Zobrazeno 1 - 10
of 940
pro vyhledávání: '"MAURO GIACCA"'
Autor:
Hye Yeon Choi, Yicheng Zhu, Xuyao Zhao, Simran Mehta, Juan Carlos Hernandez, Jae-Jin Lee, Yi Kou, Risa Machida, Mauro Giacca, Giannino Del Sal, Ratna Ray, Hyungjin Eoh, Stanley M. Tahara, Lin Chen, Hidekazu Tsukamoto, Keigo Machida
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 2, Pp 461-477 (2024)
Abstract The P53-destabilizing TBC1D15-NOTCH protein interaction promotes self-renewal of tumor-initiating stem-like cells (TICs); however, the mechanisms governing the regulation of this pathway have not been fully elucidated. Here, we show that TBC
Externí odkaz:
https://doaj.org/article/cce91a31632d430a830e45249520ef25
Autor:
Ambra Cappelletto, Edoardo Alfì, Nina Volf, Thi Van Anh Vu, Francesca Bortolotti, Giulio Ciucci, Simone Vodret, Marco Fantuz, Martina Perin, Andrea Colliva, Giacomo Rozzi, Matilde Rossi, Giulia Ruozi, Lorena Zentilin, Roman Vuerich, Daniele Borin, Romano Lapasin, Silvano Piazza, Mattia Chiesa, Daniela Lorizio, Luca Triboli, Sandeep Kumar, Gaia Morello, Claudio Tripodo, Maurizio Pinamonti, Giulia Maria Piperno, Federica Benvenuti, Alessandra Rustighi, Hanjoong Jo, Stefano Piccolo, Giannino Del Sal, Alessandro Carrer, Mauro Giacca, Serena Zacchigna
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-14 (2024)
Abstract Background New drugs to tackle the next pathway or mutation fueling cancer are constantly proposed, but 97% of them are doomed to fail in clinical trials, largely because they are identified by cellular or in silico screens that cannot predi
Externí odkaz:
https://doaj.org/article/a789156b8a0b44008d091dcfb970d332
Autor:
Hye Yeon Choi, Yicheng Zhu, Xuyao Zhao, Simran Mehta, Juan Carlos Hernandez, Jae-Jin Lee, Yi Kou, Risa Machida, Mauro Giacca, Giannino Del Sal, Ratna Ray, Hyungjin Eoh, Stanley M. Tahara, Lin Chen, Hidekazu Tsukamoto, Keigo Machida
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 10, Pp 2323-2323 (2024)
Externí odkaz:
https://doaj.org/article/15ad0b71720f4c6c94a3eda7ed45a7d3
Autor:
Sonal Joshi, Lucía López, Luciano Gastón Morosi, Roberto Amadio, Manendra Pachauri, Marco Bestagno, Ironya Paul Ogar, Mauro Giacca, Giulia Maria Piperno, Daan Vorselen, Federica Benvenuti
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114096- (2024)
Summary: Receptors controlling the cross-presentation of tumor antigens by macrophage subsets in cancer tissues are poorly explored. Here, we show that TIM4+ large peritoneal macrophages efficiently capture and cross-present tumor-associated antigens
Externí odkaz:
https://doaj.org/article/c2dde8a380ab4786a23705a24951b4bc
Autor:
Sara G. Romeo, Ilaria Secco, Edoardo Schneider, Christina M. Reumiller, Celio X. C. Santos, Anna Zoccarato, Vishal Musale, Aman Pooni, Xiaoke Yin, Konstantinos Theofilatos, Silvia Cellone Trevelin, Lingfang Zeng, Giovanni E. Mann, Varun Pathak, Kevin Harkin, Alan W. Stitt, Reinhold J. Medina, Andriana Margariti, Manuel Mayr, Ajay M. Shah, Mauro Giacca, Anna Zampetaki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The microvasculature plays a key role in tissue perfusion and exchange of gases and metabolites. In this study we use human blood vessel organoids (BVOs) as a model of the microvasculature. BVOs fully recapitulate key features of the human m
Externí odkaz:
https://doaj.org/article/353954422197417aa51e7b271e88c1e2
Autor:
Konstantina Amoiradaki, BSc, Mateusz Tomczyk, PhD, Xiaoying Wang, Gastao Lima Da Cruz, Carlos Velasco, PhD, Lorena Zentilin, PhD, Francesca Bortolotti, PhD, Claudia Prieto, PhD, René Botnar, PhD, Mauro Giacca, PhD, Alkystis Phinikaridou
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 26, Iss , Pp 100839- (2024)
Externí odkaz:
https://doaj.org/article/4569904326b540359430fff30428718a
Autor:
Gerd Heusch, Ioanna Andreadou, Robert Bell, Edoardo Bertero, Hans-Erik Botker, Sean M. Davidson, James Downey, Philip Eaton, Peter Ferdinandy, Bernard J. Gersh, Mauro Giacca, Derek J. Hausenloy, Borja Ibanez, Thomas Krieg, Christoph Maack, Rainer Schulz, Frank Sellke, Ajay M. Shah, Holger Thiele, Derek M. Yellon, Fabio Di Lisa
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102894- (2023)
The present review summarizes the beneficial and detrimental roles of reactive oxygen species in myocardial ischemia/reperfusion injury and cardioprotection. In the first part, the continued need for cardioprotection beyond that by rapid reperfusion
Externí odkaz:
https://doaj.org/article/0fa5d92cdebd454588eef18a999eac76
Autor:
Paolo Carai, Giulia Ruozi, Alexandra Paye, Yannick Debing, Francesca Bortolotti, Julie Lecomte, Lorena Zentilin, Elizabeth A. V. Jones, Mauro Giacca, Stephane Heymans
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Viral myocarditis (VM) is an important cause of heart failure (HF) in children and adults. However, the molecular determinants involved in cardiac inflammation and cardiomyocyte necrosis remain poorly characterized, and cardioprotective mole
Externí odkaz:
https://doaj.org/article/b6c8a8bf701d4506ac78809b0f83b782
Autor:
Slobodan Vukicevic, Andrea Colliva, Vera Kufner, Valentina Martinelli, Silvia Moimas, Simone Vodret, Viktorija Rumenovic, Milan Milosevic, Boris Brkljacic, Diana Delic-Brkljacic, Ricardo Correa, Mauro Giacca, Manuel Maglione, Tatjana Bordukalo-Niksic, Ivo Dumic-Cule, Serena Zacchigna
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Here the authors show that a monoclonal antibody against a soluble isoform of Bone Morphogenetic Protein 1 prevents cardiac cell death, reducing fibrosis and preserving cardiac function after myocardial ischemia.
Externí odkaz:
https://doaj.org/article/107372050a2b47219731ca9d8eaea059
Autor:
Roberto Dinami, Luca Pompili, Eleonora Petti, Manuela Porru, Carmen D'Angelo, Serena Di Vito, Angela Rizzo, Virginia Campani, Giuseppe De Rosa, Alejandra Bruna, Violeta Serra, Miguel Mano, Mauro Giacca, Carlo Leonetti, Gennaro Ciliberto, Madalena Tarsounas, Antonella Stoppacciaro, Stefan Schoeftner, Annamaria Biroccio
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 1, Pp n/a-n/a (2023)
Abstract The telomeric repeat‐binding factor 2 (TRF2) is a telomere‐capping protein that plays a key role in the maintenance of telomere structure and function. It is highly expressed in different cancer types, and it contributes to cancer progre
Externí odkaz:
https://doaj.org/article/329d8d14529b400796d6b5c09e60a4e4