Codon-specific KRAS mutations predict survival benefit of trifluridine/tipiracil in metastatic colorectal cancer

Autor: Joris van de Haar, Xuhui Ma, Salo N. Ooft, Pim W. van der Helm, Louisa R. Hoes, Sara Mainardi, David J. Pinato, Kristi Sun, Lisa Salvatore, Giampaolo Tortora, Ina Valeria Zurlo, Silvana Leo, Riccardo Giampieri, Rossana Berardi, Fabio Gelsomino, Valeria Merz, Federica Mazzuca, Lorenzo Antonuzzo, Gerardo Rosati, Chara Stavraka, Paul Ross, Maria Grazia Rodriquenz, Michele Pavarana, Carlo Messina, Timothy Iveson, Federica Zoratto, Anne Thomas, Elisabetta Fenocchio, Margherita Ratti, Ilaria Depetris, Massimiliano Cergnul, Cristina Morelli, Michela Libertini, Alessandro Parisi, Michele De Tursi, Nicoletta Zanaletti, Ornella Garrone, Janet Graham, Raffaella Longarini, Stefania Maria Gobba, Angelica Petrillo, Emiliano Tamburini, Nicla La Verde, Fausto Petrelli, Vincenzo Ricci, Lodewyk F. A. Wessels, Michele Ghidini, Alessio Cortellini, Emile E. Voest, Nicola Valeri

Publikováno v: Nature Medicine

Genomics has greatly improved how patients with cancer are being treated; however, clinical-grade genomic biomarkers for chemotherapies are currently lacking. Using whole-genome analysis of 37 patients with metastatic colorectal cancer (mCRC) treated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb49b9ab0cd07171cb1da7854395935
https://doi.org/10.1038/s41591-023-02240-8

Cancer prevention: innovative strategies in the role of the European Cancer Prevention Organization

Autor: Corso, G., Janssens, J.P., La Vecchia, C.

Publikováno v: European Journal of Cancer Prevention. 32:203-206

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0853049f4a882199ad8119d0ce6d42b
https://doi.org/10.1097/cej.0000000000000782

European Groundshot—addressing Europe's cancer research challenges: a Lancet Oncology Commission

Autor: Mark Lawler, Lynne Davies, Simon Oberst, Kathy Oliver, Alexander Eggermont, Anna Schmutz, Carlo La Vecchia, Claudia Allemani, Yolande Lievens, Peter Naredi, Tanja Cufer, Ajay Aggarwal, Matti Aapro, Kathi Apostolidis, Anne-Marie Baird, Fatima Cardoso, Andreas Charalambous, Michel P Coleman, Alberto Costa, Mirjam Crul, Csaba L Dégi, Federica Di Nicolantonio, Sema Erdem, Marius Geanta, Jan Geissler, Jacek Jassem, Beata Jagielska, Bengt Jonsson, Daniel Kelly, Olaf Kelm, Teodora Kolarova, Tezer Kutluk, Grant Lewison, Françoise Meunier, Jana Pelouchova, Thierry Philip, Richard Price, Beate Rau, Isabel T Rubio, Peter Selby, Maja Južnič Sotlar, Gilliosa Spurrier-Bernard, Jolanda C van Hoeve, Eduard Vrdoljak, Willien Westerhuis, Urszula Wojciechowska, Richard Sullivan

Publikováno v: Lawler, M, Davies, L, Oberst, S, Oliver, K, Eggermont, A, Schmutz, A, La Vecchia, C, Allemani, C, Lievens, Y, Naredi, P, Cufer, T, Aggarwal, A, Aapro, M, Apostolidis, K, Baird, A-M, Cardoso, F, Charalambous, A, Coleman, M P, Costa, A, Crul, M, Dégi, C L, Di Nicolantonio, F, Erdem, S, Geanta, M, Geissler, J, Jassem, J, Jagielska, B, Jonsson, B, Kelly, D, Kelm, O, Kolarova, T, Kutluk, T, Lewison, G, Meunier, F, Pelouchova, J, Philip, T, Price, R, Rau, B, Rubio, I T, Selby, P, Južnič Sotlar, M, Spurrier-Bernard, G, van Hoeve, J C, Vrdoljak, E, Westerhuis, W, Wojciechowska, U & Sullivan, R 2023, ' European Groundshot-addressing Europe's cancer research challenges : a Lancet Oncology Commission ', Lancet Oncology, vol. 24, no. 1, pp. e11-e56 . https://doi.org/10.1016/S1470-2045(22)00540-X

Cancer research is a crucial pillar for countries to deliver more affordable, higher quality, and more equitable cancer care. Patients treated in research-active hospitals have better outcomes than patients who are not treated in these settings. Howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e07d8fcab1f498ebdd71513b8c10c4d
https://doi.org/10.1016/s1470-2045(22)00540-x

The prognostic role of systemic inflammatory markers in apparent early-stage ovarian cancer

Autor: Nicolò Bizzarri, Marco D’Indinosante, Claudia Marchetti, Riccardo Tudisco, Francesca Turchiano, Giovanni Scambia, Anna Fagotti

Publikováno v: International Journal of Clinical Oncology. 28:314-320

Background Few studies analyzed the prognostic role of systemic inflammatory markers in early-stage ovarian cancer. The primary endpoint of the present study was to assess the prognostic impact of baseline inflammatory markers in early-stage ovarian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c0706a348a9fd7b9f548788d264f7a
https://doi.org/10.1007/s10147-022-02272-z

Application of histology-agnostic treatments in metastatic colorectal cancer

Autor: Andrea Sartore-Bianchi, Alberto Giuseppe Agostara, Giorgio Patelli, Gianluca Mauri, Elio Gregory Pizzutilo, Salvatore Siena

Publikováno v: Digestive and Liver Disease. 54:1291-1303

Cancer treatment is increasingly focused on targeting molecular alterations identified across different tumor histologies. While some oncogenic drivers such as microsatellite instability (MSI) and NTRK fusions are actionable with the very same approa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96621a1fa312b4b8b79527f4a04e5e58
https://doi.org/10.1016/j.dld.2022.05.013