Zobrazeno 1 - 10
of 70
pro vyhledávání: '"MARK E. GOLDMAN"'
Autor:
Daniel Grant, Peter Teriete, John C. Reed, Pooi-San Lee, Anna Dembo, Douglas J. Sheffler, Nicholas D. P. Cosford, Haixia Zou, Gavin Magnuson, Allison S. Limpert, Jiwen Zou, Anthony B. Pinkerton, Mark E. Goldman, Robert Ardecky, Juan Rong
Publikováno v:
ACS Chemical Neuroscience
Endoplasmic reticulum (ER) stress causes neuronal dysfunction followed by cell death and is recognized as a feature of many neurodegenerative diseases. Using a phenotypic screen, we recently identified benzodiazepinone derivatives that reduce ER stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3765e5e274ee9a6fd3a4d5f98c7f45db
https://doi.org/10.1021/cn500297v
https://doi.org/10.1021/cn500297v
Publikováno v:
FEBS Journal. 273:3054-3062
We report a detailed kinetic investigation of the aminoglycosides neomycin B and neamine as inhibitors of the lethal factor protease from Bacillus anthracis. Both inhibitors display a mixed-type, noncompetitive kinetic pattern, which suggests the exi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239ac1229701ffdf2a354a7ab291d1f1
https://doi.org/10.1111/j.1742-4658.2006.05316.x
https://doi.org/10.1111/j.1742-4658.2006.05316.x
Autor:
James P. Edwards, Todd K. Jones, Keith B. Marschke, Ming-Wei Wang, Pooley Charlotte L F, Mark E. Goldman, Diane L. Crombie
Publikováno v:
Journal of Medicinal Chemistry. 41:3461-3466
A series of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines was synthesized and tested for functional activity on the human progesterone receptor isoform B (hPR-B) in mammalian (CV-1) cells. The lead compound LG001447 (1,2-dihydro-2,2, 4-trimethyl-6-phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72afa835b33262a3b787dfc56b7c1d35
https://doi.org/10.1021/jm9801915
https://doi.org/10.1021/jm9801915
Publikováno v:
SLAS Discovery. 2:213-223
Activated transcription factor AP-1 is composed of c-Jun homodimers or c-Jun/c-Fos heterodimers and mediates expression of several gene products that have been implicated in disease pathogenesis. Activation of AP-1 is dependent on phosphorylation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::559fa3d7ae3afd700e14c18da25a9105
https://doi.org/10.1177/108705719700200406
https://doi.org/10.1177/108705719700200406
Autor:
Todd K. Jones, Robert B. Stein, Teodoro Ianiro, Luc J. Farmer, Mark E. Goldman, Michael G. Johnson, Dale E. Mais, Charles Pathirana, Bender Steven Lee, Lawrence G. Hamann
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 56:61-66
Utilizing the co-transfection assay as a guide to determining structure activity relationships, we have been pursuing the discovery of non-steroidal hPR modulators. Small molecule, non-steroidal lead structures have been identified. Optimization of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71acb76bc64801e1b9a8d078d0f1a9af
https://doi.org/10.1016/0960-0760(95)00224-3
https://doi.org/10.1016/0960-0760(95)00224-3
Autor:
Michael G. Johnson, Mark E. Goldman, Diane Crombie, Bender Steven Lee, Dale E. Mais, Luc J. Farmer, Ming-Wei Wang, Todd K. Jones, Lawrence G. Hamann
Publikováno v:
Journal of Medicinal Chemistry. 39:1778-1789
A novel class of nonsteroidal progesterone receptor antagonists has been synthesized and was shown to exhibit moderate binding affinity for hPR-A, the ability to inhibit the transcriptional activity of human progesterone receptor (hPR) in cell-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c76e1baf572250414a8e8069fbe3a33
https://doi.org/10.1021/jm950747d
https://doi.org/10.1021/jm950747d
Autor:
Richard G. Ball, William C. Lumma, S. F. Britcher, Catherine M. Wiscount, Steven D. Young, William M. Sanders, Mark E. Goldman, Terry A. Lyle, Thomas J. Tucker, Julie A. O'Brien
Publikováno v:
Journal of Medicinal Chemistry. 37:2437-2444
As part of an ongoing effort to prepare novel non-nucleoside inhibitors of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT), a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin -2(1H)-ones 4aa-l has been pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab311bbc3181e7107970feb1db80c6a7
https://doi.org/10.1021/jm00041a023
https://doi.org/10.1021/jm00041a023
Autor:
Mark E. Goldman, Donald P. McDonnell
Publikováno v:
Journal of Biological Chemistry. 269:11945-11949
The human progesterone receptor (hPR) exists in two distinct forms in most cells, hPR-A and hPR-B. Both receptor isoforms exhibit distinct biological functions and demonstrate a cell- and promoter-specific ability to regulate gene transcription. Inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9641a6ef2a3acacd640dc48391ff958e
https://doi.org/10.1016/s0021-9258(17)32664-9
https://doi.org/10.1016/s0021-9258(17)32664-9
Autor:
David J. Mangelsdorf, Richard A. Heyman, Marcus F. Boehm, Michael R. McClurg, Jonathan J. Hebert, Charles Pathirana, Steven K. White, David T. Winn, Mark E. Goldman
Publikováno v:
Journal of Medicinal Chemistry. 37:408-414
all-trans-Retinoic acid is known to bind to the retinoic acid receptors (RARs) resulting in an increase in their transcriptional activity. In contrast, recently identified 9-cis-retinoic acid (9-cis-RA), which is an additional endogenous RA isomer, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f579e9f25e45205dd4d52e778b95d3a0
https://doi.org/10.1021/jm00029a013
https://doi.org/10.1021/jm00029a013
Autor:
Donald P. McDonnell, Manouchehr M. Shahbaz, Mark E. Goldman, Elisabetta Vegeto, D. X. Wen, Bert W. O'Malley
Publikováno v:
Molecular Endocrinology. 7:1244-1255
Two distinct isoforms of the human progesterone receptor (hPR-A and hPR-B) have been identified previously. They differ only in that hPR-B contains an additional 164 amino acids at the amino terminus. Among various species these two forms arise as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1112fc383b004159059ae716425633cc
https://doi.org/10.1210/mend.7.10.8264658
https://doi.org/10.1210/mend.7.10.8264658