Zobrazeno 1 - 10
of 143
pro vyhledávání: '"MESH: Adaptor Proteins, Signal Transducing"'
Autor:
Gagnoux-Palacios, Laurent, Awina, Hala, Audebert, Stéphane, Rossin, Aurélie, Mondin, Magali, Borgese, Franck, Planas-Botey, Carlota, Mettouchi, Amel, Borg, Jean-Paul, Hueber, Anne-Odile
Publikováno v:
Journal of Cell Biology
Journal of Cell Biology, 2018, 217 (11), pp.3839-3852. ⟨10.1083/jcb.201805071⟩
The Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2018, 217 (11), pp.3839-3852. ⟨10.1083/jcb.201805071⟩
Journal of Cell Biology, 2018, 217 (11), pp.3839-3852. ⟨10.1083/jcb.201805071⟩
The Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2018, 217 (11), pp.3839-3852. ⟨10.1083/jcb.201805071⟩
Control of epithelial cell death is crucial to maintaining tissue integrity. Gagnoux-Palacios et al. show that cell polarity and adherens junction formation prevent proapoptotic signals emanating from the Fas death receptor. Therefore, Fas-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5b791786ff71a152338fb2a61cdb54f7
https://hal.science/hal-02374965/document
https://hal.science/hal-02374965/document
Autor:
Maxime Chazal, Sarah Lesage, Takashi Fujita, Ségolène Gracias, Eliane F. Meurs, Laura Sinigaglia, Frédéric Tangy, Daniela Bruni, Felix Streicher, Guillaume Beauclair, Salomé Bourgeau, Nolwenn Jouvenet
Publikováno v:
J Virol
Journal of Virology
Journal of Virology, 2020, 94 (22), pp.e00403-20. ⟨10.1128/JVI.00403-20⟩
Journal of Virology, American Society for Microbiology, 2020, 94 (22), pp.e00403-20. ⟨10.1128/JVI.00403-20⟩
Journal of Virology
Journal of Virology, 2020, 94 (22), pp.e00403-20. ⟨10.1128/JVI.00403-20⟩
Journal of Virology, American Society for Microbiology, 2020, 94 (22), pp.e00403-20. ⟨10.1128/JVI.00403-20⟩
International audience; Yellow fever virus (YFV) is an RNA virus primarily targeting the liver. Severe YF cases are responsible for hemorrhagic fever, plausibly precipitated by excessive proinflammatory cytokine response. Pathogen recognition recepto
Autor:
Manfred Jung, Karin Schmidtkunz, Elizabeth R Morales, Stefan Günther, Wolfgang Sippl, Martin Hügle, Frank Erdmann, Patrik Zeyen, Ehab Ghazy, Dina Robaa, Christophe Romier, Matthias Schmidt, Daniel Herp
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2020, 200, pp.112338. ⟨10.1016/j.ejmech.2020.112338⟩
European Journal of Medicinal Chemistry, Elsevier, 2020, 200, pp.112338. ⟨10.1016/j.ejmech.2020.112338⟩
European Journal of Medicinal Chemistry, 2020, 200, pp.112338. ⟨10.1016/j.ejmech.2020.112338⟩
European Journal of Medicinal Chemistry, Elsevier, 2020, 200, pp.112338. ⟨10.1016/j.ejmech.2020.112338⟩
International audience; Histone modifying proteins, specifically histone deacetylases (HDACs) and bromodomains, have emerged as novel promising targets for anticancer therapy. In the current work, based on available crystal structures and docking stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738621ff6d5b1624d9660f91e10c4ab7
https://hal.science/hal-02999300/document
https://hal.science/hal-02999300/document
Autor:
Cécile Aubert, Maithé Tauber, Ronan Roussel, Bénédicte Toussaint, François Pattou, Philippe Froguel, Jean-Michel Borys, Amjad Ghulam, Hélène Loiselle, Mathilde Boissel, Emmanuelle Durand, Sylvia Franc, Julie Kerr-Conte, Julie Maillet, Morgane Baron, Marlène Huyvaert, Amélie Bonnefond, Raphaël Boutry, J. Philippe, Jérémy Thomas, Guillaume Charpentier, Claire Lévy-Marchal, Michel Marre, Mehdi Derhourhi, Aurélie Dechaume, Emmanuel Vaillant, B. Balkau, Stefan Gaget, Raphael Scharfmann, Jacques Weill, Mickaël Canouil
Publikováno v:
Nature Medicine
