Defining the genetic and evolutionary architecture of alternative splicing in response to infection

Autor: Lluis Quintana-Murci, Hélène Quach, Maxime Rotival

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.1671. ⟨10.1038/s41467-019-09689-7⟩
Nature Communications, 2019, 10 (1), pp.1671. ⟨10.1038/s41467-019-09689-7⟩
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Host and environmental factors contribute to variation in human immune responses, yet the genetic and evolutionary drivers of alternative splicing in response to infection remain largely uncharacterised. Leveraging 970 RNA-sequencing profiles of rest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1eb6390abe878f44d1931e6ad846777
https://hal-pasteur.archives-ouvertes.fr/pasteur-02549071

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Autor: Michael R. Brown, Christian Gieger, André G. Uitterlinden, Diana van Heemst, Alison D. Murray, Stephen B. Kritchevsky, Timo A. Lakka, Karen Schwander, Federica Laguzzi, Stephen S. Rich, Rajkumar Dorajoo, Yun Ju Sung, Xiaofeng Zhu, Hugues Aschard, Jing Hua Zhao, Gregory P. Wilson, Kenneth Rice, Barbara Sternfeld, Kent D. Taylor, Paul Elliott, Ei-Ei Khaing Nang, Ilja M. Nolte, Heather M. Stringham, Bruce M. Psaty, Heming Wang, Tangchun Wu, Caroline Hayward, Vilmundur Gudnason, Fernando Pires Hartwig, Paolo Gasparini, Jingjing Liang, Neil Risch, Albertine J. Oldehinkel, Ani Manichaikul, Tibor V. Varga, Michael Y. Tsai, Niek Verweij, Xueling Sim, Norihiro Kato, Evangelos Evangelou, Philippe Froguel, Xiuqing Guo, Traci M. Bartz, Nicholette D. Palmer, Woon-Puay Koh, Rozenn N. Lemaitre, Caizheng Yu, Mike A. Nalls, Mariaelisa Graff, Eric Boerwinkle, Dabeeru C. Rao, Thomas Meitinger, Virginia Fisher, Mario Sims, Charles Kooperberg, Carl D. Langefeld, Jaakko Tuomilehto, Reedik Mägi, Wei Zhao, Wanqing Wen, Donna K. Arnett, Ervin R. Fox, Lynda M. Rose, Maris Alver, Ayse Demirkan, Solomon K. Musani, Dennis O. Mook-Kanamori, Andres Metspalu, Jerome I. Rotter, Barry I. Freedman, Jiang He, Hermina Jakupović, Steven C. Hunt, Marco Brumat, Maria Pina Concas, Rob M. van Dam, Rico Rueedi, Jonathan Marten, Chi Charles Gu, Tõnu Esko, Peter Vollenweider, Zoltán Kutalik, Olli T. Raitakari, Ya X. Wang, Yong-Bing Xiang, Pamela J. Schreiner, Antonietta Robino, Tanika N. Kelly, Igor Rudan, Mathilde Boissel, Claudia Langenberg, Yii-Der Ida Chen, Anne U. Jackson, Lawrence F. Bielak, Brenda W.J.H. Penninx, Brigitte Kühnel, Christopher P. Nelson, Konstantin Strauch, Albert V. Smith, Daniel I. Chasman, Jasmin Divers, Lisa R. Yanek, M. Arfan Ikram, Melissa A. Richard, Nilesh J. Samani, Lisa de las Fuentes, H. Janaka de Silva, Jana V. van Vliet-Ostaptchouk, Yongmei Liu, Peter J. van der Most, Fang-Chi Hsu, Jeffrey R. O'Connell, Alexandre C. Pereira, Raymond Noordam, Changwei Li, Jie Yao, Trudy Voortman, Zhe Wang, Thomas H. Mosley, Diane M. Becker, Charles N. Rotimi, Sami Heikkinen, Archie Campbell, John M. C. Connell, Lenore J. Launer, Hua Tang, Rainer Rauramaa, Ruth J. F. Loos, Pirjo Komulainen, Amy R. Bentley, Patrik Wennberg, Chew-Kiat Heng, Kari E. North, Salman M. Tajuddin, Renée de Mutsert, David J. Porteous, Susan Redline, Sarah E. Harris, Tamara B. Harris, Raha Pazoki, Mickaël Canouil, Robert A. Scott, Jingzhong Ding, Mary F. Feitosa, Jost B. Jonas, José Eduardo Krieger, John M. Starr, Karin Leander, Jennifer A. Smith, Paul W. Franks, Charles B. Eaton, Sharon L.R. Kardia, E. Shyong Tai, Jill M. Norris, Annette Peters, Chiamaka Vivian Nwuba, Jianjun Liu, Stella Aslibekyan, Nora Franceschini, Kurt Lohman, Myriam Fornage, Dina Vojinovic, Erin B. Ware, Xiaoyin Li, Najaf Amin, Johanna Kuusisto, M. Yldau van der Ende, Cora E. Lewis, Lynne E. Wagenknecht, Jennifer G. Robinson, Franco Giulianini, Ulf de Faire, Yechiel Friedlander, Nicholas J. Wareham, Meian He, George J. Papanicolau, Nancy L. Pedersen, Bernardo L. Horta, Karen L. Mohlke, Kelley Pettee Gabriel, Minjung Kho, Michele K. Evans, Ozren Polasek, Markku Laakso, Tuomas O. Kilpeläinen, Ching-Ti Liu, Michael Boehnke, Jin-Fang Chai, Ioanna Ntalla, Cornelia M. van Duijn, L. Adrienne Cupples, Yuri Milaneschi, Stephen Sidney, Alan B. Zonderman, Leo-Pekka Lyytikäinen, Mohsen Ghanbari, Harold Snieder, Donald W. Bowden, Aldi T. Kraja, Alaitz Poveda, Terho Lehtimäki, Paul S. de Vries, Dongfeng Gu, Sotoodehnia Nona, Thomas W. Winkler, Muhammad Riaz, Ian J. Deary, Fumihiko Takeuchi, Pim van der Harst, Alisa K. Manning, Michael A. Province, Andrea R. V. R. Horimoto, David R. Weir, Wei Zheng, Alanna C. Morrison, Marzyeh Amini, Jian-Min Yuan, W. James Gauderman, Paul M. Ridker, Melanie Waldenberger, Chuan Gao, Xiao-Ou Shu, Patricia B. Munroe, Patricia A. Peyser, Jessica D. Faul, Xu Chen, Brian E. Cade, Patrik K. E. Magnusson, Tamar Sofer

