Zobrazeno 1 - 10
of 92
pro vyhledávání: '"MARK A. HERMAN"'
Autor:
Liora S. Katz, Gabriel Brill, Pili Zhang, Anil Kumar, Sharon Baumel-Alterzon, Lee B. Honig, Nicolás Gómez-Banoy, Esra Karakose, Marius Tanase, Ludivine Doridot, Alexandra Alvarsson, Bennett Davenport, Peng Wang, Luca Lambertini, Sarah A. Stanley, Dirk Homann, Andrew F. Stewart, James C. Lo, Mark A. Herman, Adolfo Garcia-Ocaña, Donald K. Scott
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
ChREBP is a glucose-responsive transcription factor, which regulates glucose-mediated proliferation and cell death in pancreatic β-cells. Here the authors show that the acute feed forward induction of ChREBPβ is required for adaptive β-cell expans
Externí odkaz:
https://doaj.org/article/f2c908c5343543e98a1a127b3ec55963
Autor:
Ashot Sargsyan, Ludivine Doridot, Sarah A. Hannou, Wenxin Tong, Harini Srinivasan, Rachael Ivison, Ruby Monn, Henry H. Kou, Jonathan M. Haldeman, Michelle Arlotto, Phillip J. White, Paul A. Grimsrud, Inna Astapova, Linus T. Tsai, Mark A. Herman
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
Carbohydrate response element–binding protein (ChREBP) is a carbohydrate-sensing transcription factor that regulates both adaptive and maladaptive genomic responses in coordination of systemic fuel homeostasis. Genetic variants in the ChREBP locus
Externí odkaz:
https://doaj.org/article/ade443ac94814a119908baff8633073d
Autor:
Ghideon Ezaz, Hirsh D. Trivedi, Margery A. Connelly, Claudia Filozof, Kellie Howard, Mark L.Parrish, Misung Kim, Mark A. Herman, Imad Nasser, Nezam H. Afdhal, Z. Gordon Jiang, Michelle Lai
Publikováno v:
Hepatology Communications, Vol 4, Iss 5, Pp 670-680 (2020)
Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous disease driven by genetic and environmental factors. MicroRNAs (miRNAs) serve as pleiotropic post‐transcriptional regulators of cellular pathways. Although several miRNAs have been associa
Externí odkaz:
https://doaj.org/article/3e31e44a9bf34567b3f367787a2d4008
Autor:
Phillip J. White, Robert W. McGarrah, Mark A. Herman, James R. Bain, Svati H. Shah, Christopher B. Newgard
Publikováno v:
Molecular Metabolism, Vol 52, Iss , Pp 101261- (2021)
Background: A strong association of obesity and insulin resistance with increased circulating levels of branched-chain and aromatic amino acids and decreased glycine levels has been recognized in human subjects for decades. Scope of review: More rece
Externí odkaz:
https://doaj.org/article/9395a62ec95e46e7ace7ae86a43ec215
Autor:
Liora S. Katz, Gabriel Brill, Pili Zhang, Anil Kumar, Sharon Baumel-Alterzon, Lee B. Honig, Nicolás Gómez-Banoy, Esra Karakose, Marius Tanase, Ludivine Doridot, Alexandra Alvarsson, Bennett Davenport, Peng Wang, Luca Lambertini, Sarah A. Stanley, Dirk Homann, Andrew F. Stewart, James C. Lo, Mark A. Herman, Adolfo Garcia-Ocaña, Donald K. Scott
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/de30955e01f54ed4b9fb1d77ba69bc7b
Autor:
Bynvant Sandhu, Maria C. Perez Matos, Stephanie Tran, Alexander Zhong, Eva Csizmadia, Misung Kim, Mark A. Herman, Imad Nasser, Michelle Lai, Z. Gordon Jiang
Publikováno v:
JHEP Reports, Vol 1, Iss 3, Pp 199-202 (2019)
Background & Aims: The I148M variant (rs738409) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) is by far the most important genetic determinant of non-alcoholic fatty liver disease (NAFLD). However, in the context of NAFLD, the tr
Externí odkaz:
https://doaj.org/article/d104e3d15577434a888733c1c309463a
Autor:
Christopher J. Danford, Margery A. Connelly, Irina Shalaurova, Misung Kim, Mark A. Herman, Imad Nasser, James D. Otvos, Nezam H. Afdhal, Z. Gordon Jiang, Michelle Lai
Publikováno v:
Hepatology Communications, Vol 2, Iss 12, Pp 1467-1478 (2018)
Nonalcoholic fatty liver disease (NAFLD) is a complex disease dictated by both genetic and environmental factors. While insulin resistance (IR) is a key pathogenic driver, two common genetic variants in patatin‐like phospholipase domain containing
Externí odkaz:
https://doaj.org/article/67bd652349954a62aa0fb703e5769fbd
Autor:
Danielle E. Haslam, Gina M. Peloso, Mark A. Herman, Josée Dupuis, Alice H. Lichtenstein, Caren E. Smith, Nicola M. McKeown
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 5 (2020)
Background Limited data are available on the prospective relationship between beverage consumption and plasma lipid and lipoprotein concentrations. Two major sources of sugar in the US diet are sugar‐sweetened beverages (SSBs) and 100% fruit juices
Externí odkaz:
https://doaj.org/article/dbe61080f0824ace98f6ffa867849c3f
Autor:
Kasper W. ter Horst, Pim W. Gilijamse, Ahmet Demirkiran, Bart A. van Wagensveld, Mariette T. Ackermans, Joanne Verheij, Johannes A. Romijn, Max Nieuwdorp, Eleftheria Maratos-Flier, Mark A. Herman, Mireille J. Serlie
Publikováno v:
Molecular Metabolism, Vol 6, Iss 11, Pp 1493-1502 (2017)
Objective: Fructose consumption has been implicated in the development of obesity and insulin resistance. Emerging evidence shows that fibroblast growth factor 21 (FGF21) has beneficial effects on glucose, lipid, and energy metabolism and may also me
Externí odkaz:
https://doaj.org/article/45fb8f00eaf645dcbdade66a9f0d30fd
Autor:
ffolliott M. Fisher, MiSung Kim, Ludivine Doridot, Jeremy C. Cunniff, Thomas S. Parker, Daniel M. Levine, Marc K. Hellerstein, Lisa C. Hudgins, Eleftheria Maratos-Flier, Mark A. Herman
Publikováno v:
Molecular Metabolism, Vol 6, Iss 1, Pp 14-21 (2017)
Objective: Increased fructose consumption is a contributor to the burgeoning epidemic of non-alcoholic fatty liver disease (NAFLD). Recent evidence indicates that the metabolic hormone FGF21 is regulated by fructose consumption in humans and rodents
Externí odkaz:
https://doaj.org/article/be0b2ef84c694af884a7e7f9d6087584