Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole

Autor: Jair Téllez, Ibeth Romero, Alvaro José Romanha, Mario Steindel

Publikováno v: Parasites & Vectors, Vol 12, Iss 1, Pp 1-9 (2019)

Abstract Background Chagas disease is a potentially life-threatening disease caused by the protozoan parasite Trypanosoma cruzi. Current therapeutic management is limited to treatment with nitroheterocyclic drugs, such as nifurtimox (NFX) and benznid

Externí odkaz: https://doaj.org/article/63f274991f7c410da0cddfd7ea3f7fc0

Transsulfuration is an active pathway for cysteine biosynthesis in Trypanosoma rangeli

Autor: Ibeth Romero, Jair Téllez, Lais Eiko Yamanaka, Mario Steindel, Alvaro José Romanha, Edmundo Carlos Grisard

Publikováno v: Parasites & Vectors, Vol 7, Iss 1, Pp 1-11 (2014)

Abstract Background Cysteine, a sulfur-containing amino acid, plays an important role in a variety of cellular functions such as protein biosynthesis, methylation, and polyamine and glutathione syntheses. In trypanosomatids, glutathione is conjugated

Externí odkaz: https://doaj.org/article/5d1a4d8a356d47af81114a66ff44b6b8

Biological, biochemical and molecular features of Trypanosoma cruzi strains isolated from patients infected through oral transmission during a 2005 outbreak in the state of Santa Catarina, Brazil: its correspondence with the new T. cruzi Taxonomy Consensus (2009)

Autor: Sonia Gumes Andrade, Rozália Figueira Campos, Mario Steindel, Marcos Lázaro Guerreiro, Juracy Barbosa Magalhães, Marcio Cerqueira de Almeida, Joice Neves Reis, Viviane Corrêa Santos, Helder Magno Silva Valadares, Mitermayer Galvão dos Reis, Andréa Mara Macedo

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 106, Iss 8, Pp 948-956 (2011)

We examined strains of Trypanosoma cruzi isolated from patients with acute Chagas disease that had been acquired by oral transmission in the state of Santa Catarina, Brazil (2005) and two isolates that had been obtained from a marsupial (Didelphis au

Externí odkaz: https://doaj.org/article/7a48975e4e21457788e5cebef77ea914

Multilocus sequence analysis for Leishmania braziliensis outbreak investigation.

Autor: Mariel A Marlow, Mariana C Boité, Gabriel Eduardo M Ferreira, Mario Steindel, Elisa Cupolillo

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 2, p e2695 (2014)

With the emergence of leishmaniasis in new regions around the world, molecular epidemiological methods with adequate discriminatory power, reproducibility, high throughput and inter-laboratory comparability are needed for outbreak investigation of th

Externí odkaz: https://doaj.org/article/1c3854d4dd64420386eff28adb83e393

Genome of Herbaspirillum seropedicae strain SmR1, a specialized diazotrophic endophyte of tropical grasses.

Autor: Fábio O Pedrosa, Rose Adele Monteiro, Roseli Wassem, Leonardo M Cruz, Ricardo A Ayub, Nelson B Colauto, Maria Aparecida Fernandez, Maria Helena P Fungaro, Edmundo C Grisard, Mariangela Hungria, Humberto M F Madeira, Rubens O Nodari, Clarice A Osaku, Maria Luiza Petzl-Erler, Hernán Terenzi, Luiz G E Vieira, Maria Berenice R Steffens, Vinicius A Weiss, Luiz F P Pereira, Marina I M Almeida, Lysangela R Alves, Anelis Marin, Luiza Maria Araujo, Eduardo Balsanelli, Valter A Baura, Leda S Chubatsu, Helisson Faoro, Augusto Favetti, Geraldo Friedermann, Chirlei Glienke, Susan Karp, Vanessa Kava-Cordeiro, Roberto T Raittz, Humberto J O Ramos, Enilze Maria S F Ribeiro, Liu Un Rigo, Saul N Rocha, Stefan Schwab, Anilda G Silva, Eliel M Souza, Michelle Z Tadra-Sfeir, Rodrigo A Torres, Audrei N G Dabul, Maria Albertina M Soares, Luciano S Gasques, Ciela C T Gimenes, Juliana S Valle, Ricardo R Ciferri, Luiz C Correa, Norma K Murace, João A Pamphile, Eliana Valéria Patussi, Alberto J Prioli, Sonia Maria A Prioli, Carmem Lúcia M S C Rocha, Olívia Márcia N Arantes, Márcia Cristina Furlaneto, Leandro P Godoy, Carlos E C Oliveira, Daniele Satori, Laurival A Vilas-Boas, Maria Angélica E Watanabe, Bibiana Paula Dambros, Miguel P Guerra, Sandra Marisa Mathioni, Karine Louise Santos, Mario Steindel, Javier Vernal, Fernando G Barcellos, Rubens J Campo, Ligia Maria O Chueire, Marisa Fabiana Nicolás, Lilian Pereira-Ferrari, José L da Conceição Silva, Nereida M R Gioppo, Vladimir P Margarido, Maria Amélia Menck-Soares, Fabiana Gisele S Pinto, Rita de Cássia G Simão, Elizabete K Takahashi, Marshall G Yates, Emanuel M Souza

Publikováno v: PLoS Genetics, Vol 7, Iss 5, p e1002064 (2011)

The molecular mechanisms of plant recognition, colonization, and nutrient exchange between diazotrophic endophytes and plants are scarcely known. Herbaspirillum seropedicae is an endophytic bacterium capable of colonizing intercellular spaces of gras

Externí odkaz: https://doaj.org/article/309767e6e81d49009b81a2e9e05a4f2b