Publikováno v: Nature Communications, 10(1):376. Nature Publishing Group
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.376. ⟨10.1038/s41467-018-08008-w⟩
Kilpeläinen, T O, Bentley, A R & Loos, R J F 2019, ' Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity ', Nature Communications, vol. 10, no. 1, 376 . https://doi.org/10.1038/s41467-018-08008-w
Kilpeläinen, T O, Bentley, A R, Noordam, R, Sung, Y J, Schwander, K, Winkler, T W, Jakupović, H, Chasman, D I, Manning, A, Ntalla, I, Aschard, H, Brown, M R, de las Fuentes, L, Franceschini, N, Guo, X, Vojinovic, D, Aslibekyan, S, Feitosa, M F, Kho, M, Musani, S K, Richard, M, Wang, H, Wang, Z, Bartz, T M, Bielak, L F, Campbell, A, Dorajoo, R, Fisher, V, Hartwig, F P, Horimoto, A R V R, Li, C, Lohman, K K, Marten, J, Sim, X, Smith, A V, Tajuddin, S M, Alver, M, Amini, M, Boissel, M, Chai, J F, Chen, X, Divers, J, Evangelou, E, Gao, C, Graff, M, Harris, S E, He, M, Hsu, F C, Zhao, J H, Loos, R J F, LifeLines Cohort Study & V Varga, T 2019, ' Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity ', Nature Communications, vol. 10, 376 . https://doi.org/10.1038/s41467-018-08008-w
Kilpeläinen, T O, Bentley, A R, Noordam, R, Sung, Y J, Schwander, K, Winkler, T W, Jakupović, H, Chasman, D I, Manning, A, Ntalla, I, Aschard, H, Brown, M R, de las Fuentes, L, Franceschini, N, Guo, X, Vojinovic, D, Aslibekyan, S, Feitosa, M F, Kho, M, Musani, S K, Richard, M, Wang, H, Wang, Z, Bartz, T M, Bielak, L F, Campbell, A, Dorajoo, R, Fisher, V, Hartwig, F P, Horimoto, A R V R, Li, C, Lohman, K K, Marten, J, Sim, X, Smith, A V, Tajuddin, S M, Alver, M, Amini, M, Boissel, M, Chai, J F, Chen, X, Divers, J, Evangelou, E, Gao, C, Graff, M, Harris, S E, He, M, Milaneschi, Y, Yuan, J-M, Penninx, B W J H, Lifelines Cohort Study, Weir, D R, Franks, P W, Rotter, J I, Kooperberg, C B, Gauderman, W J, Psaty, B M, Rice, K M, Munroe, P B, Fornage, M, Cupples, L A, Rotimi, C N, Morrison, A C, Rao, D C & Loos, R J F 2019, ' Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity ', Nature Communications, vol. 10, no. 1, 376 . https://doi.org/10.1038/s41467-018-08008-w
Nature Communications, 10
Nature Communications, 10:376. Nature Publishing Group
Nature Communications, 2019, 10 (1), pp.376. ⟨10.1038/s41467-018-08008-w⟩
Nat. Commun. 10:376 (2019)
Nature communications, vol. 10, no. 1, pp. 376

