Zobrazeno 1 - 10
of 796
pro vyhledávání: '"MASSIMO TRUCCO"'
Autor:
Brett E. Phillips, Louise Lantier, Carl Engman, Yesica Garciafigueroa, Aatur Singhi, Massimo Trucco, Christos Mantzoros, David Wasserman, Nick Giannoukakis
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-15 (2022)
Abstract Background Liver pathology (LP) characteristic of non-alcoholic fatty acid disease (NAFLD)/non-alcoholic steatohepatitis (NASH) is a prevalent co-morbidity of type 2 diabetes (T2D). Accumulating evidence indicates that neutrophils driving in
Externí odkaz:
https://doaj.org/article/ab612ea663e24ad9bf187ea3930f8857
Autor:
Despoina Aslanoglou, Suzanne Bertera, Marta Sánchez-Soto, R. Benjamin Free, Jeongkyung Lee, Wei Zong, Xiangning Xue, Shristi Shrestha, Marcela Brissova, Ryan W. Logan, Claes B. Wollheim, Massimo Trucco, Vijay K. Yechoor, David R. Sibley, Rita Bottino, Zachary Freyberg
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central nervous system that also act in the pancreas as peripheral regulators of metabolism. Pancreatic catecholamine signaling has also been increasingly impl
Externí odkaz:
https://doaj.org/article/b9206d5d35df46e48ee2e0a5e574828b
Autor:
Suzanne Bertera, Michael F. Knoll, Carmela Knoll, Hidetaka Hara, Erin A. Kimbrel, Nickolas A. Kouris, Robert Lanza, Brett E. Philips, Yesica Garciafigueroa, Nick Giannoukakis, David K. C. Cooper, Massimo Trucco, Rita Bottino
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Islet transplantation can restore glycemic control in patients with type 1 diabetes. Using this procedure, the early stages of engraftment are often crucial to long-term islet function, and outcomes are not always successful. Numerous studies have sh
Externí odkaz:
https://doaj.org/article/c89e602512da4cb996df2f4edd9b2242
Autor:
Brett E. Phillips, Yesica Garciafigueroa, Carl Engman, Wen Liu, Yiwei Wang, Robert J. Lakomy, Wilson S. Meng, Massimo Trucco, Nick Giannoukakis
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Type 1 diabetes (T1D) is a disorder of impaired glucoregulation due to lymphocyte-driven pancreatic autoimmunity. Mobilizing dendritic cells (DC) in vivo to acquire tolerogenic activity is an attractive therapeutic approach as it results in multiple
Externí odkaz:
https://doaj.org/article/b7115775fd76459d90db58ac35351f4b
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
A growing body of evidence indicates that neutrophils are the first major leukocyte population accumulating inside the pancreas even before the onset of a lymphocytic-driven impairment of functional beta cells in type 1 diabetes mellitus (T1D). In hu
Externí odkaz:
https://doaj.org/article/1fbec8a461a243dba58e2b6e328be1a5
Autor:
Ann Zeleniak, Connor Wiegand, Wen Liu, Catherine McCormick, Ravikumar K., Amir Alavi, Haonan Guan, Suzanne Bertera, Robert Lakomy, Asako Tajima, Henry Cohen, Stephanie Wong, Lame Balikani, Benjamin Mizerak, Ziv Bar-Joseph, Massimo Trucco, Ipsita Banerjee, Yong Fan
Publikováno v:
Nature Methods. 19:1306-1319
Hematopoietic humanized (hu) mice are powerful tools for modeling the action of human immune system and are widely used for preclinical studies and drug discovery. However, generating a functional human T cell compartment in hu mice remains challengi
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Tolerogenic dendritic cells and T-regulatory cells are two immune cell populations with the potential to prevent the onset of clinical stage type 1 diabetes, and manage the beginning of underlying autoimmunity, at the time-at-onset and onwards. Initi
Externí odkaz:
https://doaj.org/article/0f25397e35ba4907a6e6a3fe471af28a
Autor:
Ann Zeleniak, Massimo Trucco
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(52)
Historically, successful allotransplantation was only achieved by utilizing powerful immunosuppressive drugs that were exposing the patient to severe opportunistic infections. The thymus of the transplant recipient renders such therapy obligatory as
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Dendritic cells (DC) are important in the onset and severity of inflammatory bowel disease (IBD). Tolerogenic DC induce T-cells to become therapeutic Foxp3+ regulatory T-cells (Tregs). We therefore asked if experimental IBD could be prevented by admi
Externí odkaz:
https://doaj.org/article/a5c7d72f11f3424e8785a5bec1250959
Autor:
Robert Simon, Breanna Perlmutter, Robert Naples, R. Matthew Walsh, John McMichael, Massimo Trucco, Rita Bottino, Julia Solomina, Toms Augustin, Jonah D. Thomas
Publikováno v:
Pancreas. 50:1000-1006
OBJECTIVES Islet cultures are routinely performed in total pancreatectomy with islet autotransplantation (TPIAT), and the need for empiric antibiotic treatment based on culture results is unknown. We evaluated the effect of postoperative antibiotic t