Zobrazeno 1 - 10
of 46
pro vyhledávání: '"MASAO, HIROTA"'
Publikováno v:
横浜市立大学論叢．社会科学系列 = The Bulletin of Yokohama City University, Social Science. 70(2):1-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::8fb26336ec8c1181f4926d9eea1825f4
http://id.nii.ac.jp/1246/00001660/
http://id.nii.ac.jp/1246/00001660/
Autor:
Ruimin Ge, Daniel Tornero, Masao Hirota, Emanuela Monni, Cecilia Laterza, Olle Lindvall, Zaal Kokaia
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-15 (2017)
Abstract Background Choroid plexus (CP) supports the entry of monocyte-derived macrophages (MDMs) to the central nervous system in animal models of traumatic brain injury, spinal cord injury, and Alzheimer’s disease. Whether the CP is involved in t
Externí odkaz:
https://doaj.org/article/1e7aac8b30324376bc069258443c6ee3
Autor:
John C. Rohloff, Tomoki Suzuki, Fowler Catherine, Matthew R Otis, Sheela Waugh, Jeffery D Carter, Wesley S. Mayfield, Steven K. Wolk, Masao Hirota, Shashi Kumar Gupta, Daniel Schneider, Yuichi Ishikawa, Daniel W. Drolet, Nebojsa Janjic
Publikováno v:
Nucleic Acid Therapeutics
The addition of novel side chains at the 5-position of uracil is an effective means to increase chemical diversity of aptamers and hence the success rate for discovery of high-affinity ligands to protein targets. Such modifications also increase nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e2da3e232b3654d056563963fb036b
https://doi.org/10.1089/nat.2017.0683
https://doi.org/10.1089/nat.2017.0683
Autor:
Masao Hirota, Hayato Kasai, Shigeru Ibaragi, Daniel J. Schneider, Shun Ichiro Sumida, Shashi Kumar Gupta, Yuichi Ishikawa, Daniel W. Drolet, Ikuo Murakami, Tomoki Suzuki, Naoto Horai, Nebojsa Janjic
Publikováno v:
Nucleic Acid Therapeutics
Interleukin-6 (IL-6) is a potent mediator of inflammatory and immune responses, and a validated target for therapeutic intervention of inflammatory diseases. Previous studies have shown that SL1026, a slow off-rate modified aptamer (SOMAmer) antagoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e490c495ea3d1777819952f80835d4a0
https://doi.org/10.1089/nat.2015.0567
https://doi.org/10.1089/nat.2015.0567
Autor:
Thale C. Jarvis, Yuichi Ishikawa, Yuichiro Nakaishi, Thomas E. Edwards, Nebojsa Janjic, Chi Zhang, John C. Rohloff, Douglas R. Davies, Jeffrey D. Carter, Shashi Kumar Gupta, Masao Hirota, Amy D. Gelinas
Publikováno v:
The Journal of Biological Chemistry
Background: Traditional aptamers favor polar interactions with protein binding partners. Results: The IL-6·SOMAmer structure reveals an interface rich in hydrophobic interactions that overlap the binding sites of IL-6 receptors. Conclusion: Hydropho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cc870b97c9cf3ca9e218cd101ea0ca
https://doi.org/10.1074/jbc.m113.532697
https://doi.org/10.1074/jbc.m113.532697
Autor:
Kazutaka Higaki, Takanori Minami, Ken Ichi Ogawara, Masateru Miyake, Hajime Toguchi, Masaaki Odomi, Toshikiro Kimura, Masao Hirota
Publikováno v:
Journal of Controlled Release. 111:27-34
In order to develop a novel oral formulation that can safely improve the intestinal absorption of poorly absorbable drugs, polyamines such as spermine (SPM) and spermidine (SPD) was examined as an absorption enhancing adjuvant in rats. The absorption
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f3763289516c86039bae5f715f0ac8
https://doi.org/10.1016/j.jconrel.2005.11.010
https://doi.org/10.1016/j.jconrel.2005.11.010
Autor:
Keisaku Fujimoto, Hitoshi Ogasawara, Yoshitaka Yamazaki, Hiroshi Yamamoto, Toshimichi Kaneki, Keishi Kubo, Masao Hirota, Tomonobu Koizumi
Publikováno v:
Japanese Journal of Pharmacology. 88:63-68
The aim of the present study is to study the pharmacokinetics in plasma, lung lymph and bronchial washing fluid after intravenous infusion of grepafloxacin (GPFX), in comparison with those of levofloxacin (LVFX). Four conscious sheep with chronically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31126d1b98c3341e64b1813881e40cb
https://doi.org/10.1254/jjp.88.63
https://doi.org/10.1254/jjp.88.63
Autor:
Kazuo Kamikawa, Masao Hirota, Shiro Kanegasaki, Koh Nakata, Tokie Totsu, Fusayo Adachi, Junichi Watanabe
Publikováno v:
Journal of Infection and Chemotherapy. 7:16-21
The bactericidal activity of two new quinolones, grepafloxacin and levofloxacin, against five strains of Mycobacterium avium was investigated in vitro. The minimum inhibitory concentrations (MICs) of these two quinolones, determined by the broth micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f016644b0a08b88d96e92d3347ce385c
https://doi.org/10.1007/s101560170029
https://doi.org/10.1007/s101560170029
Autor:
Chiyoka Shiroyama, Yoshiko Furukawa, Masao Hirota, Toshiya Yamamoto, Kyozo Hayashi, Sadakazu Miyashita
Publikováno v:
European Journal of Biochemistry. 225:1041-1046
pS2 is an estrogen-induced mRNA species that was originally identified in the breast cancer cell line MCF-7. Exposure of the cells to basic fibroblast growth factor (bFGF) at the concentration of 10-100 ng/ml for 48-72 h resulted in a marked increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0649d8b8aa5007f2c5a9002f4452e8
https://doi.org/10.1111/j.1432-1033.1994.1041b.x
https://doi.org/10.1111/j.1432-1033.1994.1041b.x
Autor:
Sumiyo Nii, Hirofumi Awatsuji, Yoshiko Furukawa, Shoei Furukawa, Yutaka Murakami, Masao Hirota, Kyozo Hayashi
Publikováno v:
Journal of Neuroscience Research. 34:539-545
To examine the regulation of nerve growth factor (NGF) gene expression with respect to neural trauma, we examined the effects of T cell-derived lymphokines on NGF synthesis/secretion in cultured mouse astrocytes. Interleukin (IL)-4 and IL-5 significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f1d1f77e0cbd57885a90ac210f3767
https://doi.org/10.1002/jnr.490340506
https://doi.org/10.1002/jnr.490340506