Publisher's version (útgefin grein)
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0762057e28a365b8dbed4f0bf77d1b25
http://hdl.handle.net/10044/1/66702

Food Consumption, Knowledge, Attitudes, and Practices Related to Salt in Urban Areas in Five Sub-Saharan African Countries

Autor: Pascal Bovet, Carmelle Mizéhoun-Adissoda, Bharathi Viswanathan, Naby Balde, Magali Leyvraz, Dismand Houinato, Arnaud Chiolero, Mary Amyunzu-Nyamongo, J.O. Owuor, Albertino Damasceno

Publikováno v: Nutrients
Nutrients, MDPI, 2018, 10 (8), pp.1028. ⟨10.3390/nu10081028⟩
Leyvraz, Magali; Mizéhoun-Adissoda, Carmelle; Houinato, Dismand; Moussa Baldé, Naby; Damasceno, Albertino; Viswanathan, Bharathi; Amyunzu-Nyamongo, Mary; Owuor, Jared; Chiolero, Arnaud; Bovet, Pascal (2018). Food Consumption, Knowledge, Attitudes, and Practices Related to Salt in Urban Areas in Five Sub-Saharan African Countries. Nutrients, 10(8), E1028. Molecular Diversity Preservation International MDPI 10.3390/nu10081028
Nutrients, vol. 10, no. 8, pp. E1028
Volume 10
Issue 8
Nutrients, Vol 10, Iss 8, p 1028 (2018)

International audience; High salt intake is a major risk factor of hypertension and cardiovascular disease. Improving knowledge, attitudes, and practices (KAP) related to salt intake in the general population is a key component of salt reduction stra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be72edda8457bd1f2fc740f031edf98b
https://hal-unilim.archives-ouvertes.fr/hal-02048150

An ancestry-based approach for detecting interactions

Autor: Noah Zaitlen, Hugues Aschard, Christopher R. Gignoux, Celeste Eng, Eun Yong Kang, Danny S. Park, Eric R. Gamazon, Esteban G. Burchard, Chun Jimmie Ye, Joshua Galanter, Itamar Eskin, Eran Halperin, Eleazar Eskin

Publikováno v: Genetic epidemiology, vol 42, iss 1
Genetic Epidemiology
Genetic Epidemiology, Wiley, 2018, 42 (1), pp.49-63. ⟨10.1002/gepi.22087⟩
Genetic epidemiology, 42(1), 49-63. Wiley-Liss Inc.

International audience; Background: Epistasis and gene-environment interactions are known to contribute significantly to variation of complex phenotypes in model organisms. However, their identification in human association studies remains challengin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7299172b967c7c5f6cdc33196441968
https://escholarship.org/uc/item/7kc0k081

The Genetic Legacy of the Indian Ocean Slave Trade: Recent Admixture and Post-admixture Selection in the Makranis of Pakistan

Autor: Lluis Quintana-Murci, Chris Tyler-Smith, Qasim Ayub, Christine Harmant, Nora Zidane, Etienne Patin, Hélène Quach, Qasim Syed Mehdi, Romuald Laso-Jadart

Publikováno v: American Journal of Human Genetics
American Journal of Human Genetics, 2017, 101 (6), pp.977-984. ⟨10.1016/j.ajhg.2017.09.025⟩
American Journal of Human Genetics, Elsevier (Cell Press), 2017, 101 (6), pp.977-984. ⟨10.1016/j.ajhg.2017.09.025⟩

International audience; From the eighth century onward, the Indian Ocean was the scene of extensive trade of sub-Saharan African slaves via sea routes controlled by Muslim Arab and Swahili traders. Several populations in present-day Pakistan and Indi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1571b4a38ac27233bf831f8be15c947
https://hal.science/hal-02352837