Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting

Autor: Fran Robson, Palma Rocchi, Sinem Demirbag, Thi Khanh Le, Khadija Shahed Khan, Clément Paris, Peter Barfuss, Wai-Lung Ng

Publikováno v: Molecular Cell
Molecular Cell, Elsevier, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Molecular Cell, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩

Summary The coronavirus disease 2019 (COVID-19) that is wreaking havoc on global public health and economies has heightened awareness about the lack of effective antiviral treatments for human coronaviruses (CoVs). Many current antivirals, notably nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e7c3d34b3a0e2ab6d0db7eece5c7f1
https://pubmed.ncbi.nlm.nih.gov/33338403

Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes

Autor: Xavier Brazzolotto, Florian Nachon, Marko Živin, Jure Stojan, Maja Zorović, Damijan Knez, Jacques-Philippe Colletier, Urban Košak, Stanislav Gobec, Stane Pajk, Nicolas Coquelle

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35 (1), pp.498-505. ⟨10.1080/14756366.2019.1710502⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2020, 35 (1), pp.498-505. ⟨10.1080/14756366.2019.1710502⟩
Journal of enzyme inhibition and medicinal chemistry, vol. 35, no. 1, pp. 498-505, 2020.
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 498-505 (2020)

International audience; Brain butyrylcholinesterase (BChE) is an attractive target for drugs designed for the treatment of Alzheimer’s disease (AD) in its advanced stages. It also potentially represents a biomarker for progression of this disease.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346bbfead7d353e2e74735bc335c4593
https://hal.science/hal-03014299/file/Pajk2020.pdf

Natural noncanonical protein splicing yields products with diverse b-amino acid residues

Autor: Maximilian J. Helf, James Sims, Jörn Piel, Brandon I. Morinaka, Anna L. Vagstad, Muriel Gugger, Shinichi Sunagawa, Marjan Verest, Edgars Lakis, Thibault Scalvenzi

Publikováno v: Science
Science, 2018, 359 (6377), pp.779-782. ⟨10.1126/science.aao0157⟩
Science, American Association for the Advancement of Science, 2018, 359 (6377), pp.779-782. ⟨10.1126/science.aao0157⟩

Protein backbone, broken and mended Small, posttranslationally modified peptides are produced by microorganisms as antimicrobial agents or to communicate with neighboring cells. Alterations to the peptide backbone can change the structure of peptides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6a19830fe9433d8efaa92f9373eb42
https://hal-pasteur.archives-ouvertes.fr/pasteur-02044549

Favipiravir pharmacokinetics in Ebola-Infected patients of the JIKI trial reveals concentrations lower than targeted

Autor: Nguyen, Thi Huyen Tram, Guedj, Jérémie, Anglaret, Xavier, Laouénan, Cédric, Madelain, Vincent, Taburet, Anne-Marie, Baize, Sylvain, Sissoko, Daouda, Pastorino, Boris, Rodallec, Anne, Piorkowski, Géraldine, Carazo, Sara, Conde, Mamoudou N, Gala, Jean-Luc, Bore, Joseph Akoi, Carbonnelle, Caroline, Jacquot, Frédéric, Raoul, Hervé, Malvy, Denis, de Lamballerie, Xavier, Mentré, France, JIKI study group

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2017, 11 (2), pp.e0005389. ⟨10.1371/journal.pntd.0005389⟩
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005389 (2017)
PLOS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, 2017, 11 (2), pp.e0005389. ⟨10.1371/journal.pntd.0005389⟩
PLoS Neglected Tropical Diseases, Vol. 11, no.2, p. e0005389 [1-18] (2017)

Background In 2014–2015, we assessed favipiravir tolerance and efficacy in patients with Ebola virus (EBOV) disease (EVD) in Guinea (JIKI trial). Because the drug had never been used before for this indication and that high concentrations of the dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1051530eae51cb41207f0c146dd54e76
https://hal.archives-ouvertes.fr/hal-02309055

Polar actomyosin contractility destabilizes the position of the cytokinetic furrow

Autor: Maté Biro, Annelie Oswald, Guillaume Salbreux, Jakub Sedzinski, Ewa K. Paluch, Jean-Yves Tinevez

Publikováno v: Nature
Nature, Nature Publishing Group, 2011, 476 (7361), pp.462-466. ⟨10.1038/nature10286⟩

Studies of the mechanism of cytokinesis, the process by which a mother cell undergoes cleavage to form two separated daughter cells, often focus on the action of the contractile actomyosin ring at the cell equator. Ewa Paluch and colleagues instead i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c082b86ec2f93524d871f810b1eecb36
https://doi.org/10.1038/nature10286