A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy

Autor: Roberta Mazzone, Piero Picci, Katia Scotlandi, Michela Pasello, Patrizia Nanni, Giordano Nicoletti, Maria Cristina Manara, Antonello Mai, Clara Guerzoni, Camilla Cristalli, Pier Luigi Lollini, Lorena Landuzzi, Sergio Valente, Giulia Stazi, Paola B. Arimondo, Clemens Zwergel

Publikováno v: Molecular Cancer Therapeutics
Molecular Cancer Therapeutics, American Association for Cancer Research, 2018, 17 (9), pp.1881-1892. ⟨10.1158/1535-7163.MCT-17-0818⟩

The identification of new therapeutic strategies against osteosarcoma, the most common primary bone tumor, continues to be a primary goal to improve the outcomes of patients refractory to conventional chemotherapy. Osteosarcoma originates from the tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55d5482d55dc2ed43ad6818ec4cbf60
https://hal.archives-ouvertes.fr/hal-02383680

Imiquimod 5% cream for external genital or perianal warts in human immunodeficiency virus-positive patients treated with highly active antiretroviral therapy: an open-label, noncomparative study

Autor: Philippe Saiag, Christiane Mougin, F. Bouscarat, A. Bauhofer, C. Aquilina, J. P. Ortonne, Nicolas Dupin

Publikováno v: British Journal of Dermatology
British Journal of Dermatology, Wiley, 2009, 161 (4), pp.904-9. ⟨10.1111/j.1365-2133.2009.09210.x⟩
British Journal of Dermatology, Wiley, 2009, 161 (4), pp.904-9. 〈10.1111/j.1365-2133.2009.09210.x〉

Summary Background Human immunodeficiency virus (HIV)+ patients have an increased risk of anogenital warts. High-risk (HR) human papillomaviruses (HPVs), especially types 16 and 18, are major risk factors for precancerous and cancerous lesions of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6eeffe4e321943eb9d8f455b8fbe1e
https://pubmed.ncbi.nlm.nih.gov/19466962

The ferroquine antimalarial conundrum: redox activation and reinvasion inhibition

Autor: Christian Slomianny, Hadidjatou Kalamou, Daniel Dive, Philippe Grellier, Yann Guérardel, Faustine Dubar, Jamal Khalife, Christophe Biot

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2013, 52 (30), pp.7690-7693. ⟨10.1002/anie.201303690⟩
Angewandte Chemie International Edition, 2013, 52 (30), pp.7690-7693. ⟨10.1002/anie.201303690⟩

International audience; Metal health: Ferroquine is a ferrocene-based analogue of the antimalarial drug chloroquine. In addition to the primary mechanism of quinoline action, fluorescent probe studies in infected red blood cells show another mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7194aa0a005d869b60b500e40959405b
https://pubmed.ncbi.nlm.nih.gov/23765846

Polyaminoquinoline iron chelators for vectorization of antiproliferative agents: design, synthesis, and validation

Autor: David Deniaud, Sébastien G. Gouin, Raphaël Tripier, Solène Guihéneuf, Luís M. P. Lima, Karine Julienne, Eric Renault, Stéphanie Renaud, Emmanuelle Morin, Olivier Loréal, Vincent Corcé, François Gaboriau, Isabelle Cannie

Publikováno v: Bioconjugate Chemistry
Bioconjugate Chemistry, American Chemical Society, 2012, 23 (9), pp.1952-68. ⟨10.1021/bc300324c⟩
Bioconjugate Chemistry, 2012, 23 (9), pp.1952-68. ⟨10.1021/bc300324c⟩

International audience; Iron chelation in tumoral cells has been reported as potentially useful during antitumoral treatment. Our aim was to develop new polyaminoquinoline iron chelators targeting tumoral cells. For this purpose, we designed, synthes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ecbc8a59cb4f399c22aab193bba73f6
https://www.hal.inserm.fr/inserm-00863636

New developments on the galactopoietic role of prolactin in dairy ruminants

Autor: Frederic Dessauge, Pierre Lacasse, Vanessa Lollivier, S. Ollier, Rupert M. Bruckmaier, Marion Boutinaud

Publikováno v: 7. International Congress on Farm Animal Endocrinology (ICFAE), Bern, CHE, 2011-08-24-2011-08-26
7. International Congress on Farm Animal Endocrinology (ICFAE)
7. International Congress on Farm Animal Endocrinology (ICFAE), Aug 2011, Bern, Switzerland
Domestic Animal Endocrinology
7th International Conference on Farm Animal Endocrinology
Domestic Animal Endocrinology, Elsevier, 2012, 43 (2), pp.154-60. ⟨10.1016/j.domaniend.2011.12.007⟩

In most mammals, prolactin (PRL) is essential for maintaining lactation and its suppression strongly inhibits lactation. However, the involvement of PRL in the control of ruminant lactation is less clear because inconsistent effects on milk yield hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67c2a36a0ab0a45eb5807ada83c820f
http://prodinra.inra.fr/record/264845