Zobrazeno 1 - 10
of 117
pro vyhledávání: '"MARK DILWORTH"'
Autor:
Edward D. Johnstone, Melissa Westwood, Mark Dilworth, Jonathan R. Wray, Alexandra C. Kendall, Anna Nicolaou, Jenny E. Myers
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 1, Pp 100312- (2023)
Sphingolipids like sphingosine-1-phosphate (S1P) have been implicated in the pathophysiology of pre-eclampsia. We hypothesized that plasma S1P would be increased in women at high risk of developing pre-eclampsia who subsequently develop the disease.
Externí odkaz:
https://doaj.org/article/6c879149de484f87af6c97aaf31f9ca7
Autor:
Joanne D. Stockton, Louise Tee, Celina Whalley, Jonathan James, Mark Dilworth, Rachel Wheat, Thomas Nieto, S-CORT Consortium, Ian Geh, João D. Barros-Silva, Andrew D. Beggs
Publikováno v:
Radiation Oncology, Vol 16, Iss 1, Pp 1-12 (2021)
Abstract Background Pathological complete response (pathCR) in rectal cancer is beneficial, as up to 75% of patients do not experience regrowth of the primary tumour, but it is poorly understood. We hypothesised that the changes seen in the pre-treat
Externí odkaz:
https://doaj.org/article/e778f28ee9ec4faebfafc381306dd3be
Autor:
Ashish Awasthi, Jamie Barbour, Andrew Beggs, Pradeep Bhandari, Daniel Blakeway, Matthew Brookes, James Brown, Matthew Brown, Germaine Caldwell, Samuel Clokie, Ben Colleypriest, Abby Conlin, Shanika de Silva, John de Caestecker, Jonathan Deeks, Anjan Dhar, Mark Dilworth, Edward Fogden, Stephen Foley, Deb Ghosh, Leonie Grellier, Ailsa Hart, Syed Samiul Hoque, Marietta Iacucci, Tariq Iqbal, Jonathan James, Mark Jarvis, Anthoor Jayaprakash, Satish Keshav, Laura Magill, Glenn Matthews, Joel Mawdsley, Simon McLaughlin, Samir Mehta, Kevin Monahan, Dion Morton, Senthil Murugesan, Miles Parkes, Valerie Pestinger, Chris Probert, Arvind Ramadas, Alessandro Rettino, Shaji Sebastian, Naveen Sharma, Michael Griffiths, Joanne Stockton, Venkat Subramanian, Nigel Suggett, Philippe Taniere, Julian Teare, Ajay M Verma, Yvonne Wallis
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 8, Iss 1 (2021)
Background: Chronic ulcerative colitis is a large bowel inflammatory condition associated with increased colorectal cancer risk over time, resulting in 1000 colectomies per year in the UK. Despite intensive colonoscopic surveillance, 50% of cases pro
Externí odkaz:
https://doaj.org/article/0dc01abacbe24fca9990d9312a441d4a
Autor:
Nigel J Hall, David Williams, Vivek Gupta, Anna-may Long, Nuha Yassin, Alan Askari, David Colvin, Stewart Cleeve, Arun Kelay, Chris Driver, Clare Rees, Eleri Cusick, Hetal Patel, Ingo Jester, Khalid Elmalik, Sean Marven, Tim Bradnock, Oliver Brown, Andrew Jackson, Richard Egan, Laura Phillips, Marianne Hollyman, Bankole Oyewole, Fenella Welsh, Dale Vimalachandran, Melissa Gabriel, Kate Cross, Iain Yardley, Mark Peter, Andrew Beamish, Sophie Lewis, Milan Gopal, Joshua McIntyre, Merrill McHoney, Ionica Stoica, Hany Gabra, Tristan Boam, Angeliki Kosti, Katie cross, Andrew Mitchell, Michael Terry, George S Bethell, Clare M Rees, Jonathan R Sutcliffe, Florin Djendov, Victor Emordi, Sarah Staight, Christina Major, Oscar Croysdale, Mike Nelson, Hannah Rhodes, Juliette King, Gillian Winter, Selena Curkovic, Raef Jackson, Bhushanrao Jadhav, Thomas Raymond, Vijay Gangalam, Deepak Selvakumar, Reda Habak, Muslim Abdullah, Mohamed Ahmed Osama, Khlud Asanai, Noman