Zobrazeno 1 - 10
of 219
pro vyhledávání: '"MCM Protein"'
Akademický článek
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Autor:
François-Michel Boisvert, Alyson McKenna, Dominique Jean, Simon Blais-Brochu, Anaïs Chauvin, Dominique Lévesque, Romain Drissi
Publikováno v:
Cell Cycle
DNA replication during S phase involves thousands of replication forks that must be coordinated to ensure that every DNA section is replicated only once. The minichromosome maintenance proteins, MCM2 to MCM7, form a heteromeric DNA helicase required
Autor:
Tahani M. Almeleebia, Mohammed Asiri, Munazzah Tasleem, Mohd Saeed, Kholoud M. Alshahrani, Najla A. Alshahrani, Arshiya Akeel, Mohammad Y. Alshahrani, Irfan Ahmad, Nadiyah M. Alabdallah
Publikováno v:
Molecules
Volume 26
Issue 19
Molecules, Vol 26, Iss 5878, p 5878 (2021)
Volume 26
Issue 19
Molecules, Vol 26, Iss 5878, p 5878 (2021)
Minichromosome maintenance complex component 7 (MCM7) is involved in replicative licensing and the synthesis of DNA, and its overexpression is a fascinating biomarker for various cancer types. There is currently no effective agent that can prevent th
Publikováno v:
Oncology Reports
The minichromosome maintenance (MCM) gene family plays an essential role in DNA replication and cell cycle progression. However, MCM gene expression has not been well‑studied in lung adenocarcinoma (LUAD). In the present study, the expression, prog
Akademický článek
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Autor:
Tanya Ivanova Stoyanova
Publikováno v:
Cancer Research. 81:1167-1167
Background: Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer that rarely develops de novo in primary tumors and is commonly acquired during the development of treatment resistance. NEPC is characterized by gain of neuroend
Autor:
Ningning Li, Philip Y. K. Yung, Hao Wu, Yuanliang Zhai, Bik Kwoon Tye, Ning Gao, Erchao Cheng
Publikováno v:
Nature Structural & Molecular Biology. 24:300-308
A high-resolution cryo-EM structure of the heptameric Cdt1–Mcm2–7 complex of the replicative helicase from budding yeast suggests a ‘spring-action’ DNA-unwinding mechanism. The minichromosome maintenance complex (MCM) hexameric complex (Mcm2
Publikováno v:
Plant Molecular Biology. 86:69-84
The MINICHROMOSOME MAINTENANCE 2-7 (MCM2-7) complex, a ring-shaped heterohexamer, unwinds the DNA double helix ahead of the other replication machinery. Although there is evidence that individual components might have other roles, the essential natur
Publikováno v:
Fish & Shellfish Immunology. 55:293-303
Minichromosome maintenance protein (MCM7) belongs to the MCM protein family and participates in the MCM complex by playing a role in the cell replication cycle and chromosome initiation of eukaryotes. Previously, we found that several genes, includin
Autor:
Jin Chuan Zhou, Abhay Kotecha, Ferdos Abid Ali, David Rueda, Hailey L. Gahlon, Julian Gannon, Alessandro Costa, Ludovic Renault
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications
Nature Communications, 7
Nature Communications
Nature Communications, 7
The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during the elongation step of eukaryotic genome duplication and this process depends on the MCM ATPase function. Whether CMG translocation occurs on single- or double-stranded DNA and how ATP hydrolysis d