Zobrazeno 1 - 10
of 23
pro vyhledávání: '"MESH: Allosteric Site"'
Autor:
Marisa M. Fernández, Felipe Trajtenberg, Hugo Gramajo, Lautaro Diacovich, Nicole Larrieux, Gabriela Gago, Julia Lara, Emilio L. Malchiodi, Alejandro Buschiazzo
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.3703. ⟨10.1038/s41467-020-17504-x⟩
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications, 2020, 11 (1), pp.3703. ⟨10.1038/s41467-020-17504-x⟩
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.3703. ⟨10.1038/s41467-020-17504-x⟩
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications, 2020, 11 (1), pp.3703. ⟨10.1038/s41467-020-17504-x⟩
Mycobacterium tuberculosis is a pathogen with a unique cell envelope including very long fatty acids, implicated in bacterial resistance and host immune modulation. FasR is a TetR-like transcriptional activator that plays a central role in sensing my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0c9ff504288d18e5194304c77d818d
https://hal-pasteur.archives-ouvertes.fr/pasteur-03246643/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-03246643/document
Publikováno v:
Structure
Structure, Elsevier (Cell Press), 2021, 29 (4), pp.371-384.e3. ⟨10.1016/j.str.2020.11.015⟩
Structure, Elsevier (Cell Press), 2021, 29 (4), pp.371-384.e3. ⟨10.1016/j.str.2020.11.015⟩
Proteins are known to undergo structural changes upon binding to partner proteins. However, the prevalence, extent, location, and function of change in protein dynamics due to transient protein-protein interactions is not well documented. Here, we ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf16d0a5f884b5bcd9ff0a578b2e7b6
https://pubmed.ncbi.nlm.nih.gov/33306961
https://pubmed.ncbi.nlm.nih.gov/33306961
Autor:
Canul-Tec, Juan, Assal, Reda, Cirri, Erica, Legrand, Pierre, Brier, Sébastien, Chamot-Rooke, Julia, Reyes, Nicolas
Publikováno v:
Nature
Nature, Nature Publishing Group, 2017, 544 (7651), pp.446-451. ⟨10.1038/nature22064⟩
Nature, Nature Publishing Group, 2017, 544 (7651), pp.446-451. 〈10.1038/nature22064〉
Nature, 2017, 544 (7651), pp.446-451. ⟨10.1038/nature22064⟩
Nature, Nature Publishing Group, 2017, 544 (7651), pp.446-451. ⟨10.1038/nature22064⟩
Nature, Nature Publishing Group, 2017, 544 (7651), pp.446-451. 〈10.1038/nature22064〉
Nature, 2017, 544 (7651), pp.446-451. ⟨10.1038/nature22064⟩
International audience; Human members of the solute carrier 1 (SLC1) family of transporters take up excitatory neurotransmitters in the brain and amino acids in peripheral organs. Dysregulation of the function of SLC1 transporters is associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::35cff77c634037361ae6a5795e16f512
https://hal-pasteur.archives-ouvertes.fr/pasteur-01655604/file/Canul-Tech-etal_nature_accepted_HAL.pdf
https://hal-pasteur.archives-ouvertes.fr/pasteur-01655604/file/Canul-Tech-etal_nature_accepted_HAL.pdf
Autor:
Karine Barral, Françoise Debart, Baptiste Martin, Bruno Canard, Jean-Jacques Vasseur, Etienne Decroly, Bruno Coutard, Wahiba Aouadi, Barbara Selisko, Miguel Ortiz Lombardia, Julie Lichière, Jean-Claude Guillemot
Publikováno v:
Journal of Virology
Journal of Virology, American Society for Microbiology, 2017, 91 (5), pp.2202-2218. ⟨10.1128/JVI.02202-16⟩
Journal of Virology, 2017, 91 (5), pp.2202-2218. ⟨10.1128/JVI.02202-16⟩
Journal of Virology, American Society for Microbiology, 2017, 91 (5), pp.2202-2218. 〈10.1128/JVI.02202-16〉
Journal of Virology, American Society for Microbiology, 2017, 91 (5), pp.2202-2218. ⟨10.1128/JVI.02202-16⟩
Journal of Virology, 2017, 91 (5), pp.2202-2218. ⟨10.1128/JVI.02202-16⟩
Journal of Virology, American Society for Microbiology, 2017, 91 (5), pp.2202-2218. 〈10.1128/JVI.02202-16〉
The Flavivirus Zika virus (ZIKV) is the causal agent of neurological disorders like microcephaly in newborns or Guillain-Barre syndrome. Its NS5 protein embeds a methyltransferase (MTase) domain involved in the formation of the viral mRNA cap. We inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffe7250f26c460bd101303c39f3c32f
https://hal.archives-ouvertes.fr/hal-01802793
https://hal.archives-ouvertes.fr/hal-01802793
Autor:
Ricardo M. Biondi, Sonja Neimanis, Katrien Busschots, Pedro M. Alzari, Jörg O. Schulze, Evelyn Süß, Giorgio Saladino, Dalibor Odadzic, María-Natalia Lisa, Francesco Luigi Gervasio, Stefan Zeuzem, V. Hindie, Amanda K. Herbrand
Publikováno v:
Cell Chemical Biology
Cell Chemical Biology, 2016, 23 (10), pp.1193-1205. ⟨10.1016/j.chembiol.2016.06.017⟩
Cell Chemical Biology, Cell Press, 2016, 23 (10), pp.1193-1205. ⟨10.1016/j.chembiol.2016.06.017⟩
Cell Chemical Biology, 2016, 23 (10), pp.1193-1205. ⟨10.1016/j.chembiol.2016.06.017⟩
Cell Chemical Biology, Cell Press, 2016, 23 (10), pp.1193-1205. ⟨10.1016/j.chembiol.2016.06.017⟩
