Výsledky vyhledávání - "MEM, minimum essential medium"

Effect of S(−) perillic acid on protein prenylation and arterial smooth muscle cell proliferation☆2☆This research was partially supported by Institut of Recherches Internationales Servier, Paris, France. N. Ferri, L. Arnaboldi, and A. Corsini are also partially supported by a grant from the Ministero dell’Università e della Ricerca Scientifica e Tecnologica (cofinanziamento 1999, progetto 'Role of smooth muscle cells in atherogenesis: pharmacological implications,' protocollo 9905157119. M. H. Gelb and K. Yokoyama are supported by a Grant from the National Institute of Health (CA 52874). A. Corsini is a visiting scientist under the terms of the US (National Heart, Lung, and Blood Institute)-Italy bilateral agreement in the cardiovascular area.2Abbreviations: FOH, farnesol; GGOH, geranylgeraniol; PFTase, protein farnesyltransferase; PGGTase, protein geranylgeranyltransferase; PA, perillic acid; SMC, smooth muscle cell; MVA, mevalonate; HMG-CoA, 3-hydroxy-3-methyl-glutaryl coenzyme A; FCS, fetal calf serum; MEM, Minimum Essential Medium; PBS, phosphate buffered saline; PI, propidium iodide

Autor: Michael H. Gelb, Ali Hachem, René Grée, Kohei Yokoyama, A. Granata, Rodolfo Paoletti, Lorenzo Arnaboldi, Alberto Corsini, Augusto Orlandi, Nicola Ferri

Publikováno v: Biochemical Pharmacology. 62:1637-1645

A number of proteins post-translationally modified by the covalent attachment of mevalonate-derived isoprene groups farnesol (FOH) or geranylgeraniol (GGOH), play a role in cell proliferation. For this reason, protein farnesyltransferase (PFTase) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b430929579c4245db6ec34179e89c2b
https://doi.org/10.1016/s0006-2952(01)00808-5

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Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells11Abbreviations: AhR, aryl hydrocarbon receptor; CAT, chloramphenicol acetyltransferase; DHEA, dehydroepiandrosterone; DIM, diindolylmethane; DME F-12, Dulbecco’s modified Eagle’s medium nutrient mixture F-12 Ham; DRE, dioxin responsive element; DTT, dithiothreitol; EROD, ethoxyresorufin O-deethylase; FBS, fetal bovine serum; MEM, minimum essential medium, and TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin

Autor: Jeong-Eun Lee, Stephen Safe

Publikováno v: Biochemical Pharmacology. 62:1113-1124

Resveratrol decreases basal and induced CYP1A1 mRNA/protein levels in both in vitro and in vivo models, and some studies suggest that resveratrol acts as an aryl hydrocarbon receptor (AhR) antagonist. Treatment of T47D or MCF-7 cells with 10 microM r

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https://doi.org/10.1016/s0006-2952(01)00763-8

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Antitumor effects of ajulemic acid (CT3), a synthetic non-psychoactive cannabinoid 4 4Abbreviations: AJA, ajulemic acid, dimethylheptyl-THC-11-oic acid; DG, diglyceride; FBS, fetal bovine serum; MEM, Minimum Essential Medium; MTT, microculture methyl-thiazolyl tetrazolium; PKC, protein kinase C; TEM, transmission electron microscopy; TG, triglyceride; and THC, tetrahydrocannabinol

Autor: Robert B. Zurier, Pusha Karim, George Pipia, Sumner Burstein, Lawrence Recht, Alonzo H. Ross, N. Scott Litofsky, Ronald Rosetti, Tai Jang, Tomacz Kubiatowski, Rebecca Salmonsen

Publikováno v: Biochemical Pharmacology. 62:755-763

One of the endogenous transformation products of tetrahydrocannabinol (THC) is THC-11-oic acid, and ajulemic acid (AJA; dimethylheptyl-THC-11-oic acid) is a side-chain synthetic analog of THC-11-oic acid. In preclinical studies, AJA has been found to

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https://doi.org/10.1016/s0006-2952(01)00700-6

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Periodical

Antitumor effects of ajulemic acid (CT3), a synthetic non-psychoactive cannabinoid44Abbreviations:AJA, ajulemic acid, dimethylheptyl-THC-11-oic acid; DG, diglyceride; FBS, fetal bovine serum; MEM, Minimum Essential Medium; MTT, microculture methyl-thiazolyl tetrazolium; PKC, protein kinase C; TEM, transmission electron microscopy; TG, triglyceride; and THC, tetrahydrocannabinol.

