The increase of extracellular Ca2+ from physiological concentrations to hypercalcemia impairs sino-atrial automaticity

Autor: M. Baudot, E Torre, Isabelle Bidaud, ME Mangoni, Angelo G. Torrente, L. Fossier, P. Mesirca

Publikováno v: EP Europace. 23

Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): ESC FRM Lefoulon Delalande Aims To investigate whether extracellular hypercalcemia alters the conduction through L-type Ca2+ channels (LTCCs), impairing the pacemak

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4aabb34b03f33860049644e91bc5cdba
https://doi.org/10.1093/europace/euab116.567

Cholinergic regulation of cardiac pacemaker activity by l-type cav1.3 channels

Autor: Isabelle Bidaud, P. Mesirca, L. Talssi, ME Mangoni

Publikováno v: European Heart Journal. 41

Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Fondation Recherche Médicale Introduction The cholinergic regulation of heart rate (HR) is mediated by acetylcholine (ACh)-dependent activation of M2-receptors (M2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62e5a5d125c73f287870caf69d7804b
https://doi.org/10.1093/ehjci/ehaa946.3597

P1083Heart automaticity in mice lacking pacemaker L-type Cav1.3 and T-type Cav3.1 channels

Autor: ME Mangoni, S. Barrere-Lemaire, Joël Nargeot, Ag. Torrente, S. Laaraoui, Joerg Striessnig, P. Mesirca, M. Baudot, Hs. Shin, Julien Roussel, Isabelle Bidaud

Publikováno v: EP Europace. 19:iii239-iii240

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96eaaf3c08a79ac984527032f91dfc8a
https://doi.org/10.1093/ehjci/eux150.006

Computational modelling of mouse atrio ventricular node action potential and automaticity.

Autor: Bartolucci C; Computational Physiopathology Unit, Department of Electrical, Electronic and Information Engineering 'Guglielmo Marconi,', University of Bologna, Cesena, Italy., Mesirca P; Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France.; LabEx Ion Channels Science and Therapeutics (ICST), Montpellier, France., Ricci E; Computational Physiopathology Unit, Department of Electrical, Electronic and Information Engineering 'Guglielmo Marconi,', University of Bologna, Cesena, Italy., Sales-Bellés C; BSICoS group, I3A Institute, University of Zaragoza, IIS Aragón, Zaragoza, Spain., Torre E; Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France.; LabEx Ion Channels Science and Therapeutics (ICST), Montpellier, France., Louradour J; Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France.; LabEx Ion Channels Science and Therapeutics (ICST), Montpellier, France., Mangoni ME; Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France.; LabEx Ion Channels Science and Therapeutics (ICST), Montpellier, France., Severi S; Computational Physiopathology Unit, Department of Electrical, Electronic and Information Engineering 'Guglielmo Marconi,', University of Bologna, Cesena, Italy.

Publikováno v: The Journal of physiology [J Physiol] 2024 Oct; Vol. 602 (19), pp. 4821-4847. Date of Electronic Publication: 2024 Sep 13.

Cardiac GR Mediates the Diurnal Rhythm in Ventricular Arrhythmia Susceptibility.

Autor: Tikhomirov R; Division of Cardiovascular Sciences (R.T., C.A., S.A.O., M.S., S.Y., L.S., H.A.S., G.M.M., A.D.), The University of Manchester, United Kingdom.; Myocardial Function Section, National Heart and Lung Institute, Imperial College London, United Kingdom (R.T., M.S., A.D.)., Oakley RH; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health (R.H.O., J.L., L.R.W., D.R.G., J.A.C.)., Anderson C; Division of Cardiovascular Sciences (R.T., C.A., S.A.O., M.S., S.Y., L.S., H.A.S., G.M.M., A.D.), The University of Manchester, United Kingdom., Xiang Y; Department of Physics and Astronomy (Y.X., H.Z.), The University of Manchester, United Kingdom., Al-Othman S; Division of Cardiovascular Sciences (R.T., C.A., S.A.O., M.S., S.Y., L.S., H.A.S., G.M.M., A.D.), The University of Manchester, United Kingdom., Smith M; Division of Cardiovascular Sciences (R.T., C.A., S.A.O., M.S., S.Y., L.S., H.A.S., G.M.M., A.D.), The University of Manchester, United Kingdom.; Myocardial Function Section, National Heart and Lung Institute, Imperial College London, United Kingdom (R.T., M.S., A.D.)., Yaar S; Division of Cardiovascular Sciences (R.T., C.A., S.A.O., M.S., S.Y., L.S., H.A.S., G.M.M., A.D.), The University of Manchester, United Kingdom., Torre E; Institut de Génomique Fonctionnelle, Université de Montpellier, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), F-34094 Montpellier France (E.T., P.M., M.E.M.)., Li J; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health (R.H.O., J.L., L.R.W., D.R.G., J.A.C.)., Wilson LR; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health (R.H.O., J.L., L.R.W., D.R.G., J.A.C.)., Goulding DR; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health (R.H.O., J.L., L.R.W., D.R.G., J.A.C.)., Donaldson I; Bioinformatics Core Facility (I.D.), The University of Manchester, United Kingdom., Harno E; Division of Diabetes, Endocrinology and Gastroenterology (E.H.), The University of Manchester, United Kingdom., Soattin L; Division of Cardiovascular Sciences (R.T., C.A., S.A.O., M.S., S.Y., L.S., H.A.S., G.M.M., A.D.), The University of Manchester, United Kingdom., Shiels HA; Division of Cardiovascular Sciences (R.T., C.A., S.A.O., M.S., S.Y., L.S., H.A.S., G.M.M., A.D.), The University of Manchester, United Kingdom., Morris GM; Division of Cardiovascular Sciences (R.T., C.A., S.A.O., M.S., S.Y., L.S., H.A.S., G.M.M., A.D.), The University of Manchester, United Kingdom.; Department of Cardiology, John Hunter Hospital, Newcastle, NSW, Australia (G.M.M.)., Zhang H; Department of Physics and Astronomy (Y.X., H.Z.), The University of Manchester, United Kingdom., Boyett MR; Faculty of Life Sciences, University of Bradford, United Kingdom (M.R.B.)., Cidlowski JA; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health (R.H.O., J.L., L.R.W., D.R.G., J.A.C.)., Mesirca P; Institut de Génomique Fonctionnelle, Université de Montpellier, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), F-34094 Montpellier France (E.T., P.M., M.E.M.)., Mangoni ME; Institut de Génomique Fonctionnelle, Université de Montpellier, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), F-34094 Montpellier France (E.T., P.M., M.E.M.)., D'Souza A; Division of Cardiovascular Sciences (R.T., C.A., S.A.O., M.S., S.Y., L.S., H.A.S., G.M.M., A.D.), The University of Manchester, United Kingdom.; Myocardial Function Section, National Heart and Lung Institute, Imperial College London, United Kingdom (R.T., M.S., A.D.).

Publikováno v: Circulation research [Circ Res] 2024 May 10; Vol. 134 (10), pp. 1306-1326. Date of Electronic Publication: 2024 Mar 27.