Allostery is a phenomenon observed in many proteins where binding of a macromolecular partner or a small-molecule ligand at one location leads to specific perturbations at a site not in direct contact with the region where the binding occurs. The lis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d867b386e72af28a9d576ede95d57628
https://doi.org/10.1016/j.chembiol.2016.06.017
https://doi.org/10.1016/j.chembiol.2016.06.017
Autor:
Maurizio Brunori
Publikováno v:
FEBS Journal
FEBS Journal, Wiley, 2014, 281 (2), pp.633-43. ⟨10.1111/febs.12586⟩
FEBS Journal, Wiley, 2014, 281 (2), pp.633-43. ⟨10.1111/febs.12586⟩
International audience; Conformational selection between pre-existing structural states of an oligomeric protein was the conceptual step behind the formulation of Monod-Wyman-Changeux (MWC) allosteric theory. Variations on the basic theme of alloster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b95a36b1f876057032f1b26dcdcb04
https://doi.org/10.1111/febs.12586
https://doi.org/10.1111/febs.12586
Publikováno v:
Toxins
Toxins, MDPI, 2012, 4, pp.580-604. ⟨10.3390/toxins4080580⟩
Toxins, 2012, 4, pp.580-604. ⟨10.3390/toxins4080580⟩
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Toxins, Vol 4, Iss 8, Pp 580-604 (2012)
Toxins, MDPI, 2012, 4, pp.580-604. ⟨10.3390/toxins4080580⟩
Toxins, 2012, 4, pp.580-604. ⟨10.3390/toxins4080580⟩
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Toxins, Vol 4, Iss 8, Pp 580-604 (2012)
Edema Factor (EF) is a component of Bacillus anthracis toxin essential for virulence. Its adenylyl cyclase activity is induced by complexation with the ubiquitous eukaryotic cellular protein, calmodulin (CaM). EF and its complexes with CaM, nucleotid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798e5309ad70887a9a481e9683f25c81
https://doi.org/10.3390/toxins4080580
https://doi.org/10.3390/toxins4080580
Autor:
Leila Idrissova, Thomas J. D. Jørgensen, Adriana Stroba, V. Hindie, Pedro M. Alzari, Stefan Zeuzem, Francis Schaeffer, Hua Zhang, Daniel Hirschberg, Ricardo M. Biondi, Laura A. Lopez-Garcia, Matthias Engel
Publikováno v:
Nature Chemical Biology
Nature Chemical Biology, 2009, 5 (10), pp.758-764. ⟨10.1038/nchembio.208⟩
Nature Chemical Biology, Nature Publishing Group, 2009, 5 (10), pp.758-764. ⟨10.1038/nchembio.208⟩
Hindie, V, Stroba, A, Zhang, H, Lopez-Garcia, L A, Idrissova, L, Zeuzem, S, Hirschberg, D, Schaeffer, F, Jørgensen, T J D, Engel, M, Alzari, P M & Biondi, R M 2009, ' Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1 ', Nature Chemical Biology, vol. 5, no. 10, pp. 758-764 . https://doi.org/10.1038/nchembio.208
Nature Chemical Biology, 2009, 5 (10), pp.758-764. ⟨10.1038/nchembio.208⟩
Nature Chemical Biology, Nature Publishing Group, 2009, 5 (10), pp.758-764. ⟨10.1038/nchembio.208⟩
Hindie, V, Stroba, A, Zhang, H, Lopez-Garcia, L A, Idrissova, L, Zeuzem, S, Hirschberg, D, Schaeffer, F, Jørgensen, T J D, Engel, M, Alzari, P M & Biondi, R M 2009, ' Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1 ', Nature Chemical Biology, vol. 5, no. 10, pp. 758-764 . https://doi.org/10.1038/nchembio.208
Udgivelsesdato: 2009-Oct Protein phosphorylation transduces a large set of intracellular signals. One mechanism by which phosphorylation mediates signal transduction is by prompting conformational changes in the target protein or interacting proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d943026894f821cd75f045591aae94a0
https://doi.org/10.1038/nchembio.208
https://doi.org/10.1038/nchembio.208
Publikováno v:
Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2008, 73 (3), pp.909-18. ⟨10.1124/mol.107.040097⟩
Molecular Pharmacology, 2008, 73 (3), pp.909-18. ⟨10.1124/mol.107.040097⟩
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2008, 73 (3), pp.909-18. ⟨10.1124/mol.107.040097⟩
Molecular Pharmacology, 2008, 73 (3), pp.909-18. ⟨10.1124/mol.107.040097⟩
International audience; Recent studies suggest that a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor (mGluRs), mGluR5, termed 4-nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (VU-29), potentiates mGluR5 responses by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47059f059a714b59bb5b600ea950f69a
https://doi.org/10.1124/mol.107.040097
https://doi.org/10.1124/mol.107.040097
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279 (8), pp.6354-63. ⟨10.1074/jbc.M311272200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279 (8), pp.6354-6363. ⟨10.1074/jbc.M311272200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279 (8), pp.6354-63. ⟨10.1074/jbc.M311272200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279 (8), pp.6354-6363. ⟨10.1074/jbc.M311272200⟩
International audience; The RecQ helicase family is highly conserved from bacteria to men and plays a conserved role in the preservation of genome integrity. Its deficiency in human cells leads to a marked genomic instability that is associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384ff4dac547d561a575aeff571635e4
https://doi.org/10.1074/jbc.m311272200
https://doi.org/10.1074/jbc.m311272200