Loss of mDia1 and Fhod1 impacts platelet formation but not platelet function

Autor: Malou Zuidscherwoude, Elizabeth J. Haining, Victoria A. Simms, Stephanie Watson, Beata Grygielska, Alex T. Hardy, Andrea Bacon, Stephen P. Watson, Steven G. Thomas

Publikováno v: Platelets, Vol 32, Iss 8, Pp 1051-1062 (2021)

An organized and dynamic cytoskeleton is required for platelet formation and function. Formins are a large family of actin regulatory proteins which are also able to regulate microtubule dynamics. There are four formin family members expressed in hum

Externí odkaz: https://doaj.org/article/f7774f7cf129439b96883ed303eb513a

Inhibition of Sema4D/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy

Autor: Jie‐hong Wu, Ya‐nan Li, An‐qi Chen, Can‐dong Hong, Chun‐lin Zhang, Hai‐ling Wang, Yi‐fan Zhou, Peng‐Cheng Li, Yong Wang, Ling Mao, Yuan‐peng Xia, Quan‐wei He, Hui‐juan Jin, Zhen‐yu Yue, Bo Hu

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 2, Pp 1-23 (2020)

Abstract Diabetic retinopathy (DR) is a common complication of diabetes and leads to blindness. Anti‐VEGF is a primary treatment for DR. Its therapeutic effect is limited in non‐ or poor responders despite frequent injections. By performing a com

Externí odkaz: https://doaj.org/article/14c29eb98628469881203dfdcc387171

Mammalian Diaphanous 1 Mediates a Pathway for E-cadherin to Stabilize Epithelial Barriers through Junctional Contractility

Autor: Bipul R. Acharya, Selwin K. Wu, Zi Zhao Lieu, Robert G. Parton, Stephan W. Grill, Alexander D. Bershadsky, Guillermo A. Gomez, Alpha S. Yap

Publikováno v: Cell Reports, Vol 18, Iss 12, Pp 2854-2867 (2017)

Formins are a diverse class of actin regulators that influence filament dynamics and organization. Several formins have been identified at epithelial adherens junctions, but their functional impact remains incompletely understood. Here, we tested the

Externí odkaz: https://doaj.org/article/78266f0bc89a48699a31cb4997d97b48

Formin Activity and mDia1 Contribute to Maintain Axon Initial Segment Composition and Structure

Autor: Juan José Garrido, Pablo Mendez, Michaël Russier, Diana Retana, Norah Boumedine-Guignon, Wei Zhang, Beatriz Achón, Dominique Debanne, Maria Ciorraga

Publikováno v: Molecular Neurobiology
Molecular Neurobiology, 2021, ⟨10.1007/s12035-021-02531-6⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecular Neurobiology, Humana Press, 2021, ⟨10.1007/s12035-021-02531-6⟩

The axon initial segment (AIS) is essential for maintaining neuronal polarity, modulating protein transport into the axon, and action potential generation. These functions are supported by a distinctive actin and microtubule cytoskeleton that control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48fd22dac612831af9667dacc1b1546
https://doi.org/10.1007/s12035-021-02531-6

The Formin mDia1 Regulates Acute Lymphoblastic Leukemia Engraftment, Migration, and Progression in vivo

Autor: Scott B. Thompson, Eric J. Wigton, Sai Harsha Krovi, Jeffrey W. Chung, Robert A. Long, Jordan Jacobelli

Publikováno v: Frontiers in Oncology, Vol 8 (2018)

Leukemias typically arise in the bone marrow and then spread to the blood and into other tissues. To disseminate into tissues, leukemia cells migrate into the blood stream and then exit the circulation by migrating across vascular endothelial barrier

Externí odkaz: https://doaj.org/article/afc9c01cb6db49a2b593407fb3cd88a6