Zobrazeno 1 - 10
of 48
pro vyhledávání: '"MB Reichel"'
Autor:
MB Reichel, F G Sarra, Robin R. Ali, P. Trittibach, S Estermann, E Tsiroukis, F C Schlichtenbrede, P J Luthert, G.–M. Sarra
Publikováno v:
Ophthalmic Research. 37:72-82
Background: In hereditary retinal degeneration, microglia cells become activated, migrate through the outer nuclear layer (ONL) and accumulate in the subretinal space. Although this inflammatory process is not likely to be responsible for the onset o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5226b94e357a3bb3deafe0a03f8619a7
https://doi.org/10.1159/000084248
https://doi.org/10.1159/000084248
Autor:
MB Reichel, G.–M. Sarra, Mahesh de Alwis, Sascha Fauser, Peter M. G. Munro, Adrian J. Thrasher, James W B Bainbridge, Shomi S. Bhattacharya, Christine Kinnon, Robin R. Ali, C Stephens, David M. Hunt
Publikováno v:
Nature Genetics. 25:306-310
The gene Prph2 encodes a photoreceptor-specific membrane glycoprotein1, peripherin-2 (also known as peripherin/rds), which is inserted into the rims of photoreceptor outer segment discs in a complex with rom-1 (ref. 2). The complex is necessary for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f75090e4c4c80dccecf7a797a594f8
https://doi.org/10.1038/77068
https://doi.org/10.1038/77068
Autor:
C Stephens, Adrian J. Thrasher, David Baker, Shomi S. Bhattacharya, Robin R. Ali, David M. Hunt, Andrew P. Byrnes, MB Reichel
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
5 páginas, 4 figuras.-- et al.
There is growing interest in gene delivery to the eye in order to develop gene therapy for the many ocular disorders which may be amenable to this approach. To date, recombinant adenoviruses (AV) have been the mai
There is growing interest in gene delivery to the eye in order to develop gene therapy for the many ocular disorders which may be amenable to this approach. To date, recombinant adenoviruses (AV) have been the mai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dab2c8c2b021f7b115ab5548904bbe6
https://doi.org/10.1038/sj.gt.3300761
https://doi.org/10.1038/sj.gt.3300761
Autor:
Cheryl Y. Gregory, Kevin Evans, MB Reichel, David M. Hunt, Fred W. Fitzke, Rosemary E. Kelsell, Joseph Fan, Anthony T. Moore, Alan C. Bird
Publikováno v:
British Journal of Ophthalmology. 82:1162-1168
AIMS—To document the phenotype of an autosomal dominant macular dystrophy diagnosed as having North Carolina macular dystrophy (NCMD) in this British family, and to verify that the disease locus corresponds with that of MCDR1 on chromosome 6q. METH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad245e6eed7a40ac610455a50e06001f
https://doi.org/10.1136/bjo.82.10.1162
https://doi.org/10.1136/bjo.82.10.1162
Publikováno v:
British Journal of Ophthalmology. 82:1072-1077
AIMS—To establish a simple model of conjunctival wound healing in the mouse eye. METHODS—4 week old BALB/c mouse eyes were studied over a 14 day period. Surgical procedure under general anaesthesia involved a blunt dissection of the conjunctiva p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998edc6ab34a2e89639f099dd343832c
https://doi.org/10.1136/bjo.82.9.1072
https://doi.org/10.1136/bjo.82.9.1072
Autor:
David M. Hunt, Adrian J. Thrasher, David Baker, Robin R. Ali, MB Reichel, Shomi S. Bhattacharya
Publikováno v:
Gene Therapy. 5:1038-1046
In order to investigate the immunological consequences of that the eye is not normally immune-privileged with respect gene transfer to the eye using viral vectors, adenovirus car- to viral vectors. Inflammatory cells were detected in the vitrying a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0569a6cb56d7b550d9a1fcb0760303ff
https://doi.org/10.1038/sj.gt.3300691
https://doi.org/10.1038/sj.gt.3300691
Autor:
Robin R. Ali, Philip J. Luthert, MB Reichel, Alan Richard Clarke, Shomi S. Bhattacharya, David M. Hunt, Fabiana d'Esposito
Publikováno v:
Cell Death & Differentiation. 5:156-162
High frequency of persistent hyperplastic primary vitreous and cataracts in p53-deficient mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c43973f1f451416c14f80ebb8ccc99c4
https://doi.org/10.1038/sj.cdd.4400326
https://doi.org/10.1038/sj.cdd.4400326
Autor:
Shomi S. Bhattacharya, Christine Kinnon, MB Reichel, David M. Hunt, Robin R. Ali, M De Alwis, Adrian J. Thrasher, Roland J. Levinsky, Naheed Kanuga
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
6 páginas, 5 figuras.-- et al.
Ocular gene transfer may provide a means for arresting the retinal degeneration characteristic of many inherited causes of blindness, including retinitis pigmentosa (RP). Previously, we have shown in immunodeficie
Ocular gene transfer may provide a means for arresting the retinal degeneration characteristic of many inherited causes of blindness, including retinitis pigmentosa (RP). Previously, we have shown in immunodeficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39cd404c7816954d5f599331c5e520a
http://hdl.handle.net/10261/40504
http://hdl.handle.net/10261/40504
Autor:
Annett Markwart, Peter Wiedemann, Andrea Tannapfel, MB Reichel, Alireza Mirmohammadsaegh, Anette Weber, Ulrich R. Hengge, Doris Urbanik, Christian Wittekind
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 83(12)
The v-raf murine sarcoma viral homolog B1 (BRAF) gene, one of the human isoforms of RAF, is activated by Ras, leading to cooperative effects in cells responsive to growth factor signals. Recently, somatic missense mutations of the BRAF gene have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75cae46b7c9be2b7b8a5489467e6f02
https://pubmed.ncbi.nlm.nih.gov/14691295
https://pubmed.ncbi.nlm.nih.gov/14691295
Autor:
S. S. Bhattacharya, Robin R. Ali, MB Reichel, Adrian J. Thrasher, James W B Bainbridge, David Baker
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
4 páginas, 3 figuras.-- et al.
[BACKGROUND/AIMS]: Retinal degenerations are a leading cause of blindness for which there are currently no effective treatments. This has stimulated interest in the investigation of gene therapy strategies for the
[BACKGROUND/AIMS]: Retinal degenerations are a leading cause of blindness for which there are currently no effective treatments. This has stimulated interest in the investigation of gene therapy strategies for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97bdb442e30f910f55a0a375f8a87307
http://hdl.handle.net/10261/40553
http://hdl.handle.net/10261/40553