Baclofen for alcohol dependence: relationships between baclofen and alcohol dosing and the occurrence of major sedation

Autor: Benjamin Rolland, Marine Auffret, Baptiste Pignon, Thomas Valin, Sylvie Deheul, Julien Labreuche, Olivier Cottencin, Sophie Gautier, Régis Bordet, Alain Duhamel

Publikováno v: European Neuropsychopharmacology
European Neuropsychopharmacology, Elsevier, 2015, European neuropsychopharmacology the journal of the European College of Neuropsychopharmacology, 25, pp.1631-1636. ⟨10.1016/j.euroneuro.2015.05.008⟩
European Neuropsychopharmacology, 2015, European neuropsychopharmacology the journal of the European College of Neuropsychopharmacology, 25, pp.1631-1636. ⟨10.1016/j.euroneuro.2015.05.008⟩

International audience; High-dose baclofen, i.e., 300 mg/d or more, has recently emerged as a strategy for treating alcohol dependence. The impact that the co-exposure of large amounts of alcohol and baclofen has on sedation is unclear. In a prospect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187a0d38561b81dc6adaae0ae63d5e8a
https://hal.univ-lille.fr/hal-02383815

Experimental findings in the study of the reduction of alcohol intake

Autor: Saloua Hammoumi, Mickaël Naassila, Martine Daoust

Publikováno v: European Neuropsychopharmacology
European Neuropsychopharmacology, Elsevier, 1997, 7 Suppl 3, pp.S337-40

International audience; Alcohol dependence represents a major problem in public health and different animal models of dependence have been developed in rodents with the aim of studying the mechanisms of alcohol abuse. Different ways of animal alcohol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a6cacef600c56fb2c87cd3b4120476
https://doi.org/10.1016/s0924-977x(97)00066-7

Biphasic effect of acamprosate on NMDA but not on GABAA receptors in spontaneous rhythmic activity from the isolated neonatal rat respiratory network

Autor: Olivier Pierrefiche, Mickaël Naassila, Martine Daoust

Publikováno v: Neuropharmacology
Neuropharmacology, Elsevier, 2004, 47 (1), pp.35-45. ⟨10.1016/j.neuropharm.2004.03.004⟩
Neuropharmacology, 2004, 47 (1), pp.35-45. ⟨10.1016/j.neuropharm.2004.03.004⟩

International audience; Acamprosate (calcium acetylhomotaurinate) has been shown to be effective in attenuating relapse in human alcoholics. The precise mechanism for acamprosate has been yet to be determined as there may be multiple sites of action

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82db807503e03db8e1145a4d76eb4522
https://www.hal.inserm.fr/inserm-00746176