Zobrazeno 1 - 10
of 206
pro vyhledávání: '"MDM2 amplification"'
Autor:
Ann-Katharina Becker, Behrus Puladi, Kunpeng Xie, Angela Cassataro, Rebekka Götzl, Frank Hölzle, Justus P. Beier, Ruth Knüchel-Clarke, Till Braunschweig
Publikováno v:
World Journal of Surgical Oncology, Vol 22, Iss 1, Pp 1-10 (2024)
Abstract Background Liposarcomas are among the most common mesenchymal malignancies. However, the therapeutic options are still very limited and so far, targeted therapies had not yet been established. Immunotherapy, which has been a breakthrough in
Externí odkaz:
https://doaj.org/article/c2107f0aff2548f4abc4d7f7832de02c
Autor:
Akihiro Nishiyama, Shigeki Sato, Hiroyuki Sakaguchi, Hiroshi Kotani, Kaname Yamashita, Koushiro Ohtsubo, Keishi Mizuguchi, Hiroko Ikeda, Kenji Iino, Hirofumi Takemura, Shinji Takeuchi
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
In the realm of rare cardiac tumors, intimal sarcoma presents a formidable challenge, often requiring innovative treatment approaches. This case report presents a unique instance of primary intimal sarcoma in the left atrium, underscoring the critica
Externí odkaz:
https://doaj.org/article/5b28db188c8a4b39872e162ed79f8cf7
Akademický článek
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Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Liposarcomas originating in the urinary bladder are extremely rare. Only six cases of bladder liposarcoma have been reported, and all have been described as myxoid liposarcomas. Notably, none of the patients underwent molecular testing. Here, we repo
Externí odkaz:
https://doaj.org/article/eba28d3a4fe54799a1119011c3bfb210
Akademický článek
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Autor:
Mitsuko Akaihata, Ikuko Takahashi, Yuko Kakuda, Takuya Kawata, Takashi Mukaigawa, Testuro Onitsuka, Shigeyuki Murayama, Yuji Ishida
Publikováno v:
Cancer Reports, Vol 6, Iss 2, Pp n/a-n/a (2023)
Abstract Background Murine double minute 2 (MDM2) is an oncogene that inhibits p53, leading to decreased apoptosis. Sarcomas showing MDM2 amplification are rare among pediatric patients. Case A 14‐year‐old boy presented with pleomorphic sarcoma o
Externí odkaz:
https://doaj.org/article/be3d1543db384b7c9767bf721cd030d8
Autor:
Bruno Almeida Costa, Victor Zibara, Vasundhara Singh, Omid Hamid, Sonal Gandhi, Andrea P. Moy, Allison S. Betof Warner
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Despite recent advances in treatment and surveillance, metastatic melanoma still carries a poor prognosis. Large/giant congenital melanocytic nevi (CMNs) constitute a known risk factor for the condition, with the greatest risk for malignant transform
Externí odkaz:
https://doaj.org/article/f8c6fb8e829a498090d06bef6cf92499
Akademický článek
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Publikováno v:
Human Pathology Reports, Vol 28, Iss , Pp 300639- (2022)
Extraskeletal osteosarcoma (EOS) is a sarcoma primary to soft tissue that produces tumor osteoid or bone (mineralized osteoid). It is rare, occurs generally in middle-aged to older adults in the extremities, and typically is histologically high grade
Externí odkaz:
https://doaj.org/article/2654b8d13c534ba5aee7ff6670d16791
Publikováno v:
Molecular Medicine, Vol 26, Iss 1, Pp 1-9 (2020)
Abstract Introduction Targeted therapy for NSCLC is rapidly evolving. EGFR-TKIs benefit NSCLC patients with sensitive EGFR mutations and significantly prolong survival. However, 20–30% of patients demonstrate primary resistance to EGFR-TKIs, which
Externí odkaz:
https://doaj.org/article/4baec2a3a5194a179027a86186116132