Zobrazeno 1 - 10
of 363
pro vyhledávání: '"MEIJER, DKF"'
Autor:
Geesink Jh, Meijer Dkf
Publikováno v:
Biomedical Research and Reviews. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fe7d401f837e14e2ab61f6c6a6737a6
https://doi.org/10.15761/brr.1000111
https://doi.org/10.15761/brr.1000111
Autor:
Gonzalo, T, Talman, EG, de Ven, AV, Temming, K, Greupink, R, Beljaars, L, Reker-Smit, C, Meijer, DKF, Molema, G, Poelstra, K, Kok, RJ
Publikováno v:
Journal of Controlled Release, 111(1-2), 193-203. Elsevier Bedrijfsinformatie b.v.
Targeting of antifibrotic drugs to hepatic stellate cells (HSC) is a promising strategy to block fibrotic processes leading to liver cirrhosis. For this purpose, we utilized the neo-glycoprotein mannose-6-phosphate-albumin (M6PHSA) that accumulates e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::cbe0e0b58bbe6bbb60195aa88de52257
https://research.rug.nl/en/publications/c8706f85-f9fa-49e3-a397-a0ff55a44849
https://research.rug.nl/en/publications/c8706f85-f9fa-49e3-a397-a0ff55a44849
Autor:
Haverdings, RGF, Haas, M, Navis, GJ, van Loenen-Weemaes, AMA, Meijer, DKF, de Zeeuw, D, Moolenaar, F
Publikováno v:
British Journal of Pharmacology, 138(4), 1107-1116. Wiley-Blackwell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::fa06fce3f43bf8867a56c618ba0fb715
https://research.rug.nl/en/publications/c30b8269-8581-4aa5-8bd4-1bf93a4e154b
https://research.rug.nl/en/publications/c30b8269-8581-4aa5-8bd4-1bf93a4e154b
Publikováno v:
Pharmaceutical Research, 19(11), 1730-1735. SPRINGER/PLENUM PUBLISHERS
Purpose. For selective inhibition of endothelial cell activation in chronic inflammation, we have developed a dexamethasone-anti-E-selectin immunoconjugate. The present study was performed to evaluate the cellular handling of this immunoconjugate by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::4407c7b57bf4de0d1a170eadbdada51a
https://research.rug.nl/en/publications/f02a201c-894a-4ec4-a1c5-642874a86c27
https://research.rug.nl/en/publications/f02a201c-894a-4ec4-a1c5-642874a86c27
Autor:
Haverdings, RFG, Haas, M, Navis, G, van Loenen-Weemaes, AM, Meijer, DKF, de Zeeuw, D, Moolenaar, F
Publikováno v:
British Journal of Pharmacology, 136(8), 1107-1116. Wiley-Blackwell
1 In previous studies on the renal targeting of the ACE inhibitor captopril, we demonstrated that a 6 fold increased concentration of this drug could be obtained in the kidney after conjugation to the low-molecular-weight protein lysozyme. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::3bfb6b3eb886a36cd75d741827d2f457
https://research.rug.nl/en/publications/25749725-6958-4e3c-9db4-932e1ac94063
https://research.rug.nl/en/publications/25749725-6958-4e3c-9db4-932e1ac94063
Publikováno v:
Pharmaceutical Research, 19(5):UNSP 0724-8741/02/0500-0676/0, 676-680. SPRINGER/PLENUM PUBLISHERS
Purpose. Previously we reported on massive uptake of liposomes surface-modified with negatively charged aconitylated albumin (Aco-HSA) by liver sinusoidal endothelial cells (EC) in vivo. In the present work we applied this principle for the in vivo d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::acd295ab0ae0ea88e3d280df832ade79
https://research.rug.nl/en/publications/e109ef28-eaeb-4499-88f8-168a9b07381d
https://research.rug.nl/en/publications/e109ef28-eaeb-4499-88f8-168a9b07381d
Autor:
Kok, RJ, Asgeirsdottir, SA, Melgert, BN, Moolenaar, TJM, Koning, GA, van Luyn, MJA, Meijer, DKF, Molema, G
Publikováno v:
Journal of Immunology, 168(2), 883-889. AMER ASSOC IMMUNOLOGISTS
In chronic inflammatory diseases, the endothelium is an attractive target for pharmacological intervention because it plays an important role in leukocyte recruitment. Hence, inhibition of endothelial cell activation and consequent leukocyte infiltra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::01dff949de8facc12327f511dd567dec
https://research.rug.nl/en/publications/15ee9478-4cfe-4756-bbb7-0d7c75b63177
https://research.rug.nl/en/publications/15ee9478-4cfe-4756-bbb7-0d7c75b63177
Publikováno v:
Drug Metabolism and Disposition, 29(4), 361-367. AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
We developed and tested a novel method for perfusing parts of human liver to study uptake and handling of drug-targeting preparations. These preparations, designed for the treatment of liver fibrosis in man, have been extensively studied in animals,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::cac5731d6f7d178bed3e1f7e3c82277a
https://research.rug.nl/en/publications/0c73791c-5084-410b-b686-22e645315e06
https://research.rug.nl/en/publications/0c73791c-5084-410b-b686-22e645315e06
Autor:
Olinga, P, Hof, IH, Smit, M, de Jager, MH, Swart, PJ, Slooff, MJH, Meijer, DKF, Groothuis, GMM, Merema, M.T.
Publikováno v:
Journal of Pharmacological and Toxicological Methods, 45(1), 55-63
In the present study we investigated the applicability of the liver slice model to study mechanisms of drug uptake. Four model compounds were investigated that enter hepatocytes via entirely different membrane transport mechanisms. Rhodamine B (RB),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::dc7560045ec96c12ecc4ac89d72e0b6b
https://research.rug.nl/en/publications/a0d631ab-1b09-4573-a3cb-054934919e61
https://research.rug.nl/en/publications/a0d631ab-1b09-4573-a3cb-054934919e61
Publikováno v:
Liver, 20(5), 374-380
Aims/Background: In liver transplantation, adequate function tests for donor livers and transplanted livers are of utmost importance to provide an objective basis for decision-making. Isolated hepatocyte and/or slice preparations from human donor liv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::732f3b4a3745a4685f04e8cc59b958bf
https://research.rug.nl/en/publications/dfd08fdf-79e4-482b-81d8-40e4b7cd5f6e
https://research.rug.nl/en/publications/dfd08fdf-79e4-482b-81d8-40e4b7cd5f6e