Nature Medicine, 2019, 25 (11), pp.1733-1738. ⟨10.1038/s41591-019-0622-0⟩
Nature medicine
Nature Medicine, Nature Publishing Group, 2019, 25 (11), pp.1733-1738. ⟨10.1038/s41591-019-0622-0⟩
Nature Medicine, 2019, 25 (11), pp.1733-1738. ⟨10.1038/s41591-019-0622-0⟩
Nature medicine
Nature Medicine, Nature Publishing Group, 2019, 25 (11), pp.1733-1738. ⟨10.1038/s41591-019-0622-0⟩
International audience; The G-protein-coupled receptor accessory protein MRAP2 is implicated in energy control in rodents, notably via the melanocortin-4 receptor1. Although some MRAP2 mutations have been described in people with obesity1-3, their fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e4070864d7e526bb4fbf52762499c4
https://www.hal.inserm.fr/inserm-02439220/document
https://www.hal.inserm.fr/inserm-02439220/document
Autor:
Hamon, Annaïg, Masson, Christel, Bitard, Juliette, Gieser, Linn, Roger, Jérôme E., Perron, Muriel
Publikováno v:
Investigative Ophthalmology & Visual Science
Investigative Ophthalmology & Visual Science, Association for Research in Vision and Ophthalmology, 2017, 58 (4), pp.1941-1953. ⟨10.1167/iovs.16-21366⟩
Investigative Ophthalmology & Visual Science, Association for Research in Vision and Ophthalmology, 2017, 58 (4), pp.1941-1953. ⟨10.1167/iovs.16-21366⟩
Purpose During retinal degeneration, Müller glia cells respond to photoreceptor loss by undergoing reactive gliosis, with both detrimental and beneficial effects. Increasing our knowledge of the complex molecular response of Müller cells to retinal
Autor:
Marta Mastrogiovanni, Paola Grazioli, Antonio Francesco Campese, Loretta Tuosto, Balbino Alarcón, Silvana Caristi, Cédric Favre, Nicla Porciello, Francesca Spadaro, Jacques A. Nunès, Isabella Screpanti, Martina Kunkl, Michela Muscolini, Aldo Borroto
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.1080. ⟨10.1038/s41467-018-03385-8⟩
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications, 2018, 9 (1), pp.1080. ⟨10.1038/s41467-018-03385-8⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.1080. ⟨10.1038/s41467-018-03385-8⟩
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications, 2018, 9 (1), pp.1080. ⟨10.1038/s41467-018-03385-8⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
CD28 superagonistic antibodies (CD28SAb) can preferentially activate and expand immunosuppressive regulatory T cells (Treg) in mice. However, pre-clinical trials assessing CD28SAbs for the therapy of autoimmune diseases reveal severe systemic inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29edf0332e8787c555c9b6ff4b29196e
https://hal.archives-ouvertes.fr/hal-01772994
https://hal.archives-ouvertes.fr/hal-01772994
Autor:
Isabelle Landrieu, François-Xavier Cantrelle, Yoann Sottejeau, Guy Lippens, Idir Malki, Jean-Charles Lambert
Publikováno v:
FEBS Journal
FEBS Journal, 2017, 284 (19), pp.3218-3229. ⟨10.1111/febs.14185⟩
FEBS Journal, Wiley, 2017, 284 (19), pp.3218-3229. ⟨10.1111/febs.14185⟩
FEBS Journal, 2017, 284 (19), pp.3218-3229. ⟨10.1111/febs.14185⟩
FEBS Journal, Wiley, 2017, 284 (19), pp.3218-3229. ⟨10.1111/febs.14185⟩
International audience; Bridging integrator 1 (bin1) gene is a genetic determinant of Alzheimer's disease (AD) and has been reported to modulate Alzheimer's pathogenesis through pathway(s) involving Tau. The functional impact of Tau/BIN1 interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe112535792d7f053c980ddc7146484
https://hal.science/hal-01620146
https://hal.science/hal-01620146
Autor:
