Proton Bridging in Catalysis by and Inhibition of Serine Proteases of the Blood Cascade System

Autor: Ildiko M Kovach

Publikováno v: Life, Vol 11, Iss 5, p 396 (2021)

Inquiries into the participation of short hydrogen bonds in stabilizing transition states and intermediate states in the thrombin, factor Xa, plasmin and activated protein C–catalyzed reactions revealed that specific binding of effectors at Sn, n =

Externí odkaz: https://doaj.org/article/ef264daecd664b89bb239ab26f9b3576

The Synthesis and Glycoside Formation of Polyfluorinated Carbohydrates

Autor: Kler Huonnic, Bruno Linclau

Publikováno v: CHEMICAL REVIEWS

Fluorinated carbohydrates have found many applications in the glycosciences. Typically, these contain fluorination at a single position. There are not many applications involving polyfluorinated carbohydrates, here defined as monosaccharides in which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5174b3e01206289db545616838af8a00
https://pubmed.ncbi.nlm.nih.gov/35613331

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Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme**

Autor: Nima Rajabi, Tobias N. Hansen, Alexander L. Nielsen, Huy T. Nguyen, Michael Bæk, Julie. E. Bolding, Oskar Ø. Bahlke, Sylvester E. G. Petersen, Christian R. O. Bartling, Kristian Strømgaard, Christian A. Olsen

Publikováno v: Rajabi, N, Hansen, T N, Nielsen, A L, Nguyen, H T, Bæk, M, Bolding, J E, Bahlke, O, Petersen, S E G, Bartling, C R O, Strømgaard, K & Olsen, C A 2022, ' Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme** ', Angewandte Chemie-International Edition, vol. 61, no. 22, e202115805 . https://doi.org/10.1002/anie.202115805

Sirtuin 5 (SIRT5) is a protein lysine deacylase enzyme that regulates diverse biology by hydrolyzing ϵ-N-carboxyacyllysine posttranslational modifications in the cell. Inhibition of SIRT5 has been linked to potential treatment of several cancers but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956ebf1e24bd8815528df1bf86d2fcfe
https://curis.ku.dk/portal/da/publications/investigation-of-carboxylic-acid-isosteres-and-prodrugs-for-inhibition-of-the-human-sirt5-lysine-deacylase-enzyme(30614323-0e9e-4a4a-a1f4-3ac1d53aea94).html

Metallo-β-Lactamase Inhibitors Inspired on Snapshots from the Catalytic Mechanism

Autor: Alejandro J. Vila, Maria-Agustina Rossi, Antonella R Palacios, Graciela S Mahler

Publikováno v: Biomolecules, Vol 10, Iss 854, p 854 (2020)
Biomolecules
RepHipUNR (UNR)
Universidad Nacional de Rosario
instacron:UNR

β-Lactam antibiotics are the most widely prescribed antibacterial drugs due to their low toxicity and broad spectrum. Their action is counteracted by different resistance mechanisms developed by bacteria. Among them, the most common strategy is the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a577c309e44cd817d67400856ddddd59
https://www.mdpi.com/2218-273X/10/6/854