Pascal
Publikováno v: FASEB Journal
FASEB Journal, 2016, 30 (5), pp.1696-1711. ⟨10.1096/fj.15-278739⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2016, 30 (5), pp.1696-1711. ⟨10.1096/fj.15-278739⟩
Article
Besides its crucial role in the pathogenesis of Alzheimer's disease, the knowledge of amyloid precursor protein (APP) physiologic functions remains surprisingly scarce. Here, we show that APP regulates the transcription of the glial cell line-derived
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684e3c499ee57ad04dc8394f919c61b8
https://www.hal.inserm.fr/inserm-03375186/file/fj.15-278739.pdf
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5
Biochemical Staging of Synucleinopathy and Amyloid Deposition in Dementia With Lewy Bodies
Autor: Claude Alain Maurage, Antoine Ghestem, S. Bombois, Hervé Drobecq, Vincent Deramecourt, Florence Lebert, Florence Pasquier, Eugeen Vanmechelen, André Delacourte
Publikováno v: Journal of Neuropathology and Experimental Neurology
Journal of Neuropathology and Experimental Neurology, Lippincott, Williams & Wilkins, 2006, 65 (3), pp.278-288. ⟨10.1097/01.jnen.0000205145.54457.ea⟩
The primary feature of dementia with Lewy bodies (DLB) is the aggregation of alpha-synuclein into characteristic lesions: Lewy bodies (LBs) and Lewy neurites. However, in most of DLB cases, LBs are associated with neurofibrillary tangles and amyloid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc99649756a02c23cd77e8963a7327c
https://doi.org/10.1097/01.jnen.0000205145.54457.ea
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6
Synapses, NMDA receptor activity and neuronal Aβ production in Alzheimer's disease
Autor: Alain Buisson, Javier Becerril-Ortega, K. Bordji
Publikováno v: Reviews in the Neurosciences
Reviews in the Neurosciences, Walter de Gruyter, 2011, 22 (3), pp.285-94. 〈10.1515/RNS.2011.029〉
Reviews in the Neurosciences, 2011, 22 (3), pp.285-94. ⟨10.1515/RNS.2011.029⟩
Reviews in the Neurosciences, Walter de Gruyter, 2011, 22 (3), pp.285-94. ⟨10.1515/RNS.2011.029⟩
A direct relationship has been established between synaptic activity and amyloid-β secretion. Dysregulation of neuronal calcium homeostasis was shown to increase production of amyloid-β, contributing to the initiation of Alzheimer’s disease. Amon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f147103470d7bf76856a467411da16
http://www.hal.inserm.fr/inserm-00800301/file/Bordji_2011_Synapses_AO.pdf
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7
β-amyloid and ATP-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors
Autor: Shrivastava, Amulya Nidhi, Kowalewski, Jacob M, Renner, Marianne, Bousset, Luc, Koulakoff, Annette, Melki, Ronald, Giaume, Christian, Triller, Antoine
Publikováno v: Glia
Glia, Wiley, 2013, 61 (10), pp.1673-86. ⟨10.1002/glia.22548⟩
β-Amyloid (Aβ) oligomers initiate synaptotoxicity following their interaction with the plasma membrane. Several proteins including metabotropic glutamate type 5 receptors (mGluR5s) contribute to this process. We observed an overexpression of mGluR5
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4626854893ea56eead3245a9a7181426
https://hal.archives-ouvertes.fr/hal-01183377
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8
α-Secretase-derived fragment of cellular prion, N1, protects against monomeric and oligomeric amyloid β (Aβ)-associated cell death
Autor: Claire Sunyach, Charlotte Bauer, Sergio T. Ferreira, Aurelie Thevenet, Marie-Victoire Guillot-Sestier, Maria Paz Marzolo, Frédéric Checler
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (7), pp.5021-32. ⟨10.1074/jbc.M111.323626⟩
JOURNAL OF BIOLOGICAL CHEMISTRY
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
International audience; In physiological conditions, both β-amyloid precursor protein (βAPP) and cellular prion (PrP(c)) undergo similar disintegrin-mediated α-secretase cleavage yielding N-terminal secreted products referred to as soluble amyloid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9bfc3e54618ef29558dcc4270b42ae
https://europepmc.org/articles/PMC3774388/
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9
Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease
Autor: Monica Di Luca, Alerie Guzman de la Fuente, Stefano Musardo, Barbara Borroni, Hugo Vara, Alessandro Padovani, Maurizio Giustetto, Isabel Pérez-Otaño, Silvia Pelucchi, Daniele Di Marino, Claudia Saraceno, Fabrizio Gardoni, Anna Tramontano, Elena Marcello
Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2013, 123 (6), pp.2523-38. ⟨10.1172/JCI65401⟩
International audience; A disintegrin and metalloproteinase 10 (ADAM10), a disintegrin and metalloproteinase that resides in the postsynaptic densities (PSDs) of excitatory synapses, has previously been shown to limit β-amyloid peptide (Aβ) formati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1f609c34540d9af718615d6c3a7e91
https://pubmed.ncbi.nlm.nih.gov/23676497
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10
A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease
Autor: Rovelet-Lecrux, Anne, Legallic, Solenn, Wallon, David, Flaman, Jean-Michel, Martinaud, Olivier, Bombois, Stéphanie, Rollin-Sillaire, Adeline, Michon, Agnès, Le Ber, Isabelle, Pariente, Jérémie, Puel, Michèle, Paquet, Claire, Croisile, Bernard, Thomas-Antérion, Catherine, Vercelletto, Martine, Lévy, Richard, Frébourg, Thierry, Hannequin, Didier, Campion, Dominique, Renseigné, Non, Moreaud, Olivier
Publikováno v: European Journal of Human Genetics
European Journal of Human Genetics, 2012, 20 (6), pp.613-7. ⟨10.1038/ejhg.2011.225⟩
European Journal of Human Genetics, Nature Publishing Group, 2012, 20 (6), pp.613-7. ⟨10.1038/ejhg.2011.225⟩
International audience; Studying rare extreme forms of Alzheimer disease (AD) may prove to be a useful strategy in identifying new genes involved in monogenic determinism of AD. Amyloid precursor protein (APP), PSEN1, and PSEN2 mutations account for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35111f827bf244d21a1d010bdb701e69
https://hal.science/hal-00965208
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