Výsledky vyhledávání - "MELISSA C. MARR"

Health assessment of gasoline and fuel oxygenate vapors: Developmental toxicity in mice

Autor: Thomas M. Gray, F. J. Murray, Linda G. Roberts, Ceinwen A. Schreiner, Rochelle W. Tyl, Charles R. Clark, Gary M. Hoffman, Melissa C. Marr, GW Trimmer

Publikováno v: Regulatory Toxicology and Pharmacology. 70:S58-S68

Gasoline-vapor condensate (BGVC) or condensed vapors from gasoline blended with methyl t-butyl ether (G/MTBE), ethyl t-butyl ether (G/ETBE), t-amyl methyl ether (G/TAME) diisopropyl ether (G/DIPE), ethanol (G/EtOH), or t-butyl alcohol (G/TBA) were ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9865da0048de0c74201213d7fb84f9b
https://doi.org/10.1016/j.yrtph.2014.06.011

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Validation of the intact rat weanling uterotrophic assay with notes on the formulation and analysis of the positive control chemical in vehicle

Autor: Sherri S. Brown, Melissa C. Marr, Emily A. Dolbow, Rochelle W. Tyl, Christina B. Myers

Publikováno v: Journal of Applied Toxicology. 30:694-698

The intact female weanling version in the Organization for Economic Cooperation and Development (OECD) uterotrophic assay Test Guideline (TG) 440 is proposed as an alternative to the adult ovariectomized female version, because it does not involve su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23580c773eabfbf22f86854ed009a69
https://doi.org/10.1002/jat.1544

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Two-Generation Reproductive Toxicity Study of Dietary Bisphenol A in CD-1 (Swiss) Mice

Autor: Rochelle W. Tyl, R. N. Shiotsuka, Stephen Dimond, Carol Sloan, Steven G. Hentges, Melissa C. Marr, Christina B. Myers, John M. Waechter, Dieter Beyer, M. Michael Veselica, John C. Seely, Nora P. Castillo, John P. Van Miller

Publikováno v: Toxicological Sciences. 104:362-384

Dietary bisphenol A (BPA) was evaluated in a mouse two-generation study at 0, 0.018, 0.18, 1.8, 30, 300, or 3500 ppm (0, 0.003, 0.03, 0.3, 5, 50, or 600 mg BPA/kg/day, 28 per sex per group). A concurrent positive control group of dietary 17beta-estra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ceb3a8134b55e70d8f8aba7ed5eeb1
https://doi.org/10.1093/toxsci/kfn084

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One-generation reproductive toxicity study of dietary 17β-estradiol (E2; CAS No. 50-28-2) in CD-1® (Swiss) mice

Autor: Steven G. Hentges, Stephen S. Dimond, Rochelle W. Tyl, M. Michael Veselica, Melissa C. Marr, Nora P. Castillo, Gisela D. Stropp, Christina B. Myers, R. L. Joiner, John P. Van Miller, John M. Waechter

Publikováno v: Reproductive Toxicology. 25:144-160

There is no information on reproductive/developmental effects in mice from dietary estrogen. Therefore, 10 adult CD-1 mice/sex/group were administered dietary 17beta-estradiol (E2) at 0, 0.005, 0.05, 0.5, 2.5, 5, 10, and 50 ppm for 2-week prebreed, m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2b0aac26804175f2fa686556b5875c
https://doi.org/10.1016/j.reprotox.2007.11.012

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Two-Generation Reproductive Toxicity Evaluation of Dietary 17β-Estradiol (E2; CAS No. 50-28-2) in CD-1 (Swiss) Mice

Autor: Melissa C. Marr, Gisela D. Stropp, Stephen S. Dimond, Ronald S. Shiotsuka, John P. Van Miller, Nora P. Castillo, Steven G. Hentges, John M. Waechter, Rochelle W. Tyl, John C. Seely, M. Michael Veselica, Carol Sloan, Christina B. Myers

