Ca2+- associated triphasic pH changes in mitochondria during brown adipocyte activation

Autor: Madoka Suzuki, Rókus Kriszt, Michael Raghunath, Yu-Hua Tseng, Tetsuya Kitaguchi, Yanyan Hou

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 8, Pp 797-808 (2017)

Objective Brown adipocytes (BAs) are endowed with a high metabolic capacity for energy expenditure due to their high mitochondria content. While mitochondrial pH is dynamically regulated in response to stimulation and, in return, affects various meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc978cdf69b23cde7364b16b4949fd1
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100775204

Songorine promotes cardiac mitochondrial biogenesis via Nrf2 induction during sepsis

Autor: Ping Li, Baolin Liu, Meng-Ru Sun, Yi Li, Hua Yang, Hui-Min Zhu, Yu-Fan Feng, Yu-Chen Li, Xiao-Tian Liu

Publikováno v: Redox Biology
Redox Biology, Vol 38, Iss, Pp 101771-(2021)

Septic cardiomyopathy is characterized by impaired contractive function with mitochondrial dysregulation. Songorine is a typical active C20-diterpene alkaloid from the lateral root of Aconitum carmichaelii, which has been used for the treatment of he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccfbaa40881ff4417c6f9c6683fa36d6
https://doi.org/10.1016/j.redox.2020.101771

Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells

Autor: Edward M Haller, Kyle A. Bauckman, Nicholas Taran, Meera Nanjundan, Stephanie Rockfield, Abigail Ruiz-Rivera

Publikováno v: Biochemical Journal

The role of iron in the development of cancer remains unclear. We previously reported that iron reduces cell survival in a Ras/mitogen-activated protein kinase (MAPK)-dependent manner in ovarian cells; however, the underlying downstream pathway leadi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d912b4bab67cb0d3697e524c24559c20
http://europepmc.org/articles/PMC4338747

Letter in response to 'the role of succinate and ROS in reperfusion injury - A critical appraisal' by Andrienko et al

Autor: Antonio Rodríguez-Sinovas, David Garcia-Dorado, Marisol Ruiz-Meana, Ignasi Barba

Publikováno v: Journal of Molecular and Cellular Cardiology

We critically assess the proposal that succinate-fuelled reverse electron flow (REF) drives mitochondrial matrix superoxide production from Complex I early in reperfusion, thus acting as a key mediator of ischemia/reperfusion (IR) injury. Real-time s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634c2fd43b4e26a7f7a1dfc2fc12acd4
https://pubmed.ncbi.nlm.nih.gov/28689004

Ca ²⁺ -associated triphasic pH changes in mitochondria during brown adipocyte activation.

Autor: Hou Y; WASEDA Bioscience Research Institute in Singapore (WABIOS), 11 Biopolis Way, #05-02 Helios, Singapore 138667, Singapore., Kitaguchi T; WASEDA Bioscience Research Institute in Singapore (WABIOS), 11 Biopolis Way, #05-02 Helios, Singapore 138667, Singapore; Comprehensive Research Organization, Waseda University, Tokyo, 162-0041, Japan., Kriszt R; Department of Biomedical Engineering, National University of Singapore, 117583, Singapore; NUS Tissue Engineering Program, Life Sciences Institute, National University of Singapore, 117510, Singapore; Graduate School for Integrative Sciences and Engineering (NGS), National University of Singapore, 117456, Singapore., Tseng YH; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA., Raghunath M; Department of Biomedical Engineering, National University of Singapore, 117583, Singapore; NUS Tissue Engineering Program, Life Sciences Institute, National University of Singapore, 117510, Singapore; Department of Biochemistry, Yong Loo Ling School of Medicine, National University of Singapore, 117597, Singapore., Suzuki M; WASEDA Bioscience Research Institute in Singapore (WABIOS), 11 Biopolis Way, #05-02 Helios, Singapore 138667, Singapore; Comprehensive Research Organization, Waseda University, Tokyo, 162-0041, Japan; PRESTO, Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan. Electronic address: suzu_mado@aoni.waseda.jp.

Publikováno v: Molecular metabolism [Mol Metab] 2017 May 31; Vol. 6 (8), pp. 797-808. Date of Electronic Publication: 2017 May 31 (Print Publication: 2017).