Zafar, Sophia Lewis, Florence Kashora, Dixa Thakrar, Dean Rex, Annita Budzanowski, Jennifer Binnington, Simon Timbrell, Megan Ridgeway, Shirley Chan, Amani Asour, Adetayo Aderombi, Donald Menzies, Ali Murtada, Corina Dragu, Vincent Quan, Krashna Patel, Sesi Hotonu, Ashley Meikle, Ajay Belgaumkar, Prabhat Narayan, Thomas Badenoch, Frances Goulder, Katie Siggens, Kizzie Peters, Fiona Kirkham, Paul Froggatt, Karen Lai, Cristina Navarro, Dorinda Chandrabose, Simon Toh, Elizabeth Gemmill, Keira Lily, Mark Dilworth, Dimitrios Stamatiou, Alasdair Macmillan, Danielle Clyde, Majid Rashid, Gandrapu Srinivas, Katherine Buckley, Darren Smith, Henry Dowson, Gautam Singh, Seshu Kumar Bylapudi, Louise Phillips, Kimberley Hallam, Marisa Clemente, Karol Pal, George Ninkovic-Hall, Emila Paul, Theo Pelly, Joe Vance-Daniel, Venkatesh Kanakala, Edward J Nevins, James Dixon, Michael John, Jude Prince, Georgios Karagiannidis, Suzette Samlalsingh, Chrsitine Ozone, Amina Bouhelal, Siddhartha Handa, Sathasivam Rajeev, Ellen Ross, Ali Wadah, John Hallett, Shirish Tewari, Vinay Shah, Nick Reay-Jones, Salman Bodla, Harriet Corbett, Sumita Chhabra, Athanasios Tyraskis, Benjamin Allin, Angus Fitchie, Michael Stanton, Mark Vipond, Harry Dean, Matthew Boal, Jonathan Goring, Mahmoud Marei, Christian Verhoef, Jonathan Ducey, Chipo Mushonga, Dan Frith, Ashok Ram, Ferzine Mohamed, Rick MacMahon, Mohammed Fakhrul-Aldeen, Iain Bain, Graham Branagan, Rachel Carten, Chee Wan Lai, Anindya Niyogi, Claudia Koh, Christian Fox, Stavros Loukogeorgakis, Joe Curry, Jayaram Sivaraj, Milda Jancauskaite, Helen Please, Wayne Fradley, Maki Jitsumara, Sinead Hassett, Ancuta Muntean, Sarah Yassin, Suzanne Lawther, Ciaran Durand, Mohamed Eltom, Kirsty Brennan, Clara Chong, Hasan Mukhtar, Hany Khalil, Stephanie Clark, Ashish Desai, Amulya Saxena, Joshua Cave, Alistair Sharples, Lukas O’Brien, George Kerans, Ashwini Ghorpade, Felicity Arthur, Muhammad Tobbal, Rachael Robertson, Ben Martin, Ben Woodward, Kieran McGovern, Duncan Rutherford
Publikováno v:
BMJ Paediatrics Open, Vol 4, Iss 1 (2020)
Objectives Acute appendicitis is the most common surgical condition in children. In the UK, appendicectomy is the most common treatment with non-operative management unusual. Due to concerns about the risk of SARS-CoV-2 transmission during surgical p
Externí odkaz:
https://doaj.org/article/1249b4946c344dadb8a9298b82bf5d73
Autor:
Haitham H, Khalil, David, McArthur, Sherif, Youssif, Kareem, Alsharkawy, Charles, Hendrickse, Mark, Dilworth, Sharad, Karandikar
Publikováno v:
Annals of Plastic Surgery. 89:306-311
Modern interdisciplinary concepts with involvement of various surgical specialties can considerably reduce perioperative morbidity after sacroperineal resection of locally advanced primary or recurrent anorectal malignancies. Resultant defects can re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24f1ae3cb018506161705bd56507b9a
https://doi.org/10.1097/sap.0000000000003258
https://doi.org/10.1097/sap.0000000000003258
Autor:
Susan L. Greenwood, Kirsty M.M. Vincent, Colin P. Sibley, Michelle Desforges, Christina Hayward, Kirsty McIntyre, Xiaojia Li, Mark Dilworth
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Mcintyre, K, Vincent, K, Hayward, C, Li, X, Sibley, C, Desforges, M, Greenwood, S & Dilworth, M 2020, ' Human placental uptake of glutamine and glutamate is reduced in fetal growth restriction ', Scientific Reports, vol. 10, no. 1, 16197 . https://doi.org/10.1038/s41598-020-72930-7