Publikováno v: Toxicological Sciences. 102:392-412

No information exists on reproductive/developmental effects in mice exposed to dietary 17beta-estradiol (E2) over multiple generations. Therefore, under OECD Test Guideline 416 with enhancements, CD-1 mice (F0 generation, 25 mice/sex/group) were expo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0202df34eea67e2254a1cc1650751494
https://doi.org/10.1093/toxsci/kfn002

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The cyanobacterial toxin, cylindrospermopsin, induces fetal toxicity in the mouse after exposure late in gestation

Autor: M. I. Gage, Melissa C. Marr, E.H. Rogers, RD Zehr, Ian R. Falconer, Andrew R. Humpage, Neil Chernoff

Publikováno v: Toxicon. 49:855-864

Cylindrospermopsin (cyn) is a cyanobacterial toxin implicated in human and wildlife poisonings. We have completed studies investigating the potential of purified cyn to induce developmental toxicity in mammals. The teratology study involved intraperi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80aff2a332c5734affc93f229a0ceb1b
https://doi.org/10.1016/j.toxicon.2006.12.009

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Three-Generation Evaluation of Dietary para-Nonylphenol in CD (Sprague-Dawley) Rats

Autor: John C. Seely, M. Michael Veselica, Glenn S. Simon, Rochelle W. Tyl, Christina B. Myers, Carol Sloan, Nora P. Castillo, Melissa C. Marr, R. L. Joiner, John P. Van Miller

Publikováno v: Toxicological Sciences. 92:295-310

This study evaluated the potential for dietary para-nonylphenol (NP; CAS No. 84852-15-3) to affect parental fertility and growth and development of three offspring generations in CD (Sprague-Dawley [SD]) rats, including sperm counts across generation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ae376cd3704b58ba1a3f689dabd12f
https://doi.org/10.1093/toxsci/kfj203

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Prenatal developmental toxicity evaluation of 2′,3′-dideoxyinosine (ddI) and 2′,3′-didehydro-3′-deoxythymidine (d4T) co-administered to Swiss Albino (CD-1) mice

Autor: Christina B. Myers, Rick Williams, Melissa C. Marr, Gayle Bieler, Catherine J. Price, Julia D. George, Gloria D. Jahnke

Publikováno v: Birth Defects Research Part B: Developmental and Reproductive Toxicology. 77:207-215

BACKGROUND: In pregnant women, antiretroviral drugs improve maternal health and reduce vertical transmission of human immunodeficiency virus to the infant. However, few nonclinical studies have examined the potential for adverse drug interactions. ME

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4a2a6f24199052f63388f3acaca4d3
https://doi.org/10.1002/bdrb.20076

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Reproductive toxicity evaluation of dietary butyl benzyl phthalate (BBP) in rats

Autor: Rochelle W. Tyl, John H. Butala, Robert A. Barter, Patricia A. Fail, John C. Seely, Melissa C. Marr, Christina B. Myers, Dolores R. Brine

Publikováno v: Reproductive Toxicology. 18:241-264

Butyl benzyl phthalate (BBP) was administered in the diet at 0, 750, 3750, and 11,250 ppm ad libitum to 30 rats per sex per dose for two offspring generations, one litter/breeding pair/generation, through weaning of F2 litters. Adult F0 systemic toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e79e8f9c708c8bef5c98deee85b2cf
https://doi.org/10.1016/j.reprotox.2003.10.006

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Two-generation reproductive toxicity study of inhaled tertiary amyl methyl ether (TAME) vapor in CD®rats

Autor: A James, Rochelle W. Tyl, Frank Welsch, John C. Seely, Patricia A. Fail, Melissa C. Marr, Christina B. Myers, Barbara A. Elswick

Publikováno v: Journal of Applied Toxicology. 23:397-410

Under Office of Prevention, Pesticides and Toxic Substances draft guidelines, CD weanling F0 rats (30 of each gender per group) inhaled tertiary amyl methyl ether vapor at 0, 250, 1500 or 3000 ppm 5 days a week and 6 h a day for 10 weeks, with vagina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdb108a36d13627ee1bc31a08df241c1
https://doi.org/10.1002/jat.928

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