Zobrazeno 1 - 10
of 443
pro vyhledávání: '"MASSIMO TRUCCO"'
Autor:
Brett E. Phillips, Louise Lantier, Carl Engman, Yesica Garciafigueroa, Aatur Singhi, Massimo Trucco, Christos Mantzoros, David Wasserman, Nick Giannoukakis
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-15 (2022)
Abstract Background Liver pathology (LP) characteristic of non-alcoholic fatty acid disease (NAFLD)/non-alcoholic steatohepatitis (NASH) is a prevalent co-morbidity of type 2 diabetes (T2D). Accumulating evidence indicates that neutrophils driving in
Externí odkaz:
https://doaj.org/article/ab612ea663e24ad9bf187ea3930f8857
Autor:
Despoina Aslanoglou, Suzanne Bertera, Marta Sánchez-Soto, R. Benjamin Free, Jeongkyung Lee, Wei Zong, Xiangning Xue, Shristi Shrestha, Marcela Brissova, Ryan W. Logan, Claes B. Wollheim, Massimo Trucco, Vijay K. Yechoor, David R. Sibley, Rita Bottino, Zachary Freyberg
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central nervous system that also act in the pancreas as peripheral regulators of metabolism. Pancreatic catecholamine signaling has also been increasingly impl
Externí odkaz:
https://doaj.org/article/b9206d5d35df46e48ee2e0a5e574828b
Autor:
Suzanne Bertera, Michael F. Knoll, Carmela Knoll, Hidetaka Hara, Erin A. Kimbrel, Nickolas A. Kouris, Robert Lanza, Brett E. Philips, Yesica Garciafigueroa, Nick Giannoukakis, David K. C. Cooper, Massimo Trucco, Rita Bottino
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Islet transplantation can restore glycemic control in patients with type 1 diabetes. Using this procedure, the early stages of engraftment are often crucial to long-term islet function, and outcomes are not always successful. Numerous studies have sh
Externí odkaz:
https://doaj.org/article/c89e602512da4cb996df2f4edd9b2242
Autor:
Brett E. Phillips, Yesica Garciafigueroa, Carl Engman, Wen Liu, Yiwei Wang, Robert J. Lakomy, Wilson S. Meng, Massimo Trucco, Nick Giannoukakis
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Type 1 diabetes (T1D) is a disorder of impaired glucoregulation due to lymphocyte-driven pancreatic autoimmunity. Mobilizing dendritic cells (DC) in vivo to acquire tolerogenic activity is an attractive therapeutic approach as it results in multiple
Externí odkaz:
https://doaj.org/article/b7115775fd76459d90db58ac35351f4b
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
A growing body of evidence indicates that neutrophils are the first major leukocyte population accumulating inside the pancreas even before the onset of a lymphocytic-driven impairment of functional beta cells in type 1 diabetes mellitus (T1D). In hu
Externí odkaz:
https://doaj.org/article/1fbec8a461a243dba58e2b6e328be1a5
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Tolerogenic dendritic cells and T-regulatory cells are two immune cell populations with the potential to prevent the onset of clinical stage type 1 diabetes, and manage the beginning of underlying autoimmunity, at the time-at-onset and onwards. Initi
Externí odkaz:
https://doaj.org/article/0f25397e35ba4907a6e6a3fe471af28a
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Dendritic cells (DC) are important in the onset and severity of inflammatory bowel disease (IBD). Tolerogenic DC induce T-cells to become therapeutic Foxp3+ regulatory T-cells (Tregs). We therefore asked if experimental IBD could be prevented by admi
Externí odkaz:
https://doaj.org/article/a5c7d72f11f3424e8785a5bec1250959
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Tolerogenic dendritic cell (tDC)-based clinical trials for the treatment of autoimmune diseases are now a reality. Clinical trials are currently exploring the effectiveness of tDC to treat autoimmune diseases of type 1 diabetes mellitus, rheumatoid a
Externí odkaz:
https://doaj.org/article/0aa8ee82e3ab4d689feaf06483c963a6
Autor:
Phillip Lord, Rachel Spiering, Juan C. Aguillon, Amy E. Anderson, Silke Appel, Daniel Benitez-Ribas, Anja ten Brinke, Femke Broere, Nathalie Cools, Maria Cristina Cuturi, Julie Diboll, Edward K. Geissler, Nick Giannoukakis, Silvia Gregori, S. Marieke van Ham, Staci Lattimer, Lindsay Marshall, Rachel A. Harry, James A. Hutchinson, John D. Isaacs, Irma Joosten, Cees van Kooten, Ascension Lopez Diaz de Cerio, Tatjana Nikolic, Haluk Barbaros Oral, Ljiljana Sofronic-Milosavljevic, Thomas Ritter, Paloma Riquelme, Angus W. Thomson, Massimo Trucco, Marta Vives-Pi, Eva M. Martinez-Caceres, Catharien M.U. Hilkens
Publikováno v:
PeerJ, Vol 4, p e2300 (2016)
Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation. The methodologies for generating tolAPC va
Externí odkaz:
https://doaj.org/article/9ff191435bf7451cb77f534680bb43e6
Autor:
Ling-Jia Wang, Tatsuya Kin, Doug O'gorman, A. M. James Shapiro, Bashoo Naziruddin, Morihito Takita, Marlon F. Levy, Andrew M. Posselt, Gregory L. Szot, Omid Savari, Barbara Barbaro, James McGarrigle, Chun Chieh Yeh, Jose Oberholzer, Ji Lei, Tao Chen, Moh Lian, James F. Markmann, Alejandro Alvarez, Elina Linetsky, Camillo Ricordi, A. N. Balamurugan, Gopalakrishnan Loganathan, Joshua J. Wilhelm, Bernhard J. Hering, Rita Bottino, Massimo Trucco, Chengyang Liu, Zaw Min, Yanjing Li, Ali Naji, Luis A. Fernandez, Martynas Ziemelis, Juan S. Danobeitia, J. Michael Millis, Piotr Witkowski
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Selection of an optimal donor pancreas is the first key task for successful islet isolation. We conducted a retrospective multicenter study in 11 centers in North America to develop an islet donor scoring system using donor variables. The data set co
Externí odkaz:
https://doaj.org/article/9f115dc17ddc4fb39eca54c8386654f0