Zobrazeno 1 - 10
of 374
pro vyhledávání: '"MASAHIRO KAWAHARA"'
Autor:
Kirato Umene, Masahiro Kawahara
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Mimicry of receptor functions by designing synthetic receptors would be one of the recently hot research trends in cell engineering. While several types of synthetic receptors have been designed to induce desired cell fates in response to ex
Externí odkaz:
https://doaj.org/article/22501eef96744147991ee6fd4311d448
Autor:
Masashi Endo, Yukiko Fukuda, Kouhei Okada, Kazunari Ogawa, Michiko Nakamura, Satoru Takahashi, Masahiro Kawahara, Keiko Akahane, Yoshiaki Nagai, Hironori Yamaguchi, Hiroshi Nishino, Harushi Mori, Katsuyuki Shirai
Publikováno v:
Case Reports in Oncology, Vol 16, Iss 1, Pp 1345-1352 (2023)
Introduction: The abscopal effect (AE) is a phenomenon, in which radiotherapy exerts an antitumour effect on distant lesions outside the primary irradiated area. Although immune checkpoint inhibitors have been widely studied for their potential to en
Externí odkaz:
https://doaj.org/article/0a061d0ecf824d3080b1c74c3a32851a
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Since cell proliferation is one of the fundamental cell fates, artificial control of cell proliferation based on a receptor-engineering approach is increasingly important in therapeutic and industrial applications. Since the signal transduct
Externí odkaz:
https://doaj.org/article/7db55c6728954b73a15fcc44d0571d98
Autor:
Ai Asai-Nishishita, Masahiro Kawahara, Goichi Tatsumi, Masaki Iwasa, Aya Fujishiro, Rie Nishimura, Hitoshi Minamiguchi, Katsuyuki Kito, Makoto Murata, Akira Andoh
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract FUS-ERG is a chimeric gene with a poor prognosis, found in myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML). It remains unclear whether DNA hypomethylating agents, including azacitidine (Aza), are effective in FUS-ERG-harbou
Externí odkaz:
https://doaj.org/article/c8ba6cb7c7764ed3b3d4020ab2466e9a
Autor:
Noriaki Yamashita, Masahiro Kawahara, Takayuki Imai, Goichi Tatsumi, Ai Asai-Nishishita, Akira Andoh
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Thiopurines, such as 6-mercaptopurine (6-MP), are widely used as cytotoxic agents and immunosuppressants for leukemia and autoimmune or inflammatory diseases. A nonsynonymous single nucleotide polymorphism (p.Arg139Cys; R139C) of the nucleos
Externí odkaz:
https://doaj.org/article/3c96629815534cc8a1d0fa30ceebdd8c
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 773 (2024)
Zinc (Zn) and copper (Cu) are essential for normal brain functions. In particular, Zn and Cu are released to synaptic clefts during neuronal excitation. Synaptic Zn and Cu regulate neuronal excitability, maintain calcium (Ca) homeostasis, and play ce
Externí odkaz:
https://doaj.org/article/1321085f2eb449ba9ebf719ca4052833
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1296 (2024)
Synaptic zinc ions (Zn2+) play an important role in the development of vascular dementia (VD) and Parkinson’s disease (PD). In this article, we reviewed the current comprehension of the Zn2+-induced neurotoxicity that leads to the pathogenesis of t
Externí odkaz:
https://doaj.org/article/d163b6d24cc540c4b22fce7a65e78ce6
Autor:
Satoru Takahashi, Masashi Endo, Takafumi Nagatomo, Ryutaro Onaga, Hironori Yamaguchi, Rie Yamamoto, Yukiko Fukuda, Kazunari Ogawa, Michiko Nakamura, Kohei Okada, Keiko Akahane, Masahiro Kawahara, Hiroshi Nishino, Takeharu Kanazawa, Harushi Mori, Katsuyuki Shirai
Publikováno v:
Case Reports in Oncology, Vol 16, Iss 1, Pp 218-226 (2023)
QUAD SHOT is an ultra-hypofractionated radiotherapy (RT) technique that prescribes 14.0–14.8 Gy over 2 days. Although this technique has already gained some status as an effective palliative treatment for inoperable head and neck cancer (HNC), its
Externí odkaz:
https://doaj.org/article/450228c2f9f9490aa42eea069604575b
Autor:
Takahiro Sogo, Shu Nakao, Tasuku Tsukamoto, Tomoe Ueyama, Yukihiro Harada, Dai Ihara, Tomoaki Ishida, Masato Nakahara, Koji Hasegawa, Yuka Akagi, Yasuyuki S. Kida, Osamu Nakagawa, Teruyuki Nagamune, Masahiro Kawahara, Teruhisa Kawamura
Publikováno v:
Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-17 (2023)
Abstract Background Canonical Wnt signaling is involved in a variety of biological processes including stem cell renewal and differentiation, embryonic development, and tissue regeneration. Previous studies reported the stage-specific roles of the Wn
Externí odkaz:
https://doaj.org/article/a50927d4e15c4b8793a2df472c93b698
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Development of a method for detecting protein–protein interactions (PPIs) in living cells is important for therapeutic drug screening against various diseases including infectious diseases. We have recently developed a method named SOS loc
Externí odkaz:
https://doaj.org/article/a6989e79de2446d69ebd3666a392c603