Functional compensation precedes recovery of tissue mass following acute liver injury

Autor: Ira Fleming, Carolyn Winston, Benjamin Kruft, Alex K. Shalek, Wolfram Goessling, Satdarshan P.S. Monga, Florian Mueller, Sungjin Ko, Udayan Apte, Chad Walesky, Kellie E. Kolb, Jake Henderson

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications, 2020, 11 (1), pp.5785. ⟨10.1038/s41467-020-19558-3⟩

The liver plays a central role in metabolism, protein synthesis and detoxification. It possesses unique regenerative capacity upon injury. While many factors regulating cellular proliferation during liver repair have been identified, the mechanisms b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b098b526816baaea3f6aa2942d407e5
https://doaj.org/article/19ae1c964a6645e69ee2804af9f1cfd1

Isotopomics by isotope ratio monitoring by 13 C nuclear magnetic resonance spectrometry on cutting agents in heroin: A new approach for illicit drugs trafficking route elucidation

Autor: Fabrice Besacier, Valentin Joubert, Serge Akoka, Anne-Marie Schiphorst, Matéo Trébuchet, Anaïs Stemmelen, Virginie Silvestre, Denis Loquet, Mariana Mikic, Virginie Ladroue, Gérald S. Remaud

Publikováno v: Drug Testing and Analysis
Drug Testing and Analysis, John Wiley, 2020, 12 (4), pp.449-457. ⟨10.1002/dta.2745⟩

International audience; In the battle against the illicit drugs market, methodologies have been developed by forensic laboratories to address the determination of the origin and dismantlement of the trafficking route for various target molecules such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03f2144ee91f10508a18cba702e504b
https://hal.archives-ouvertes.fr/hal-03416636

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Étude prospective en pharmacie du bon usage et de la connaissance du paracétamol pris en automédication

Autor: Severin, Anne-Elise, Petitpain, Nadine, Scala-Bertola, Julien, Latarche, Clotilde, Yelehe-Okouma, Melissa, Di Patrizio, Paolo, Gillet, Pierre

Publikováno v: Thérapie
Thérapie, EDP Sciences, 2016, 71 (3), pp.287-296. ⟨10.1016/j.therap.2015.09.003⟩
Alternative and Complementary Therapies
Alternative and Complementary Therapies, Mary Ann Liebert, 2016, 71 (3), pp.287-296. ⟨10.1016/j.therap.2015.09.003⟩

International audience; Acetaminophen (paracetamol), the highest over-the-counter (OTC) selling drug in France, is also the first cause of acute hepatic failure. We aimed to assess the good use and the knowledge of acetaminophen in a setting of urban

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::151f038c7fc1a12679c7052dc342d50f
https://pubmed.ncbi.nlm.nih.gov/27235652

Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice

Autor: Julie Pajaud, Bruno Turlin, Jacinthe Aubert, Karima Begriche, Marie-Anne Robin, Matthieu Delannoy, Mitchell R. McGill, Sylvie Lepage, Catherine Lucas-Clerc, Catherine Ribault, Isabelle Morel, Bernard Fromenty, Hartmut Jaeschke

Publikováno v: Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics, 2012, 342 (3), pp.676-87. ⟨10.1124/jpet.112.193813⟩
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2012, 342 (3), pp.676-87. ⟨10.1124/jpet.112.193813⟩

International audience; Clinical investigations suggest that hepatotoxicity after acetaminophen (APAP) overdose could be more severe in the context of obesity and nonalcoholic fatty liver disease. The pre-existence of fat accumulation and CYP2E1 indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4faefe1d214e569a3bd3923c4e449933
https://www.hal.inserm.fr/inserm-00864718