Zobrazeno 1 - 10
of 517
pro vyhledávání: '"MBNL1"'
Autor:
Yingying Gong, Meilin Wei, Xiaopei Cao, Changliu Xu, Jiewen Jin, Ling Pei, Yanbing Li, Haipeng Xiao, Liting Wu
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-19 (2024)
Abstract Background Diabetes, a global epidemic, is the leading cause of mortality globally. The aim of this study is to get better understanding of pathophysiology of diabetes. Methods Palmitic acid (PA)-treated β-cells, db/db mice and high fat die
Externí odkaz:
https://doaj.org/article/dd360c6577a842159bec172353d5fa4a
Autor:
Xinyu Wan, Wenjie Shi, Lingjun Ma, Lexin Wang, Ran Zheng, Jinzhi He, Ye Wang, Xuan Li, Xiaoming Zha, Jue Wang, Lu Xu
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 5, Pp n/a-n/a (2024)
Abstract Background We explored the potential novel anticancer mechanisms of 25‐hydroxyvitamin D (25(OH)D), a vitamin D metabolite with antitumour effects in breast cancer. It is stable in serum and is used to assess vitamin D levels in clinical pr
Externí odkaz:
https://doaj.org/article/b38a78987b3e4e1a94742eb09655d80e
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity, Vol Volume 16, Pp 2105-2116 (2023)
Qiong Wang, Yanting Zhu, Qianlan Dong, Linping Zhang, Wei Zhang Kidney Disease and Dialysis Center, Shaanxi Provincial People’s Hospital, Xi’an City, Shaanxi, People’s Republic of ChinaCorrespondence: Wei Zhang, Kidney Disease and Dialysis Cent
Externí odkaz:
https://doaj.org/article/f916e5aa1f764bf4b9e34e1b23239948
Autor:
Najoua El Boujnouni, M. Leontien van der Bent, Marieke Willemse, Peter A.C. ’t Hoen, Roland Brock, Derick G. Wansink
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 622-636 (2023)
Antisense oligonucleotide (ASO) therapies for myotonic dystrophy type 1 (DM1) are based on elimination of transcripts containing an expanded repeat or inhibition of sequestration of RNA-binding proteins. This activity is achievable by both degradatio
Externí odkaz:
https://doaj.org/article/97e890b2b5784324b32954702b47d821
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-13 (2023)
Abstract Reduced brain volume including atrophy in grey and white matter is commonly seen in myotonic dystrophy type 1 (DM1). DM1 is caused by an expansion of CTG trinucleotide repeats in the 3’ untranslated region (UTR) of the Dystrophia Myotonica
Externí odkaz:
https://doaj.org/article/841ae7af52e04a8ca3550052a8d2e5dd
Autor:
Kun Huang, Dan-Dan Wang, Wen-Bao Hu, Wei-Qian Zeng, Xia Xu, Qiu-Xiang Li, Fang-Fang Bi, Huan Yang, Jian Qiu
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-10 (2022)
Abstract Background Myotonic dystrophy type 1 (DM1), one of the most common forms of adult-onset muscular dystrophy, is caused by abnormally expanded CTG repeats in the 3′ untranslated region of the DMPK gene. The CUG repeats transcribed from the e
Externí odkaz:
https://doaj.org/article/9908958568a04201bf93ea59e4e0e755
Autor:
Zuzanna Rogalska, Krzysztof Sobczak
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 438-448 (2022)
Muscleblind-like proteins (MBNLs) are RNA-binding proteins essential for the developmental regulation of various processes including alternative splicing. Their activity is misregulated in myotonic dystrophy type 1 (DM1), an incurable genetic, neuro-
Externí odkaz:
https://doaj.org/article/4897f94d296541b1b28ee73aa7cd46fe
Autor:
Hongwu Li, Ping Liu, Dapeng Li, Zixi Wang, Zhao Ding, Meng Zhou, Xu Chen, Manli Miao, Junli Ding, Wei Lin, Yehai Liu, Xiaojun Zha
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-21 (2022)
Abstract Background Aberrantly activated mammalian target of rapamycin complex 1 (mTORC1) plays a vital role in tumor angiogenesis, but its precise mechanisms are still unclear. Methods Micro-RNA-130b-3p (miR-130b-3p) expression in mTORC1-activated a
Externí odkaz:
https://doaj.org/article/525718db760342b299f203e95b0ea741
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Autor:
Estefanía Cerro-Herreros, Irene González-Martínez, Nerea Moreno, Jorge Espinosa-Espinosa, Juan M. Fernández-Costa, Anna Colom-Rodrigo, Sarah J. Overby, David Seoane-Miraz, Javier Poyatos-García, Juan J. Vilchez, Adolfo López de Munain, Miguel A. Varela, Matthew J. Wood, Manuel Pérez-Alonso, Beatriz Llamusí, Rubén Artero
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 174-191 (2021)
Myotonic dystrophy type 1 (DM1) is a rare neuromuscular disease caused by expansion of unstable CTG repeats in a non-coding region of the DMPK gene. CUG expansions in mutant DMPK transcripts sequester MBNL1 proteins in ribonuclear foci. Depletion of
Externí odkaz:
https://doaj.org/article/fcb1590ef3cd430fb37c123264dbacdc