Zobrazeno 1 - 10
of 246
pro vyhledávání: '"MASAMI OTSUKA"'
Autor:
Mehmet Gul, Esra Ayan, Ebru Destan, J. Austin Johnson, Alaleh Shafiei, Abdullah Kepceoğlu, Merve Yilmaz, Fatma Betül Ertem, İlkin Yapici, Bilge Tosun, Nilüfer Baldir, Nurettin Tokay, Zeliş Nergiz, Gözde Karakadioğlu, Seyide Seda Paydos, Cahine Kulakman, Cengiz Kaan Ferah, Ömür Güven, Necati Atalay, Enver Kamil Akcan, Haluk Cetinok, Nazlı Eylül Arslan, Kardelen Şabanoğlu, Bengisu Aşci, Serra Tavli, Helin Gümüsboğa, Sevde Altuntaş, Masami Otsuka, Mikako Fujita, Şaban Teki̇n, Halilibrahim Çi̇ftçi̇, Serdar Durdaği, Ezgi Karaca, Burcu Kaplan Türköz, Burak Veli Kabasakal, Ahmet Kati, Hasan DeMi̇rci̇
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract High-resolution biomacromolecular structure determination is essential to better understand protein function and dynamics. Serial crystallography is an emerging structural biology technique which has fundamental limitations due to either sam
Externí odkaz:
https://doaj.org/article/f18f8cb3aa204e4c80e833bbd23b31ce
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3659 (2024)
Acquired immunodeficiency syndrome (AIDS) is an enormous global health threat stemming from human immunodeficiency virus (HIV-1) infection. Up to now, the tremendous advances in combination antiretroviral therapy (cART) have shifted HIV-1 infection f
Externí odkaz:
https://doaj.org/article/19b6ff6fb97c44a9920ada1bf445a044
Autor:
Nilüfer Bayrak, Belgin Sever, Halilibrahim Ciftci, Masami Otsuka, Mikako Fujita, Amaç Fatih TuYuN
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 50 (2023)
The development of new anticancer drugs is still ongoing as a solution to the unsatisfactory results obtained by chemotherapy patients. Our previous studies on natural product-based anticancer agents led us to synthesize a new series of Plastoquinone
Externí odkaz:
https://doaj.org/article/4577f53f83d848ab95e92f56d64b7780
Autor:
Omur Guven, Belgin Sever, Faika Başoğlu-Ünal, Abdulilah Ece, Hiroshi Tateishi, Ryoko Koga, Mohamed O. Radwan, Nefise Demir, Mustafa Can, Mutlu Dilsiz Aytemir, Jun-ichiro Inoue, Masami Otsuka, Mikako Fujita, Halilibrahim Ciftci, Hasan DeMirci
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1608 (2023)
Tumor necrosis factor receptor-associated factors (TRAFs) are a protein family with a wide variety of roles and binding partners. Among them, TRAF6, a ubiquitin ligase, possesses unique receptor binding specificity and shows diverse functions in immu
Externí odkaz:
https://doaj.org/article/1202296dce524954b7f465f6ba2024b8
Autor:
Mohamed O. Radwan, Sultan F. Kadasah, Salha M. Aljubiri, Abdulmajeed F. Alrefaei, Mahmoud H. El-Maghrabey, Mohamed A. El Hamd, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1465 (2023)
Nuclear receptors (NRs) constitute a superfamily of ligand-activated transcription factors with a paramount role in ubiquitous physiological functions such as metabolism, growth, and reproduction. Owing to their physiological role and druggability, N
Externí odkaz:
https://doaj.org/article/52955bd875054bd89301303d7d391311
Autor:
Halilibrahim Ciftci, Hiroshi Tateishi, Kotaro Koiwai, Ryoko Koga, Kensaku Anraku, Kazuaki Monde, Çağdaş Dağ, Ebru Destan, Busra Yuksel, Esra Ayan, Gunseli Yildirim, Merve Yigin, F. Betul Ertem, Alaleh Shafiei, Omur Guven, Sabri O. Besler, Raymond G. Sierra, Chun Hong Yoon, Zhen Su, Mengling Liang, Burcin Acar, Turkan Haliloglu, Masami Otsuka, Fumiaki Yumoto, Mikako Fujita, Toshiya Senda, Hasan DeMirci
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Oligomerization of Pr55Gag is a critical step of the late stage of the HIV life cycle. It has been known that the binding of IP6, an abundant endogenous cyclitol molecule at the MA domain, has been linked to the oligomerization of Pr55Gag. H
Externí odkaz:
https://doaj.org/article/77d919cd60ce407e9fad3b1b4378ff45
Autor:
Mohamed O. Radwan, Howaida I. Abd-Alla, Azhaar T. Alsaggaf, Hatem El-Mezayen, Mohammed A. S. Abourehab, Mohamed E. El-Beeh, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita
Publikováno v:
Molecules, Vol 28, Iss 15, p 5677 (2023)
In the last decade, gypsogenin has attracted widespread attention from medicinal chemists by virtue of its prominent anti-cancer potential. Despite its late identification, gypsogenin has proved itself as a new anti-proliferative player battling for
Externí odkaz:
https://doaj.org/article/e00976d304e440cfa0f3cbf7278caaeb
Autor:
Ahmed K. Hamdy, Takashi Sakamoto, Tsugumasa Toma, Masaharu Sakamoto, Mohammed A. S. Abourehab, Masami Otsuka, Mikako Fujita, Hiroshi Tateishi, Mohamed O. Radwan
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1579 (2022)
Searching for bioactive compounds within the huge chemical space is like trying to find a needle in a haystack. Isatin is a unique natural compound which is endowed with different bio-pertinent activities, especially in cancer therapy. Herein, we env
Externí odkaz:
https://doaj.org/article/32968f64fbf840838b1464f3f801751a
Autor:
Halilibrahim Ciftci, Belgin Sever, Nusret Kaya, Nilüfer Bayrak, Mahmut Yıldız, Hatice Yıldırım, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita, Amaç Fatih TuYuN
Publikováno v:
Molecules, Vol 28, Iss 1, p 77 (2022)
Colorectal cancer (CRC), breast cancer, and chronic myeloid leukemia (CML) are life-threatening malignancies worldwide. Although potent therapeutic and screening strategies have been developed so far, these cancer types are still major public health
Externí odkaz:
https://doaj.org/article/0ea0513370444aff92ed135226582c63
Autor:
Halilibrahim Ciftci, Belgin Sever, Esra Ayan, Mustafa Can, Hasan DeMirci, Masami Otsuka, Amaç Fatih TuYuN, Hiroshi Tateishi, Mikako Fujita
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1255 (2022)
The HIV-1 Gag protein binds to the host cell membrane and assembles into immature particles. Then, in the course of immature virion budding, activated protease cleaves Gag into its main components: MA, CA, NC, and p6 proteins. The highly basic residu
Externí odkaz:
https://doaj.org/article/c028dc50876040c582b307116b9e1d7c