Doppel and PrPC co-immunoprecipitate in detergent-resistant membrane domains of epithelial FRT cells

Autor: Chiara Zurzolo, Maddalena Costanzo, Alessandro Negro, Vincenza Campana, Daniela Sarnataro, M. Catia Sorgato, Anna Caputo

Publikováno v: Biochemical Journal
Biochemical Journal, 2010, 425 (2), pp.341-51. ⟨10.1042/BJ20091050⟩
Biochemical Journal, Portland Press, 2010, 425 (2), pp.341-51. ⟨10.1042/BJ20091050⟩

International audience; Dpl (doppel) is a paralogue of the PrPC (cellular prion protein), whose misfolded conformer (the scrapie prion protein, PrPSc) is responsible for the onset of TSEs (transmissible spongiform encephalopathies) or prion diseases.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b535cf11e1441f046e7235fd030d365
https://doi.org/10.1042/bj20091050