Zobrazeno 1 - 10
of 85
pro vyhledávání: '"MARK E. HURTT"'
Autor:
Mark E. Hurtt, Geertje Lewin
Publikováno v:
Birth Defects Research. 109:1519-1539
The purpose of this review is to give an outline of respiratory tract morphological and functional development with an emphasis on perinatal and postnatal maturational processes. In view of the rising need for qualitative and quantitative data for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfaeb53a93007c89674d3f0e51471648
https://doi.org/10.1002/bdr2.1089
https://doi.org/10.1002/bdr2.1089
Autor:
Mark E. Hurtt, Scott Engel
Publikováno v:
Reproductive Toxicology. 56:105-108
Concern has been raised about the number of juvenile animal studies (JAS) being conducted in the European Union (EU) and the number of species required. The question of whether there has been an increase in the number of JAS requested by European Med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30134b1cc938d699660bb93758a9c06c
https://doi.org/10.1016/j.reprotox.2015.04.011
https://doi.org/10.1016/j.reprotox.2015.04.011
Autor:
Geertje, Lewin, Mark E, Hurtt
Publikováno v:
Birth defects research. 109(19)
The purpose of this review is to give an outline of respiratory tract morphological and functional development with an emphasis on perinatal and postnatal maturational processes. In view of the rising need for qualitative and quantitative data for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa99259e66e366f078b306d58a2402d4
https://pubmed.ncbi.nlm.nih.gov/28876535
https://pubmed.ncbi.nlm.nih.gov/28876535
Autor:
Gregg D. Cappon, Mark E. Hurtt, David M. Potter, C.M. Luetjens, Christopher J. Bowman, Gerhard F. Weinbauer
Publikováno v:
Reproductive Toxicology. 41:67-72
To determine the sensitivity of male reproductive toxicity endpoints in NHPs we performed a power analysis of routine and triggered endpoints using control data from sexually mature Asian and Mauritian NHPs. The power to detect a 50% change from cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d514033ea0d3039f091ed57865bf802
https://doi.org/10.1016/j.reprotox.2013.06.061
https://doi.org/10.1016/j.reprotox.2013.06.061
Comparative assessment of the timing of sexual maturation in male Wistar Han and Sprague-Dawley rats
Autor:
Sarah N. Campion, William S. Nowland, Timothy R. Winton, Gregg D. Cappon, Rebecca Koitz, Mark E. Hurtt, Francisco R. Carvallo, Raul T Jamon, David Beauchamp, Robert E. Chapin
Publikováno v:
Reproductive Toxicology. 38:16-24
Given the increasing use of Wistar Han (WH) rats in regulatory toxicology studies, these studies were performed to characterize the onset of sexual maturation in maturing WH rats as compared to Sprague-Dawley (SD) rats. Beginning on postnatal day (PN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d33db1502377b6b153efbb7b70ded12
https://doi.org/10.1016/j.reprotox.2013.02.003
https://doi.org/10.1016/j.reprotox.2013.02.003
Autor:
Gregg D. Cappon, Mark E. Hurtt
Publikováno v:
Reproductive Toxicology ISBN: 9780429146763
INTRODUCTION Human renal development involves two basic processes, the morphological development of kidney cells and structure followed by the acquisition of function. The anatomic formation of the human kidney occurs exclusively in utero. However, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::000be31097d75c81e4a21f597bf62bbf
https://doi.org/10.3109/9781420073447-14
https://doi.org/10.3109/9781420073447-14
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 95:354-362
An important aspect of the enhanced pre- and postnatal developmental (ePPND) toxicity study in nonhuman primates (NHP) is that it combines in utero and postnatal assessments in a single study. However, it is unclear if NHP ePPND studies are suitable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::594653e94cd4ddb0275bb1acce17b54b
https://doi.org/10.1002/bdrb.21025
https://doi.org/10.1002/bdrb.21025
Autor:
Sarah N. Campion, Mark E. Hurtt, Gregg D. Cappon, William S. Nowland, Christopher J. Bowman, Scott J. Davenport
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 95:238-249
The critical periods of axial skeletal development in rats and mice have been well characterized, however the timing of skeletal development in rabbits is not as well known. It is important to have a more precise understanding of this timing of axial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40194df0727c16b7099c6a7a9a39b5b2
https://doi.org/10.1002/bdrb.21013
https://doi.org/10.1002/bdrb.21013
Autor:
Gregg D. Cappon, Mark E. Hurtt, Sarah N. Campion, Anthony Harrison, Gregory L. Finch, Christopher J. Bowman
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 95:250-261
Background: Lersivirine is a second-generation nonnucleoside reverse transcriptase inhibitor undergoing clinical development for the treatment of human immunodeficiency virus-1. An embryo-fetal development study was performed to evaluate the potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17719827c23445751dd8d2dfae2c81f6
https://doi.org/10.1002/bdrb.21014
https://doi.org/10.1002/bdrb.21014
Autor:
Gregg D. Cappon, Christopher J. Bowman, Sarah N. Campion, Elise M. Lewis, Gregory L. Finch, Mark E. Hurtt, Gary W. Chmielewski
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 95:225-230
Lersivirine is a second-generation nonnucleoside reverse transcriptase inhibitor undergoing clinical development for the treatment of HIV-1. An embryo-fetal developmental toxicity study was performed to evaluate the maternal and developmental toxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14dbd8771e834c3d8eee073d3bb1ad66
https://doi.org/10.1002/bdrb.21008
https://doi.org/10.1002/bdrb.21008