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12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice.

Autor: Nargis T; Department of Medicine and the Kovler Diabetes Center, The Univeristy of Chicago, Chicago, United States of America., Muralidharan C; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, United States of America., Enriquez JR; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, United States of America., Wang JE; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, United States of America., Kaylan KB; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, United States of America., Chakraborty A; Department of Medicine and the Kovler Diabetes Center, The Univeristy of Chicago, Chicago, United States of America., Pratuangtham S; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, United States of America., Figatner K; Department of Medicine and the Kovler Diabetes Center, The Univeristy of Chicago, Chicago, United States of America., Nelson JB; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, United States of America., May SC; Department of Medicine and the Kovler Diabetes Center, The Univeristy of Chicago, Chicago, United States of America., Nadler JL; Department of Pharmacology, New York Medical College, Valhalla, United States of America., Boxer MB; Veralox Therapeutics, Frederick, United States of America., Maloney DJ; Veralox Therapeutics, Frederick, United States of America., Tersey SA; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, United States of America., Mirmira RG; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, United States of America.

Publikováno v: JCI insight [JCI Insight] 2024 Nov 12. Date of Electronic Publication: 2024 Nov 12.

Inhibition of the eukaryotic initiation factor-2α kinase PERK decreases risk of autoimmune diabetes in mice.

Autor: Muralidharan C; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, Illinois, USA., Huang F; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, Illinois, USA., Enriquez JR; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, Illinois, USA., Wang JE; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, Illinois, USA., Nelson JB; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, Illinois, USA., Nargis T; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, Illinois, USA., May SC; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, Illinois, USA., Chakraborty A; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, Illinois, USA., Figatner KT; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, Illinois, USA., Navitskaya S; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, Illinois, USA., Anderson CM; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, Illinois, USA., Calvo V; HiberCell Inc., New York, New York, USA., Surguladze D; HiberCell Inc., New York, New York, USA., Mulvihill MJ; HiberCell Inc., New York, New York, USA., Yi X; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium., Sarkar S; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Oakes SA; Department of Pathology, The University of Chicago, Chicago, Illinois, USA., Webb-Robertson BM; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Sims EK; Department of Pediatrics, Center for Diabetes and Metabolic Diseases, Wells Center for Pediatric Research, and., Staschke KA; Department of Biochemistry and Molecular Biology and the Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA., Eizirik DL; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium., Nakayasu ES; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Stokes ME; HiberCell Inc., New York, New York, USA., Tersey SA; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, Illinois, USA., Mirmira RG; Department of Medicine and the Kovler Diabetes Center, The University of Chicago, Chicago, Illinois, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Jun 18; Vol. 134 (16). Date of Electronic Publication: 2024 Jun 18.

Discordant Effects of Polyamine Depletion by DENSpm and DFMO on β-cell Cytokine Stress and Diabetes Outcomes in Mice.

Autor: Hammoud B; Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA., Nelson JB; Department of Medicine, The University of Chicago, Chicago, IL 60637, USA., May SC; Department of Medicine, The University of Chicago, Chicago, IL 60637, USA., Tersey SA; Department of Medicine, The University of Chicago, Chicago, IL 60637, USA., Mirmira RG; Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA.; Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.

Publikováno v: Endocrinology [Endocrinology] 2024 Jan 16; Vol. 165 (3).

Stress and human health in diabetes: A report from the 19 ^th Chicago Biomedical Consortium symposium.

Autor: Mirmira RG; Department of Medicine, Kovler Diabetes Center, The University of Chicago, Chicago, IL, USA., Kulkarni RN; Department of Medicine, Islet Cell and Regenerative Biology, Joslin Diabetes Center, Beth Israel Deaconess Medical Center, Harvard Stem Cell Institute, Boston, MA, USA., Xu P; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA., Drossos T; Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA., Varady K; Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA., Knutson KL; Department of Neurology, Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Reutrakul S; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA., Martyn-Nemeth P; Department of Biobehavioral Nursing Science, University of Illinois Chicago College of Nursing, Chicago, IL, USA., Sargis RM; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.; Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, Jesse Brown VA Medical Center, Chicago, IL, USA., Wallia A; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Tuchman AM; Department of History, Vanderbilt University, Nashville, TN, USA., Weissberg-Benchell J; Department of Psychiatry and Behavioral Sciences, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Danielson KK; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA., Oakes SA; Department of Pathology, The University of Chicago, Chicago, IL, USA., Thomas CC; Department of Medicine, Kovler Diabetes Center, The University of Chicago, Chicago, IL, USA., Layden BT; Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, The University of Chicago, Chicago, IL, USA., May SC; Department of Medicine, Kovler Diabetes Center, The University of Chicago, Chicago, IL, USA., Burbea Hoffmann M; Chicago Biomedical Consortium, Evanston, IL, USA., Gatta E; Chicago Biomedical Consortium, Evanston, IL, USA., Solway J; Department of Medicine, University of Chicago, Chicago, IL, USA., Philipson LH; Department of Medicine and Pediatrics, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, The University of Chicago, Chicago, IL, USA.

Publikováno v: Journal of clinical and translational science [J Clin Transl Sci] 2023 Nov 20; Vol. 7 (1), pp. e263. Date of Electronic Publication: 2023 Nov 20 (Print Publication: 2023).