Evaluation of a downstream process for the recovery and concentration of a Cell-Culture-Derived rVSV-Spike COVID-19 vaccine candidate

Autor: Meni Girshengorn, Ofir Israeli, Lilach Cherry, Edith Lupu, Arnon Tal, Rona Levy, Osnat Rosen, Arik Monash, Einat Toister, Yaron Kafri, Arik Makovitzki, Lilach Levin, Irit Simon, Eyal Dor, Ziv Oren, Elad Lerer, Idan Hefetz, Hanan Tzadok, Yaakov Adar, Eyal Epstein, Ophir Hazan

Publikováno v: Vaccine

rVSV-Spike (rVSV-S) is a recombinant viral vaccine candidate under development to control the COVID-19 pandemic and is currently in phase II clinical trials. rVSV-S induces neutralizing antibodies and protects against SARS-CoV-2 infection in animal m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e15f8ffd652c4297ae37ca1df09a05
https://pubmed.ncbi.nlm.nih.gov/34756612

Coronavirus in water media: Analysis, fate, disinfection and epidemiological applications

Autor: Vincenzo Belgiorno, Florencio C. Ballesteros, Kwang-Ho Choo, Damià Barceló, Shadi W. Hasan, Antonio Buonerba, Gregory V. Korshin, Vincenzo Naddeo, Mary Vermi Aizza Corpuz

Publikováno v: Journal of Hazardous Materials

Considerable attention has been recently given to possible transmission of SARS-CoV-2 via water media. This review addresses this issue and examines the fate of coronaviruses (CoVs) in water systems, with particular attention to the recently availabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fcc30dd3da280a272fb96fe33a3bed
https://doi.org/10.1016/j.jhazmat.2021.125580

An α-synuclein decoy peptide prevents cytotoxic α-synuclein aggregation caused by fatty acid binding protein 3

Autor: Yasuharu Shinoda, Yasushi Yabuki, Yuki Aoyama, Naoya Fukui, Hanae Yamamoto, Kohji Fukunaga, Tomohiro Mizobata, Ichiro Kawahata, Yasushi Kawata, Kunihiro Hongo, Moe Miyabe

Publikováno v: The Journal of Biological Chemistry
Fukui, Naoya. Yamamoto, Hanae. Miyabe, Moe. et al. An α-synuclein decoy peptide prevents cytotoxic α-synuclein aggregation caused by fatty acid binding protein 3. Journal of Biological Chemistry. 296, 100663. 2021-04-20.

α-synuclein (αSyn) is a protein known to form intracellular aggregates during the manifestation of Parkinson’s disease. Previously, it was shown that αSyn aggregation was strongly suppressed in the midbrain region of mice that did not possess th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f65c094ec9071bc126830bb84c2b90b
https://doi.org/10.1016/j.jbc.2021.100663

Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas Gβγ subunits exert opposing effects depending on the G-protein source

Autor: Michelle L. Halls, Dermot M.F. Cooper, Jia Xiao Shen, Sebastian Wachten, Katy L. Everett

Publikováno v: Biochemical Journal

Direct phosphorylation of AC2 (adenylyl cyclase 2) by PKC (protein kinase C) affords an opportunity for AC2 to integrate signals from non-canonical pathways to produce the second messenger, cyclic AMP. The present study shows that stimulation of AC2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd11b40a8af35fdf66cda97c3392abb
https://doi.org/10.1042/bj20120279

Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit

Autor: Agata Rozanska, Sven Dennerlein, Mateusz Wydro, Robert N. Lightowlers, Zofia M.A. Chrzanowska-Lightowlers

Publikováno v: Biochemical Journal

The bacterial Ras-like protein Era has been reported previously to bind 16S rRNA within the 30S ribosomal subunit and to play a crucial role in ribosome assembly. An orthologue of this essential GTPase ERAL1 (Era G-protein-like 1) exists in higher eu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed64bbcdcbb60089936a91ad0f85d58
https://doi.org/10.1042/bj20100757