Výsledky vyhledávání - "MDR, multidrug resistance"

Akademický článek

Antibiotic use during coronavirus disease 2019 intensive care unit shape multidrug resistance bacteriuria: A Swedish longitudinal prospective study

Autor: Philip A. Karlsson, Julia Pärssinen, Erik A. Danielsson, Nikos Fatsis-Kavalopoulos, Robert Frithiof, Michael Hultström, Miklos Lipcsey, Josef D. Järhult, Helen Wang

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

ObjectivesHigh frequency of antimicrobial prescription and the nature of prolonged illness in COVID-19 increases risk for complicated bacteriuria and antibiotic resistance. We investigated risk factors for bacteriuria in the ICU and the correlation b

Externí odkaz: https://doaj.org/article/c9865ec7fff7459e8cc2ebde1bd7675b

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Akademický článek

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Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

Autor: Kenneth K.W. To, Jiang Ma, Stella Chai, Chunyuan Zhang, Chun Yin, Sheng Yao, Xu Wu, Thomas Efferth, Yang Ye, Onat Kadioglu, Ge Lin

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1885-1902 (2021)

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10ca45cdbb87dcf2ef29e5865d5f864
https://doi.org/10.1016/j.apsb.2020.12.021

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Akademický článek

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Recent advances in drug delivery systems for targeting cancer stem cells

Autor: Zhonggao Gao, Wei Huang, Hongxia Duan, Yanhong Liu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 55-70 (2021)
Acta Pharmaceutica Sinica. B

Cancer stem cells (CSCs) are a subpopulation of cancer cells with functions similar to those of normal stem cells. Although few in number, they are capable of self-renewal, unlimited proliferation, and multi-directional differentiation potential. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa624bee1b295d3b2a8ea11ea5504c8
http://www.sciencedirect.com/science/article/pii/S2211383520307322

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Scaffold fragmentation and substructure hopping reveal potential, robustness, and limits of computer-aided pattern analysis (C@PA)

Autor: Vigneshwaran Namasivayam, Jens Pahnke, Katja Silbermann, Michael Wiese, Sven Marcel Stefan

Publikováno v: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3269-3283 (2021)

Graphical abstract
Highlights • Exploratory changes in substructure patterns are well tolerated by C@PA. • Extended positive substructures support prediction capability. • Increased biological hit rate of 40% for multitarget pan-ABC transp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40715d0bceb0276ecc21ab6730bd845
https://doi.org/10.1016/j.csbj.2021.05.018

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Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer

Autor: Wing-Kee Lee, Michelle Maaß, Amy Quach, Nataliya Poscic, Holly Prangley, Erin-Claire Pallott, Jiyoon L. Kim, Jason S. Pierce, Besim Ogretmen, Anthony H. Futerman, Frank Thévenod

Publikováno v: The Journal of Biological Chemistry

Oncogenic multidrug resistance (MDR) is commonly intrinsic to renal cancer based on the physiological expression of detoxification transporters, particularly ABCB1, thus hampering chemotherapy. ABCB1 activity is directly dependent on its lipid microe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1819640a96f5d4d5386b5634e205d7
http://europepmc.org/articles/PMC8804196

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Correlation of inflammatory cytokines on corrected QT interval in rifampicin-resistant tuberculosis patients

Autor: Soedarsono, Nadya Luthfah, Winariani Koesoemoprodjo, Johanes Nugroho Eko Putranto, Ni Made Mertaniasih, Budi Suprapti, Aryani Prawita Sari, Tutik Kusmiati

Publikováno v: Annals of Medicine and Surgery

Background The cases of Rifampicin-Resistant Tuberculosis (RR-TB) in our country have increased every year and RR-TB deaths are thought to be caused by prolongation of the QTc interval due to side effects of anti-tuberculosis drugs. Thus, cytokines a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf672c153e3cc49824d5c3016c7fb17
http://europepmc.org/articles/PMC8452756

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Rociletinib (CO-1686) enhanced the efficacy of chemotherapeutic agents in ABCG2-overexpressing cancer cells in vitro and in vivo

Autor: Fanpu Zeng, Qian Han, Hong Zhang, Fang Wang, Zhen Chen, Zongheng Zheng, Kenneth K.W. To, Liwu Fu

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 5, Pp 799-811 (2020)

Overexpression of adenosine triphosphate (ATP)-binding cassette subfamily G member 2 (ABCG2) in cancer cells is known to cause multidrug resistance (MDR), which severely limits the clinical efficacy of chemotherapy. Currently, there is no FDA-approve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c640b876016d2964b38275e93078575
http://europepmc.org/articles/PMC7280144

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