Autor: Recht, Lawrence D., Salmonsen, Rebecca, Rosetti, Ronald, Jang, Tai, Pipia, George, Kubiatowski, Tomacz, Karim, Pusha, Ross, Alonzo H., Zurier, Robert, Scott Litofsky, N., Burstein, Sumner

Publikováno v: Biochemical Pharmacology; September 2001, Vol. 62 Issue: 6 p755-763, 9p

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Immunosuppressive mesenchymal stem cells aggregates incorporating hydrogel microspheres promote an in vitro invasion of cancer cells

Autor: Teruki Nii, Yasuhiko Tabata

Publikováno v: Regenerative Therapy, Vol 18, Iss, Pp 516-522 (2021)
Regenerative Therapy

Introduction The objective of this study is to design a co-culture system of cancer cells and three-dimensional (3D) mesenchymal stem cells (MSC) aggregates for the in vitro evaluation of cancer invasion. Methods First, the MSC of an immunosuppressiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30478d0d874b865560a7aa85190b7a7e
http://hdl.handle.net/2433/277951

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Subcutaneous transplantation of engineered islet/adipose-derived mesenchymal stem cell sheets in diabetic pigs with total pancreatectomy

Autor: Shinichiro Ono, Kyoichiro Maekawa, Kengo Kanetaka, Mampei Yamashita, Tamotsu Kuroki, Masaaki Hidaka, Toshiyuki Adachi, Naomi Matsumura, Susumu Eguchi, Tomohiko Adachi, Yusuke Sakai

Publikováno v: Regenerative Therapy, Vol 16, Iss, Pp 42-52 (2021)
Regenerative Therapy

Introduction Intraportal islet transplantation is a promising therapeutic approach for patients with type 1 diabetes mellitus (T1DM). However, despite being minimally invasive, the method has some limitations, such as short-term graft loss, portal ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893c069593595c8b4c866ee01a5eb3c2
http://www.sciencedirect.com/science/article/pii/S2352320420301012

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Regenerative effect of mesenteric fat stem cells on ccl4-induced liver cirrhosis, an experimental study

Autor: Fatemeh Namazi, Seifollah Dehghani Nazhvani, Iman Haghani, Abbas Ghaderi, Fatemeh Dehghani Nazhvani

Publikováno v: Annals of Medicine and Surgery

Background Liver cirrhosis is a chronic disease in which normal liver tissue is replaced by fibrous tissue, leads to liver malfunction. Although transplantation is the most certain cure, stem cell therapies are shedding light on efforts to regenerate

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http://europepmc.org/articles/PMC7593263

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Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells

Autor: Dushyantha Jayaweera, Aisha Khan, Xian Ming Chu, Huilan Wang, Michael A. Bellio, Andrea da Fonseca Ferreira, Chunming Dong, Lukun Zhang, Qianhuan Zhang, Joshua M. Hare, Jianqing Wei, Liyong Wang

Publikováno v: JACC: Basic to Translational Science

Visual Abstract
Highlights • EVs derived from young, but not aged, MSCs rejuvenate senescent EPCs in vitro, recapitulating the effect of MSC transplantation. • Aged MSCs can be genetically modified to produce tailored EVs with increased EPC

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http://europepmc.org/articles/PMC7691285

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Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis

Autor: Ping Zhang, Dingyuan Ma, Li-Ying Peng, Ning-Yuan Sun, Jun Chen, Xiao-Wei Zhang, Weiwei Tang, Lin An

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1397-1413 (2020)

Pyroptosis is a form of programmed cell death, and recently described as a new molecular mechanism of chemotherapy drugs in the treatment of tumors. Miltirone, a derivative of phenanthrene-quinone isolated from the root of Salvia miltiorrhiza Bunge,

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http://europepmc.org/articles/PMC7488361

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A cancer invasion model of cancer-associated fibroblasts aggregates combined with TGF-β1 release system

Autor: Teruki Nii, Kimiko Makino, Yasuhiko Tabata

Publikováno v: Regenerative Therapy
Regenerative Therapy, Vol 14, Iss, Pp 196-204 (2020)

Introduction The objective of this study is to design a cancer invasion model where the cancer invasion rate can be regulated in vitro. Methods Cancer-associated fibroblasts (CAF) aggregates incorporating gelatin hydrogel microspheres (GM) containing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c948a87e79509c3976bbda11d75b658e
http://europepmc.org/articles/PMC7058408

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