Inflammation and Syndecan-4 Shedding from Cardiac Cells in Ischemic and Non-Ischemic Heart Disease.

Autor: Strand ME; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway., Vanhaverbeke M; Cardiology Department, AZ Delta, 8800 Roeselare, Belgium., Henkens MTHM; Netherlands Heart Institute (NLHI), 3511 EP Utrecht, The Netherlands.; Department of Pathology, CARIM, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands.; Department of Cardiology, CARIM, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands., Sikking MA; Department of Cardiology, CARIM, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands., Rypdal KB; Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway.; K.G. Jebsen Center for Cardiac Biomarkers, University of Oslo, 0315 Oslo, Norway.; Division of Diagnostics and Technology, Akershus University Hospital, 1478 Lørenskog, Norway., Braathen B; Department of Cardiothoracic Surgery, Oslo University Hospital Ullevål, 0450 Oslo, Norway., Almaas VM; Department of Cardiology, Oslo University Hospital Rikshospitalet, 0372 Oslo, Norway., Tønnessen T; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway.; Department of Cardiothoracic Surgery, Oslo University Hospital Ullevål, 0450 Oslo, Norway., Christensen G; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway., Heymans S; Department of Cardiovascular Science, University of Leuven, 3000 Leuven, Belgium., Lunde IG; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway.; K.G. Jebsen Center for Cardiac Biomarkers, University of Oslo, 0315 Oslo, Norway.; Division of Diagnostics and Technology, Akershus University Hospital, 1478 Lørenskog, Norway.

Publikováno v: Biomedicines [Biomedicines] 2023 Apr 01; Vol. 11 (4). Date of Electronic Publication: 2023 Apr 01.

The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFβ signalling in cardiac fibroblasts.

Autor: Rypdal KB; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Building 7, 4th floor, Kirkeveien 166, 0407, Oslo, Norway.; KG Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway., Erusappan PM; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Building 7, 4th floor, Kirkeveien 166, 0407, Oslo, Norway.; KG Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway., Melleby AO; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Building 7, 4th floor, Kirkeveien 166, 0407, Oslo, Norway.; KG Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway.; Section of Physiology, Department of Molecular Medicine, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway., Seifert DE; Department of Biomedical Engineering, Cleveland Clinic Lerner Institute, Cleveland, OH, USA., Palmero S; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Building 7, 4th floor, Kirkeveien 166, 0407, Oslo, Norway.; KG Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway., Strand ME; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Building 7, 4th floor, Kirkeveien 166, 0407, Oslo, Norway.; KG Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway., Tønnessen T; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Building 7, 4th floor, Kirkeveien 166, 0407, Oslo, Norway.; KG Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway.; Department of Cardiothoracic Surgery, Oslo University Hospital Ullevaal, Oslo, Norway., Dahl CP; Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway., Almaas V; Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway., Hubmacher D; Orthopaedic Research Laboratories, Leni & Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Apte SS; Department of Biomedical Engineering, Cleveland Clinic Lerner Institute, Cleveland, OH, USA., Christensen G; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Building 7, 4th floor, Kirkeveien 166, 0407, Oslo, Norway.; KG Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway., Lunde IG; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Building 7, 4th floor, Kirkeveien 166, 0407, Oslo, Norway. i.g.lunde@medisin.uio.no.; KG Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway. i.g.lunde@medisin.uio.no.

Publikováno v: Scientific reports [Sci Rep] 2021 Oct 05; Vol. 11 (1), pp. 19757. Date of Electronic Publication: 2021 Oct 05.

The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload.

Autor: Mohammadzadeh N; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; KG Jebsen Center for Cardiac Research, University of Oslo and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway., Lunde IG; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; KG Jebsen Center for Cardiac Research, University of Oslo and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway.; Center for Molecular Medicine Norway, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Andenæs K; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; KG Jebsen Center for Cardiac Research, University of Oslo and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway., Strand ME; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; KG Jebsen Center for Cardiac Research, University of Oslo and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway., Aronsen JM; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; Bjørknes College, Oslo, Norway., Skrbic B; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; KG Jebsen Center for Cardiac Research, University of Oslo and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway.; Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway., Marstein HS; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; KG Jebsen Center for Cardiac Research, University of Oslo and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway., Bandlien C; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; KG Jebsen Center for Cardiac Research, University of Oslo and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway.; Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway., Nygård S; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; KG Jebsen Center for Cardiac Research, University of Oslo and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway.; Department of Informatics, University of Oslo, Oslo, Norway., Gorham J; Department of Genetics, Harvard Medical School, Boston, MA, USA., Sjaastad I; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; KG Jebsen Center for Cardiac Research, University of Oslo and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway., Chakravarti S; Department of Medicine, Johns Hopkins University, Baltimore, PhD, USA.; Department of Ophthalmology and Pathology, NYU Langone Health, Alexandria Life Sciences Center, West Tower, New York, NY, NY10011, USA., Christensen G; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; KG Jebsen Center for Cardiac Research, University of Oslo and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway., Engebretsen KVT; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; KG Jebsen Center for Cardiac Research, University of Oslo and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway.; Department of Surgery, Vestre Viken Hospital, Drammen, Norway., Tønnessen T; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway. theis.tonnessen@medisin.uio.no.; KG Jebsen Center for Cardiac Research, University of Oslo and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway. theis.tonnessen@medisin.uio.no.; Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway. theis.tonnessen@medisin.uio.no.

