Loss of the chromatin modifier Kdm2aa causes BrafV-600E -independent spontaneous melanoma in zebrafish

Autor: E. Elizabeth Patton, Zsofia Digby, Sonia Wojciechowska, John E. Collins, Richard White, Elisabeth M. Busch-Nentwich, Catherine M Scahill, ME Mathers, Derek L. Stemple, Till Bartke, Ian M Sealy

Publikováno v: PLoS Genet. 13:e1006959 (2017)
PLoS Genetics
Scahill, C M, Digby, Z, Sealy, I M, Wojciechowska, S, White, R J, Collins, J E, Stemple, D L, Bartke, T, Mathers, M E, Patton, E E & Busch-Nentwich, E M 2017, ' Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish ', PLoS Genetics, vol. 13, no. 8, pp. e1006959 . https://doi.org/10.1371/journal.pgen.1006959
PLoS Genetics, Vol 13, Iss 8, p e1006959 (2017)
PLOS Genetics

KDM2A is a histone demethylase associated with transcriptional silencing, however very little is known about its in vivo role in development and disease. Here we demonstrate that loss of the orthologue kdm2aa in zebrafish causes widespread transcript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad57401fdf2e5551146bcaa025006a9
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=51870

Generating and Analyzing Fish Models of Melanoma

Autor: Manfred Schartl, ME Mathers, E. Elizabeth Patton

Publikováno v: The Zebrafish: Disease Models and Chemical Screens
Methods in Cell Biology

Melanoma is the most deadly form of skin cancer and incidence continues to rise rapidly (Gray-Schopfer et al., 2007). Melanoma develops from melanocytes, the pigmented cells that color our skin, hair, and eyes. Fish also have melanocytes, among other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27f1f58ed0a4fa10baece79c41854c3

Application of transcript profiling in formalin-fixed paraffin-embedded diagnostic prostate cancer needle biopsies

Autor: Vincent J. Gnanapragasam, Steven Darby, Craig N. Robson, ME Mathers, Kieran O’Toole, Kanagasabai Sahadevan, Talal Jabbar, Lynsey Rogerson, Hing Y. Leung

Publikováno v: BJU International. 102:364-370

OBJECTIVE To investigate the feasibility of transcript profiling in diagnostic formalin-fixed and paraffin-embedded (FFPE) biopsies for prostate cancer. MATERIALS AND METHODS Laser-capture microdissection (LCM) was used to microdissect glandular epit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89f0c530ea58cc7ab9c5a9c14def77b
https://doi.org/10.1111/j.1464-410x.2008.07627.x

How predictive is a cervical smear suggesting glandular neoplasia?

Autor: V. Wadehra, Sarah J. Johnson, ME Mathers

Publikováno v: Cytopathology. 13:83-91

How predictive is a cervical smear suggesting glandular neoplasia The prevalence of endocervical adenocarcinoma and its precursors has increased, in part due to increased diagnostic awareness of these lesions. To date, limited information has been pu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d13b15bad7595364e88f43466485997
https://doi.org/10.1046/j.1365-2303.2002.00387.x

Similar expression to FGF (Sef) inhibits fibroblast growth factor-induced tumourigenic behaviour in prostate cancer cells and is downregulated in aggressive clinical disease

Autor: Vincent J. Gnanapragasam, Tania Murphy, Steven Darby, Craig N. Robson, ME Mathers, Huw D. Thomas, Hing Y. Leung

Publikováno v: British Journal of Cancer

BACKGROUND: The fibroblast growth factor (FGF) axis is an important mitogenic stimulus in prostate carcinogenesis. We have previously reported that transcript level of human similar expression to FGF (hSef), a key regulator of this pathway, is downre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cfc6ea9688b994f923359763793cc8d
https://pubmed.ncbi.nlm.nih.gov/19888221