Zobrazeno 1 - 10
of 146
pro vyhledávání: '"MASAAKI ISHIZUKA"'
Autor:
Yoichi Iitaka, Masatomi Iijima, Shogo Kurasawa, Tomio Takeuchi, Tohru Masuda, Hikaru Nakamura, Hiroshi Naganawa, Masaaki Ishizuka, Yoshiro Okami
Publikováno v:
The Journal of Antibiotics. 71:908-909
The authors of the above article misjudged the structure determination of MCF (metacytofilin). Our recent analyses using X-ray crystallography and NMR techniques revealed the correct structure as shown in Figs. 1, 2 and 3. The structure of MCF was id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::465f514058a25a5c6f42e058837a334e
https://doi.org/10.1038/s41429-018-0045-z
https://doi.org/10.1038/s41429-018-0045-z
Autor:
Hiroyuki Kumagai, Kunio Isshiki, Masaaki Ishizuka, Kuniko Wakazono, Naoki Agata, Daishiro Ikeda
Publikováno v:
The Journal of Antibiotics. 58:202-205
The anti-diabetic effect of cytogenin was examined using streptozotocin-induced diabetes in mice. Cytogenin suppressed not only the increase of plasma glucose level but also the body weight reduction in diabetic mice. Histological examination of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789388a1eb53577db0116b0b7a1c8042
https://doi.org/10.1038/ja.2005.24
https://doi.org/10.1038/ja.2005.24
Autor:
Masaaki Ishizuka, Takashi Shinkawa, Mitsuhiro Ueno, Tohru Yamakuni, Toshiaki Isobe, Yasushi Ohizumi, Hironori Fujiwara
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 310:1288-1295
To find novel pharmacological tools useful for analyzing the molecular mechanism of apoptosis from natural resources, in the present study, we examined the activity of IC101, a cyclic depsipeptide isolated from Streptomyces sp. MJ202-72F3, to induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274b43389d845745d9108ce601dca0ca
https://doi.org/10.1124/jpet.104.065979
https://doi.org/10.1124/jpet.104.065979
Publikováno v:
Molecular and Cellular Endocrinology. 214:175-187
Androgen receptor (AR) is a ligand-activated transcription factor that requires androgen binding to initiate a series of molecular events leading to specific gene activation. AR has been suggested to form an antiparallel homodimer based on the charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9eca9ad07c04bd5660347ff18c8efd
https://doi.org/10.1016/j.mce.2003.10.060
https://doi.org/10.1016/j.mce.2003.10.060
Autor:
Kazuyuki Dobashi, Masaaki Ishizuka, Kunio Isshiki, Daishiro Ikeda, Hiroyuki Kumagai, Tetsuya Someno
Publikováno v:
The Journal of Antibiotics. 57:97-103
In the course of screening program for inhibitors of angiogenesis, novel substances designated as ICM0301A approximately H (1 approximately 8) were isolated from the culture broth of Aspergillus sp. F-1491. ICM0301s inhibited the growth of human umbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66941de34c4ca63250fbd4d4a1b7f998
https://doi.org/10.7164/antibiotics.57.97
https://doi.org/10.7164/antibiotics.57.97
Publikováno v:
Biochemical and Biophysical Research Communications. 308:866-871
Nephrotoxicity is known to be a major clinical side effect of aminoglycoside antibiotics. Aminoglycosides cause damage to proximal tubular cells in kidney, however the mechanism of toxicity is still unclear. In order to elucidate the mechanism of nep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557fe6c10610f7c1e745e1a509d3ef1f
https://doi.org/10.1016/s0006-291x(03)01502-x
https://doi.org/10.1016/s0006-291x(03)01502-x
Publikováno v:
Biochemical and Biophysical Research Communications. 306:629-636
Imbalances in the epithelial–stromal interactions are important in the pathogenesis of prostate cancer. However, we know little about androgenic regulation in the stroma of prostate cancer. We examined the cancer–stromal interaction paying attent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d3c07b5010efadfee9cfa4a16d28db
https://doi.org/10.1016/s0006-291x(03)01023-4
https://doi.org/10.1016/s0006-291x(03)01023-4
Autor:
Manabu Kawada, Shun-ichi Ohba, Tohru Masuda, Masaji Kawatsu, Masaaki Ishizuka, Masahide Amemiya, Takafumi Kohama, Tomio Takeuchi
Publikováno v:
International Immunopharmacology. 3:179-188
Selective augmentation of natural killer (NK) cells can suppress tumor metastasis, but molecular targets for NK cell activation have not been identified. We report here that cytostatin (CTS), a novel specific inhibitor of protein phosphatase (PP) 2A,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c32d3b304a6fbd95a4885750598c50b
https://doi.org/10.1016/s1567-5769(02)00231-x
https://doi.org/10.1016/s1567-5769(02)00231-x
Publikováno v:
The Journal of Antibiotics. 56:214-218
ICM0201 (1), a new inhibitor of murine osteoclastogenesis in culture was isolated from a fermentation broth of Cunninghamella sp. F-1490. The structure of ICM0201 was determined to be (3S, 10aR)-3, 4a-dihydroxy-2, 3, 4, 4a-tetrahydro-2H-pyrano[3, 2-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c959a3ef694a6e13c44cb7574e27d2
https://doi.org/10.7164/antibiotics.56.214
https://doi.org/10.7164/antibiotics.56.214