Zobrazeno 1 - 10
of 168
pro vyhledávání: '"MDM2 protein"'
Akademický článek
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Autor:
Sabrina Taliani, Federico Da Settimo, Claudia Martini, Sonia Laneri, Ettore Novellino, Giovanni Greco
Publikováno v:
Molecules, Vol 25, Iss 10, p 2331 (2020)
Several indole derivatives have been disclosed by our research groups that have been collaborating for nearly 25 years. The results of our investigations led to a variety of molecules binding selectively to different pharmacological targets, specific
Externí odkaz:
https://doaj.org/article/17d219ede2874b3a800167781a126827
Akademický článek
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Publikováno v:
International Journal of Pharmaceutical Chemistry and Analysis. 8:41-44
MDM2 inhibitors class of anti-neoplastic drugs has been evolve after the successful discovery of the nutlins and other potent inhibitors. MDM2 inhibitors can specifically target the tumour cells in the body, by selectively reactivating the inhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7c03a058bb1ad48a6a4c67eaa7c8f74
https://doi.org/10.18231/j.ijpca.2021.009
https://doi.org/10.18231/j.ijpca.2021.009
Publikováno v:
Indian Journal of Pathology and Microbiology, Vol 57, Iss 4, Pp 558-563 (2014)
Context: Well-differentiated liposarcoma (WDLPS) is the most common type of liposarcoma and sometimes can be difficult to distinguish from large lipoma due to the similar morphology. Aims: This study proposed to evaluate the expression and amplificat
Externí odkaz:
https://doaj.org/article/e2a8fc6a78e74d578291f9307e5b1191
Autor:
Yutaka Fujiwara, Sakura Sakajiri, Takafumi Koyama, Junichi Tomomatsu, Shunji Takahashi, Yasuyuki Kakurai, Toshio Shimizu, Noboru Yamamoto, Kenji Nakano, Masaya Tachibana, Tomonari Yamashita, Mariko Ogura
Publikováno v:
Cancer Science
Milademetan (DS‐3032, RAIN‐32) is an orally available mouse double minute 2 (MDM2) antagonist with potential antineoplastic activity owing to increase in p53 activity through interruption of the MDM2‐p53 interaction. This phase I, dose‐escala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6cfb4209093de6d2e14c52661ffed94
http://europepmc.org/articles/PMC8177775
http://europepmc.org/articles/PMC8177775
Akademický článek
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Publikováno v:
Medicinal Chemistry Research. 29:1105-1121
The potentiation of p53 activity through inhibition of its negative regulator MDM2 is an attractive strategy for anticancer therapy. Much progress has been made in the last decade in a diverse range of areas related to p53 and MDM2. This review focus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c51b161069ee042c450d2fa62b6f9928
https://doi.org/10.1007/s00044-020-02574-9
https://doi.org/10.1007/s00044-020-02574-9
Publikováno v:
New Journal of Chemistry. 44:19174-19178
Cyclic peptides have become a powerful modality in drug development. Naturally isolated cyclic peptides such as phakellistatins have been found to have broad-spectrum bioactivity. In this paper, we have prepared an analog of phakellistatin 18, and tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::643cd21e27a3b74d5833193a147ee00b
https://doi.org/10.1039/d0nj03005h
https://doi.org/10.1039/d0nj03005h
Autor:
Maria da Conceição Andrade de Freitas, Luciana Maria Pedreira Ramalho, Flávia Caló Aquino Xavier, André Luis Gomes Moreira, Sílvia Regina Almeida Reis
Publikováno v:
Journal of Applied Oral Science, Vol 16, Iss 6, Pp 414-419 (2008)
Actinic cheilitis is a potentially malignant lip lesion caused by excessive and prolonged exposure to ultraviolet radiation, which can lead to histomorphological alterations indicative of abnormal cell differentiation. In this pathology, varying degr
Externí odkaz:
https://doaj.org/article/7edc6c26db8a4b40aa79cc7059db616b