Mcintyre, K, Vincent, K, Hayward, C, Li, X, Sibley, C, Desforges, M, Greenwood, S & Dilworth, M 2020, ' Human placental uptake of glutamine and glutamate is reduced in fetal growth restriction ', Scientific Reports, vol. 10, no. 1, 16197 . https://doi.org/10.1038/s41598-020-72930-7
Fetal growth restriction (FGR) is a significant risk factor for stillbirth, neonatal complications and adulthood morbidity. Compared with those of appropriate weight for gestational age (AGA), FGR babies have smaller placentas with reduced activity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd054bf78226a9d7bea4caf28de9810a
http://link.springer.com/article/10.1038/s41598-020-72930-7
http://link.springer.com/article/10.1038/s41598-020-72930-7
Autor:
Eric B. Thorstensen, Philip N. Baker, Susan L. Greenwood, Colin P. Sibley, Mark Wareing, Lewis Renshall, Elizabeth Cottrell, Mark Dilworth, Elizabeth Cowley
Publikováno v:
Renshall, L, Cottrell, E, Cowley, E, Sibley, C, Baker, P N, Thortensen, E B, Greenwood, S, Wareing, M & Dilworth, M 2020, ' Antenatal sildenafil citrate treatment increases offspring blood pressure in the placental-specific Igf2 knockout mouse model of FGR ', American Journal of Physiology: Heart and Circulatory Physiology, vol. 318, no. 2, pp. H252-H263 . https://doi.org/10.1152/ajpheart.00568.2019
Fetal growth restriction (FGR), where a fetus fails to reach its genetic growth potential, affects up to 8% of pregnancies and is a major risk factor for stillbirth and adulthood morbidity. There are currently no treatments for FGR, but candidate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012d3d895eaa544bcec6f8dc419e5bf4
https://doi.org/10.1152/ajpheart.00568.2019
https://doi.org/10.1152/ajpheart.00568.2019
Publikováno v:
British Journal of Surgery. 108
Aim Good practice set out by the GMC and DoH is to acquire written informed consent for surgery, despite it not being a legal requirement. Baseline data of 50 consecutive surgical cases, undertaken in the UK’s largest trust, found that only 12% of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51504138472318730afafaa5286ee3ff
https://doi.org/10.1093/bjs/znab362.075
https://doi.org/10.1093/bjs/znab362.075
Publikováno v:
Mcintyre, K R, Hayward, C E, Sibley, C P, Greenwood, S L & Dilworth, M R 2019, ' Evidence of adaptation of maternofetal transport of glutamine relative to placental size in normal mice, and in those with fetal growth restriction ', The Journal of physiology . https://doi.org/10.1113/JP278226, https://doi.org/10.1113/JP278226
The Journal of Physiology
The Journal of Physiology
Key points Fetal growth restriction (FGR) is a major risk factor for stillbirth and has significant impact upon lifelong health.A small, poorly functioning placenta, as evidenced by reduced transport of nutrients to the baby, underpins FGR. It remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5498dff0164c362b2335bc994f6d5efa
https://doi.org/10.1113/jp278226
https://doi.org/10.1113/jp278226
Publikováno v:
Placenta. 112:e88-e89
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5876600e016fd61b09dcd4ae4714f6ad
https://doi.org/10.1016/j.placenta.2021.07.284
https://doi.org/10.1016/j.placenta.2021.07.284