Zobrazeno 1 - 10
of 117
pro vyhledávání: '"MARTIN KREITMAN"'
Publikováno v:
eLife, Vol 10 (2021)
The immeasurable complexity at every level of biological organization creates a daunting task for understanding biological function. Here, we highlight the risks of stripping it away at the outset and discuss a possible path toward arriving at emerge
Externí odkaz:
https://doaj.org/article/2c803d46ea4f426194376ebbc2af5b4f
Publikováno v:
Genes, Vol 10, Iss 9, p 691 (2019)
Plant nucleotide-binding domain and leucine-rich repeat containing (NLR) genes provide some of the most extreme examples of polymorphism in eukaryotic genomes, rivalling even the vertebrate major histocompatibility complex. Surprisingly, this is also
Externí odkaz:
https://doaj.org/article/f43a749d883b467fbd634e52c9956afc
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 15, Iss 12, Pp 1195-1203 (2002)
We report the isolation and identification of two natural pathogens of Arabidopsis thaliana, Pseudomonas viridiflava and Pseudomonas syringae, in the midwestern United States. P. viridiflava was found in six of seven surveyed Arabidopsis thaliana pop
Externí odkaz:
https://doaj.org/article/c56ecc06e0ec4567a66ee4a494f87ab0
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e91924 (2014)
Changes in regulatory DNA contribute to phenotypic differences within and between taxa. Comparative studies show that many transcription factor binding sites (TFBS) are conserved between species whereas functional studies reveal that some mutations s
Externí odkaz:
https://doaj.org/article/51a075493ae9411b80b62b5180ab2461
Autor:
Ling-Wen Zeng, Martin Kreitman
Publikováno v:
BioTechniques, Vol 21, Iss 3, Pp 446-452 (1996)
We describe a simple method for constructing subclones containing overlapping nested deletions from cDNA clones (both λ phage clones and plasmid clones). A PCRamplified insert is partially digested with 4-cutter restriction enzyme(s). Complete diges
Externí odkaz:
https://doaj.org/article/4c7e799e075941a5a92f7a91e442a15b
Publikováno v:
PLoS Genetics, Vol 7, Iss 11, p e1002364 (2011)
The regulatory logic of time- and tissue-specific gene expression has mostly been dissected in the context of the smallest DNA fragments that, when isolated, recapitulate native expression in reporter assays. It is not known if the genomic sequences
Externí odkaz:
https://doaj.org/article/a65d01fba5cf4aa6b26a914aa801676b
Publikováno v:
PLoS Genetics, Vol 7, Iss 4, p e1002053 (2011)
Transcription factor binding site(s) (TFBS) gain and loss (i.e., turnover) is a well-documented feature of cis-regulatory module (CRM) evolution, yet little attention has been paid to the evolutionary force(s) driving this turnover process. The predo
Externí odkaz:
https://doaj.org/article/4022592c8fb54f9684852fea022fee9f
Autor:
Magnus Nordborg, Tina T Hu, Yoko Ishino, Jinal Jhaveri, Christopher Toomajian, Honggang Zheng, Erica Bakker, Peter Calabrese, Jean Gladstone, Rana Goyal, Mattias Jakobsson, Sung Kim, Yuri Morozov, Badri Padhukasahasram, Vincent Plagnol, Noah A Rosenberg, Chitiksha Shah, Jeffrey D Wall, Jue Wang, Keyan Zhao, Theodore Kalbfleisch, Vincent Schulz, Martin Kreitman, Joy Bergelson
Publikováno v:
PLoS Biology, Vol 3, Iss 7, p e196 (2005)
We resequenced 876 short fragments in a sample of 96 individuals of Arabidopsis thaliana that included stock center accessions as well as a hierarchical sample from natural populations. Although A. thaliana is a selfing weed, the pattern of polymorph
Externí odkaz:
https://doaj.org/article/9b9ec1d616304098ac3ae9ff919c988b
Autor:
Michael Z Ludwig, Arnar Palsson, Elena Alekseeva, Casey M Bergman, Janaki Nathan, Martin Kreitman
Publikováno v:
PLoS Biology, Vol 3, Iss 4, p e93 (2005)
Lack of knowledge about how regulatory regions evolve in relation to their structure-function may limit the utility of comparative sequence analysis in deciphering cis-regulatory sequences. To address this we applied reverse genetics to carry out a f
Externí odkaz:
https://doaj.org/article/ffb9c480d2514707a39ae49b348e934c
Publikováno v:
Journal of Evolutionary Biology.