Publikováno v: Scientific reports [Sci Rep] 2019 Jun 24; Vol. 9 (1), pp. 9206. Date of Electronic Publication: 2019 Jun 24.

The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling.

Autor: Melleby AO; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; Center for Heart Failure Research, University of Oslo, Oslo, Norway., Strand ME; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; Center for Heart Failure Research, University of Oslo, Oslo, Norway., Romaine A; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; Center for Heart Failure Research, University of Oslo, Oslo, Norway., Herum KM; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; Center for Heart Failure Research, University of Oslo, Oslo, Norway., Skrbic B; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; Center for Heart Failure Research, University of Oslo, Oslo, Norway.; Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway., Dahl CP; Center for Heart Failure Research, University of Oslo, Oslo, Norway.; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway., Sjaastad I; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; Center for Heart Failure Research, University of Oslo, Oslo, Norway.; Division of Molecular and Cellular Biology, Sunnybrook Research Institute and Department of Medical Biophysics, University of Toronto, Toronto, Canada., Fiane AE; Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway., Filmus J; Division of Molecular and Cellular Biology, Sunnybrook Research Institute and Department of Medical Biophysics, University of Toronto, Toronto, Canada., Christensen G; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; Center for Heart Failure Research, University of Oslo, Oslo, Norway., Lunde IG; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; Center for Heart Failure Research, University of Oslo, Oslo, Norway.

Publikováno v: PloS one [PLoS One] 2016 Oct 21; Vol. 11 (10), pp. e0165079. Date of Electronic Publication: 2016 Oct 21 (Print Publication: 2016).

Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice.

Autor: Skrbic B; Department of Cardiothoracic Surgery, Oslo University Hospital Ullevål, Kirkeveien 166, Oslo 0407, Norway Faculty of Medicine, University of Oslo, Oslo, Norway KG Jebsen Centre for Cardiac Research and Center for Heart Failure Research, University of Oslo, Oslo, Norway Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway., Engebretsen KV; Department of Cardiothoracic Surgery, Oslo University Hospital Ullevål, Kirkeveien 166, Oslo 0407, Norway Faculty of Medicine, University of Oslo, Oslo, Norway KG Jebsen Centre for Cardiac Research and Center for Heart Failure Research, University of Oslo, Oslo, Norway Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway., Strand ME; KG Jebsen Centre for Cardiac Research and Center for Heart Failure Research, University of Oslo, Oslo, Norway Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway., Lunde IG; KG Jebsen Centre for Cardiac Research and Center for Heart Failure Research, University of Oslo, Oslo, Norway Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway Department of Genetics, Harvard` Medical School, Boston, MA, USA., Herum KM; KG Jebsen Centre for Cardiac Research and Center for Heart Failure Research, University of Oslo, Oslo, Norway Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway., Marstein HS; Department of Cardiothoracic Surgery, Oslo University Hospital Ullevål, Kirkeveien 166, Oslo 0407, Norway KG Jebsen Centre for Cardiac Research and Center for Heart Failure Research, University of Oslo, Oslo, Norway Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway., Sjaastad I; Faculty of Medicine, University of Oslo, Oslo, Norway KG Jebsen Centre for Cardiac Research and Center for Heart Failure Research, University of Oslo, Oslo, Norway Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway., Lunde PK; KG Jebsen Centre for Cardiac Research and Center for Heart Failure Research, University of Oslo, Oslo, Norway Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway., Carlson CR; KG Jebsen Centre for Cardiac Research and Center for Heart Failure Research, University of Oslo, Oslo, Norway Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway., Christensen G; Faculty of Medicine, University of Oslo, Oslo, Norway KG Jebsen Centre for Cardiac Research and Center for Heart Failure Research, University of Oslo, Oslo, Norway Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway., Bjørnstad JL; Department of Cardiothoracic Surgery, Oslo University Hospital Ullevål, Kirkeveien 166, Oslo 0407, Norway KG Jebsen Centre for Cardiac Research and Center for Heart Failure Research, University of Oslo, Oslo, Norway., Tønnessen T; Department of Cardiothoracic Surgery, Oslo University Hospital Ullevål, Kirkeveien 166, Oslo 0407, Norway Faculty of Medicine, University of Oslo, Oslo, Norway KG Jebsen Centre for Cardiac Research and Center for Heart Failure Research, University of Oslo, Oslo, Norway theis.tonnessen@medisin.uio.no theistonnessen@hotmail.com thto@uus.no.

Publikováno v: Cardiovascular research [Cardiovasc Res] 2015 Apr 01; Vol. 106 (1), pp. 32-42. Date of Electronic Publication: 2015 Feb 17.