Elsa Kress, Mathias Heikenwalder, Gerard Lina, David Bauché, Saskia Lippens, Claire Macari, Marie-Cécile Michallet, Mathias Chamaillard, Sophia Djebali, Emilie Plantamura, Lyvia Moudombi, Jacqueline Marvel, Christophe Caux, Julien C. Marie, Annabelle Cesaro, Lilia Boucinha, Amiran Dzutsev, Jean-Philippe Rasigade, Ulrike Rothermel, Giorgio Trinchieri, Azzak Bentaher-Belaaouaj, Oana Dumitrescu, Morgan Grau, Michelina Plateroti, Clovis Bondu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (41), pp.10404-10409. ⟨10.1073/pnas.1722372115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (41), pp.10404-10409. ⟨10.1073/pnas.1722372115⟩
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (41), pp.10404-10409. ⟨10.1073/pnas.1722372115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (41), pp.10404-10409. ⟨10.1073/pnas.1722372115⟩
International audience; Prominent changes in the gut microbiota (referred to as "dysbiosis") play a key role in the development of allergic disorders, but the underlying mechanisms remain unknown. Study of the delayed-type hypersensitivity (DTH) resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f72c638beb7102ea94a7542c3c80f63
https://hal.science/hal-02398995
https://hal.science/hal-02398995
Autor:
Carine Bonnard, Mohamed Denguezli, Ali Saad, François Malecaze, John E. Connolly, Seth L. Masters, Hazel Tye, Moez Gribaa, John A. McGrath, Kim S. Robinson, Ons Mamaï, Vincent Soler, Aristotle Lau, Reshmaa Balaji, Ildikó Szeverényi, Atsushi Otsuka, Masashi Akiyama, Pierre Fournié, Richard Hopkins, Keya Roy, Patricia J. Ahl, Sebastian Hiller, Lorenzo Sborgi, Lobna Boussofara, L. A. Jones, Roxana Ioana Nedelcu, Kenji Kabashima, Salma Samir Omar, Takuya Takeichi, E. Birgitte Lane, Franklin L. Zhong, Paul J. Baker, Bruno Reversade, Lukáš Lacina
Publikováno v:
Cell
Cell, Elsevier, 2016, 167 (1), pp.187-202.e17. ⟨10.1016/j.cell.2016.09.001⟩
Cell, 167(1), 187-+. Cell Press
Cell, 2016, 167 (1), pp.187-202.e17. ⟨10.1016/j.cell.2016.09.001⟩
Cell, Elsevier, 2016, 167 (1), pp.187-202.e17. ⟨10.1016/j.cell.2016.09.001⟩
Cell, 167(1), 187-+. Cell Press
Cell, 2016, 167 (1), pp.187-202.e17. ⟨10.1016/j.cell.2016.09.001⟩
International audience; Inflammasome complexes function as key innate immune effectors that trigger inflammation in response to pathogen- and danger-associated signals. Here, we report that germline mutations in the inflammasome sensor NLRP1 cause tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4463444006fe6db979bfa8173593c7
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03158675
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03158675
Autor:
Bahloul, Amel, Pepermans, Elise, Raynal, Bertrand, Wolff, Nicolas, Cordier, Florence, England, Patrick, Nouaille, Sylvie, Baron, Bruno, El‐Amraoui, Aziz, Hardelin, Jean‐Pierre, Durand, Dominique, Petit, Christine
Publikováno v:
FEBS Letters
FEBS Letters, Wiley, 2017, 591 (15), pp.2299-2310. ⟨10.1002/1873-3468.12729⟩
FEBS Letters, 2017, 591 (15), pp.2299-2310. ⟨10.1002/1873-3468.12729⟩
FEBS LETTERS
Febs Letters
FEBS Letters, Wiley, 2017, 591 (15), pp.2299-2310. ⟨10.1002/1873-3468.12729⟩
FEBS Letters, 2017, 591 (15), pp.2299-2310. ⟨10.1002/1873-3468.12729⟩
FEBS LETTERS
Febs Letters
International audience; Mutations in the gene encoding harmonin, a multi-PDZ domain-containing submembrane protein, cause Usher syndrome type 1 (congenital deafness and balance disorder, and early-onset sight loss). The structure of the protein and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9d8cb76e0f77cccae966c9861deffb53
https://hal-pasteur.archives-ouvertes.fr/pasteur-01858477
https://hal-pasteur.archives-ouvertes.fr/pasteur-01858477