Zobrazeno 1 - 10
of 266
pro vyhledávání: '"MENOTTI RUVO"'
Autor:
Lorenzo Cuollo, Samuele Di Cristofano, Annamaria Sandomenico, Emanuela Iaccarino, Angela Oliver, Alessandra Zingoni, Marco Cippitelli, Cinzia Fionda, Sara Petillo, Andrea Kosta, Valentina Tassinari, Maria Teresa Petrucci, Francesca Fazio, Menotti Ruvo, Angela Santoni, Domenico Raimondo, Alessandra Soriani
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109814- (2024)
Summary: 2′3′-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) is the endogenous agonist of STING; as such, cGAMP has powerful immunostimulatory activity, due to its capacity to stimulate type I interferon-mediated immunity. Recen
Externí odkaz:
https://doaj.org/article/d8e6f044263540b99c87c79122f65561
Autor:
Carla L. Esposito, Ida Autiero, Annamaria Sandomenico, H. Li, Mahmoud A. Bassal, Maria L. Ibba, Dongfang Wang, Lucrezia Rinaldi, Simone Ummarino, Giulia Gaggi, Marta Borchiellini, Piotr Swiderski, Menotti Ruvo, Silvia Catuogno, Alexander K. Ebralidze, Marcin Kortylewski, Vittorio de Franciscis, Annalisa Di Ruscio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Here the authors generate an RNA-based platform to neutralize the major epigenetic player DNMT1. Using this targeted approach, aberrant DNA methylation in cancer can be corrected.
Externí odkaz:
https://doaj.org/article/1ac7b00822ad42efaffe5d498c64c726
Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications—Second Edition
Autor:
Nunzianna Doti, Menotti Ruvo
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1083 (2024)
Peptides are increasingly emerging as a drug class for a wide range of human diseases due to their intrinsic properties, such as excellent recognition abilities and biocompatibility [...]
Externí odkaz:
https://doaj.org/article/f77a90fd9d674890a5ac6d35bc194718
Autor:
Roberta Pacifico, Nunzio Del Gaudio, Guglielmo Bove, Lucia Altucci, Lydia Siragusa, Gabriele Cruciani, Menotti Ruvo, Rosa Bellavita, Paolo Grieco, Mauro F. A. Adamo
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1987-1994 (2022)
We have recently developed a new synthetic methodology that provided both N-aryl-5-hydroxytriazoles and N-pyridine-4-alkyl triazoles. A selection of these products was carried through virtual screening towards targets that are contemporary and valida
Externí odkaz:
https://doaj.org/article/f9c5fcf1b41543b299f0dd8f3efb65c3
Autor:
Jwala P. Sivaccumar, Emanuela Iaccarino, Angela Oliver, Maria Cantile, Pierpaolo Olimpieri, Antonio Leonardi, Menotti Ruvo, Annamaria Sandomenico
Publikováno v:
Pharmaceuticals, Vol 16, Iss 8, p 1130 (2023)
Drug development in recent years is increasingly focused on developing personalized treatments based on blocking molecules selective for therapeutic targets specifically present in individual patients. In this perspective, the specificity of therapeu
Externí odkaz:
https://doaj.org/article/3af5e9b380eb4d94a97cfec3cd903d04
Unveiling CD59-Antibody Interactions to Design Paratope-Mimicking Peptides for Complement Modulation
Autor:
Annamaria Sandomenico, Alessia Ruggiero, Emanuela Iaccarino, Angela Oliver, Flavia Squeglia, Miguel Moreira, Luciana Esposito, Menotti Ruvo, Rita Berisio
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8561 (2023)
CD59 is an abundant immuno-regulatory human protein that protects cells from damage by inhibiting the complement system. CD59 inhibits the assembly of the Membrane Attack Complex (MAC), the bactericidal pore-forming toxin of the innate immune system.
Externí odkaz:
https://doaj.org/article/3f122dbfa48f4b1e8ac133c57e95f83b
Autor:
Nicole Balasco, Carlo Diaferia, Elisabetta Rosa, Alessandra Monti, Menotti Ruvo, Nunzianna Doti, Luigi Vitagliano
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8372 (2023)
Amyloid aggregation is a widespread process that involves proteins and peptides with different molecular complexity and amino acid composition. The structural motif (cross-β) underlying this supramolecular organization generates aggregates endowed w
Externí odkaz:
https://doaj.org/article/3edc23e33c7e4db0a4f9b356d613e3de
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 7842 (2023)
Protein–protein interfaces play fundamental roles in the molecular mechanisms underlying pathophysiological pathways and are important targets for the design of compounds of therapeutic interest. However, the identification of binding sites on prot
Externí odkaz:
https://doaj.org/article/ba0d9ff5ae0e4c47a4406b28452fdea4
Autor:
Beatrice Cavalluzzo, Concetta Ragone, Angela Mauriello, Annacarmen Petrizzo, Carmen Manolio, Andrea Caporale, Luigi Vitagliano, Menotti Ruvo, Luigi Buonaguro, Maria Tagliamonte
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-10 (2021)
Abstract The antigenicity as well as the immunogenicity of tumor associated antigens (TAAs) may need to be potentiated in order to break the immunological tolerance. To this aim, heteroclitic peptides were designed introducing specific substitutions
Externí odkaz:
https://doaj.org/article/3dc9a84c911147aa88ceca28ee678ec7
Autor:
Maria Tagliamonte, Angela Mauriello, Beatrice Cavalluzzo, Concetta Ragone, Carmen Manolio, Antonio Luciano, Antonio Barbieri, Giuseppe Palma, Giosuè Scognamiglio, Annabella Di Mauro, Maurizio Di Bonito, Maria Lina Tornesello, Franco M. Buonaguro, Luigi Vitagliano, Andrea Caporale, Menotti Ruvo, Luigi Buonaguro
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Tumor Associated Antigens (TAAs) may suffer from an immunological tolerance due to expression on normal cells. In order to potentiate their immunogenicity, heteroclitic peptides (htcPep) were designed according to prediction algorithms. In particular
Externí odkaz:
https://doaj.org/article/2e250e3e95704cb89d81f4e760bcc049