A novel regimen for pancreatic ductal adenocarcinoma targeting MEK, BCL-xL, and EGFR

Autor: Song Han, Gerik W. Tushoski-Alemán, Peiyi Zhang, Guangrong Zheng, Daohong Zhou, Zhiguang Huo, Jonathan Licht, Thomas J. George, Carmen Allegra, Jose G. Trevino, Steven J. Hughes

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 59, Iss , Pp 101070- (2025)

Oncogenic KRAS signaling plays a critical role in pancreatic ductal adenocarcinoma (PDAC) biology. Recent studies indicate that the combination of MEK and BCL-xL inhibition is synthetically lethal and holds promise for some types of solid cancers, ho

Externí odkaz: https://doaj.org/article/191df517e9ab4a0b927c1c49c80b247d

Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects

Autor: Hui Ao, Fei Tang, Jing Wang, Yu-Zhu Tan, Yan Wan, Lu Chen, Cheng Peng, Jin-feng Xu, Chao-long Rao

Publikováno v: Journal of Ginseng Research, Vol 45, Iss 6, Pp 617-630 (2021)
Journal of Ginseng Research

Chemotherapy-induced side effects affect the quality of life and efficacy of treatment of cancer patients. Current approaches for treating the side effects of chemotherapy are poorly effective and may cause numerous harmful side effects. Therefore, d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddba476a926baf2ffce4db535797ce9
https://doi.org/10.1016/j.jgr.2021.03.001

Propionate Enhances Cell Speed and Persistence to Promote Intestinal Epithelial Turnover and RepairSummary

Autor: Sara M. Dann, Zheng Zhou, Suxia Yao, Wenjing Yang, Anthony J. Bilotta, Yu Yu, Xiaojing Zhao, Chunyan Ma, Yingzi Cong, Yanbo Yu

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1023-1044 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background and Aims Gut bacteria-derived short-chain fatty acids (SCFAs) play crucial roles in the maintenance of intestinal homeostasis. However, how SCFAs regulate epithelial turnover and tissue repair remain incompletely understood. In this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d4114ca3e9339e1b8954fbfbdd4b9d
http://www.sciencedirect.com/science/article/pii/S2352345X20301909

Oncogenic Gq/11 signaling acutely drives and chronically sustains metabolic reprogramming in uveal melanoma

Autor: Michael D. Onken, Sarah E. Noda, Kevin M. Kaltenbronn, Cheryl Frankfater, Carol M. Makepeace, Nikki Fettig, Kisha D. Piggott, Philip L. Custer, Joseph E. Ippolito, Kendall J. Blumer

Publikováno v: The Journal of Biological Chemistry

Metabolic reprogramming has been shown to occur in uveal melanoma (UM), the most common intraocular tumor in adults. Mechanisms driving metabolic reprogramming in UM are poorly understood. Elucidation of these mechanisms could inform development of n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75e9c1da7a1bf50b5ce0880b781fb6f
http://europepmc.org/articles/PMC8761705

The BTB-domain transcription factor ZBTB2 recruits chromatin remodelers and a histone chaperone during the exit from pluripotency

Autor: Anaïs F. Bardet, Daniel Hess, Daniel Olivieri, Sébastien A. Smallwood, Ulrich Elling, Sujani Paramanathan, Joerg Betschinger

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (2), pp.100947. ⟨10.1016/j.jbc.2021.100947⟩
The Journal of Biological Chemistry

Transcription factors (TFs) harboring broad-complex, tramtrack, and bric-a-brac (BTB) domains play important roles in development and disease. These BTB domains are thought to recruit transcriptional modulators to target DNA regions. However, a syste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026739c7c937a26878c6cad73fcd7ad9